Development and validation of a dried blood spot—LC–APCI–MS assay for estimation of canrenone in paediatric samples

Dexamethasone quantification in dried blood spot samples using LC–MS: The potential for application to neonatal pharmacokinetic studies

“…The aim of this study was to determine whether DBS in principle, can be used for the measurement of relatively low circulating blood levels of dexamethasone in neonates administered the drug. The advantages of DBS based methods coupled with improved analytical capability has led to a recent rise in the use of this methodology in drug quantification studies; with application to fields including therapeutic drug monitoring [21,22,23], toxicology [24] and pharmacokinetics studies [25][26][27][28].…”

Potassium canrenoate treatment in paediatric patients

“…In addition, a whole blood sample was collected from full-term infants and children in EDTA tubes, at the time of each blood spot collection; the plasma fraction was stored at À208C until analysis. DBS and plasma concentrations of canrenone, the active metabolite of K-canrenoate, were also measured in matched samples from another group of 16 patients recruited in a previous study [10] using developed and validated bioanalytical methods [11,12]. Accurate data regarding time of sampling and timing of K-canrenoate doses were recorded for each sample.…”

Captopril Determination in Dried Blood Spot Samples with LC-MS and LCHRMS: A Potential Method for Neonate Pharmacokinetic Studies

“…The ease of sample storage and transmission between sites has led to a surge in the use of this methodology for various applications including therapeutic drug monitoring, toxicokinetic (TK) and pediatric pharmacokinetic (PK) studies [20][21][22][23][24][25][26][27][28][29][30][31]. High Resolution Mass Spectrometry (HRMS) offers an alternative route to the compound specificity provided by the MS/MS instrument [19].…”