Development and Validation of a Rapid RP HPLC Method for the Determination of Cinitapride Hydrogen Tartarate in Solid Oral Dosage Forms

Humaira, Syeda; Dey, Akalanka; Raju, S. Appala; Sanaullah, Syed

doi:10.1155/2011/614160

Cited by 6 publications

(7 citation statements)

References 2 publications

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“…The average percentages found for different concentrations were based on the average of three replicate determinations. The results shown in Table are in good agreement with those obtained using comparison methods . Statistical analysis of the results obtained using the Student's t ‐test and variance ratio F ‐test showed no significant difference between the performance of the two methods regarding accuracy and precision, respectively.…”

Section: Resultssupporting

confidence: 81%

“…Statistical analysis of the results obtained with the proposed and comparison methods using the Student's t ‐test and variance ratio F ‐test showed no significant differences between the two methods in regarding accuracy and precision (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…AMS has been the subject of monographs in the British Pharmacopoeia and the European Pharmacopoeia . Reviewing the literature revealed that only a few analytical methods have been reported for the determination of AMS including spectrophotometry , high‐performance liquid chromatography (HPLC) and liquid chromatography–mass spectrometry (LC‐MS) . Bumadizone calcium semi‐hydrate (BUM) is butylmalonic acid mono‐(1,2‐diphenylhydrazide) calcium semi‐hydrate; (Fig.…”

Section: Introductionmentioning

confidence: 99%

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Spectrofluorimetric determination of amisulpride and bumidazone in raw materials and tablets

et al. 2014

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A highly sensitive, simple and rapid spectrofluorimetric method was developed for the determination of amisulpride (AMS) and bumidazone (BUM) in tablet form. The proposed method is based on measuring the native fluorescence of the studied drugs in methanol at 360 and 344 nm after excitation at 276 and 232 nm for AMS and BUM, respectively. The fluorescence-concentration plots were rectilinear over the ranges of 5.0-60.0 ng/mL for AMS and 0.5-5.0 µg/mL for BUM. The lower detection limits were 0.70 ng/mL and 0.06 µg/mL, and the lower quantification limits were 2.0 ng/mL and 0.18 µg/mL for AMS and BUM, respectively. The method was successfully applied for the analysis of AMS and BUM in commercial tablets. Statistical evaluation and comparison of the data obtained using the proposed and comparison methods revealed good accuracy and precision for the proposed method.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Spectrofluorimetric determination of amisulpride and bumidazone in raw materials and tablets

et al. 2014

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“…All results obtained by the developed ECL method were evaluated by its comparison with results of one reported approach to give a strong indication about precision/accuracy of the developed ECL method. For this purpose, a spectrophotometric reported method was used as comparison method for AMS determination [8a] . Student's t‐test and variance ratio F‐test were employed for statistical analysis [14] of all data.…”

Section: Resultsmentioning

confidence: 99%

Amplified Electrochemiluminescence of the Luminol‐Amisulpride System and its Application for the Ultrasensitive Detection of Amisulpride

Halawa

Saqib

2023

ChemistrySelect

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Electrochemiluminescence (ECL) has emerged as a powerful tool in bioassays due to its unique versatility and controllability, but it is still a challenge to amplify ECL signals without utilizing complex synthetic processes, sophisticated nanomaterials, and catalysts. Herein, a new ECL system with high sensitivity and selectivity is reported for the detection of amisulpride (AMS). The AMS was beneficial for enhancing the weak ECL emission of luminol, wherein co‐reaction effect of AMS promoted the generation of superoxide anion radicals (O2⋅−), which significantly improved the ECL efficiency of luminol (emitter). Under the optimized experimental conditions, this anodic ECL system achieved AMS detection (a biphasic curve) with linear concentration ranges of 0.2–5.0 μm and 5.0–100.0 μm. Impressively, the developed system exhibited a low limit of detection (LOD) and quantification (LOQ) of 10.2 nm and 50.5 nm for AMS, respectively. This luminol‐based ECL system is further applied for sensitive AMS detection in real (bulk) drug and pharmaceutical tablet form. Moreover, statistical comparison between the developed and comparison method showed good precision and accuracy of the developed method.

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“…MEM produces its effect through the blockade of current through channels of N-methyl-D-aspartate receptors broadly involved in brain function, while PXL is a dopamine agonist recently approved for the early and advanced Parkinson's disease [2]. Different techniques are used for the determination of MEM, including HPLC [3][4][5][6][7][8][9][10][11][12][13][14][15], gas chromatography coupled to mass spectrometry (GC-MS) [16], capillary zone electrophoresis [17][18], potentiometry [19], polarography [20] and spectrophotometry [21,22], while PXL can be quantitatively estimated by HPLC [23][24][25][26][27][28][29], GC-MS [30], capillary zone electrophoresis [31] and spectrophotometric methods [32][33][34]. The aim of this work is to develop simple membrane sensors that can be used for the determination of MEM and PXL as a pure drug, in pharmaceutical dosage forms and in spiked human plasma.…”

Section: Introductionmentioning

confidence: 99%

Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate

Merey¹,

Helmy²,

Tawakkol³

et al. 2012

Port. Electrochim. Acta

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Five solid membrane sensors responsive to memantine hydrochloride (MEM) and pramipexole dihydrochloride monohydrate (PXL) are described for simple and fast determination of these drugs in pharmaceutical preparation and human plasma. The first and the second sensors are based on the formation of an ion association complex between MEM as a cationic drug with Na tetra phenyl borate and ammonium reineckate (as anionic exchanger), respectively. The third sensor is based on the formation of an ion association complex between PXL with ammonium reineckate. The produced electroactive material is dispersed in PVC matrix. While the other fourth and fifth sensors are based on using functionalized lipophilic cyclodextrin derivative (2-hydroxypropyl-β-cyclodextrin) as sensor ionophore for the determination of MEM and PXL. The performance characteristics of these sensors-evaluated according to IUPAC recommendations-reveal fast, stable and near Nernstian response for 1x10-4-1x10-1 M and 1x10-6-1x10-2 M for (MEM) and (PXL), respectively. Many inorganic and organic substances such as drug excipients and diluents normally used in drug formulations do not interfere with drugs response. Statistical comparison between the results obtained by applying the proposed potentiometric method for the determination of the (MEM) and (PXL) in their pure powder forms and those obtained by applying the reported methods was done and no significant difference was found at p = 0.05. Validation of the method according to ICH guidelines shows the suitability of the sensors for quality control analysis of the cited drugs in pharmaceutical formulations and human plasma. The proposed sensors can also be used as a detector for HPLC.

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Development and Validation of a Rapid RP HPLC Method for the Determination of Cinitapride Hydrogen Tartarate in Solid Oral Dosage Forms

Cited by 6 publications

References 2 publications

Spectrofluorimetric determination of amisulpride and bumidazone in raw materials and tablets

Spectrofluorimetric determination of amisulpride and bumidazone in raw materials and tablets

Amplified Electrochemiluminescence of the Luminol‐Amisulpride System and its Application for the Ultrasensitive Detection of Amisulpride

Potentiometric Membrane Sensors for Determination of Memantine Hydrochloride and Pramipexole Dihydrochloride Monohydrate

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