Development and validation of new diagnostic criteria for acute retinal necrosis

Takase, Hiroshi; Okada, Annabelle A.; Gotô, Hiroshi; Mizuki, Nobuhisa; Namba, Kenichi; Ohguro, Nobuyuki; Sonoda, Koh Hei; Tomita, Makoto; Keino, Hiroshi; Kezuka, Takeshi; Kubono, Reo; Mizuuchi, Kazuomi; Shibuya, Etsuko; Takahashi, Hiroyuki; Yanai, Ryoji; Mochizuki, Manabu

doi:10.1007/s10384-014-0362-0

Cited by 73 publications

(54 citation statements)

References 11 publications

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“…11–15 It has been proposed to include laboratory data in the diagnostic criteria for ARN. 16 Both qualitative and quantitative real-time PCR testing may be used both to ascertain the etiology of ARN and potentially to assess the response of ARN to therapy. 17,18 The differential diagnosis for ARN includes other infectious and inflammatory processes such as syphilis, toxoplasmosis, cytomegalovirus retinitis, Behcet’s disease, pars planitis, sarcoidosis, and intraocular lymphoma.…”

Section: Diagnosismentioning

confidence: 99%

Advances in the Management of Acute Retinal Necrosis

Shantha

Weissman

Debiec

et al. 2015

International Ophthalmology Clinics

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Acute retinal necrosis is a viral syndrome characterized by a panuveitis with necrotizing retinitis that may be complicated by retinal detachment, vaso-occlusion, optic neuropathy, and other causes of decreased visual acuity. Polymerase chain reaction testing provides a rapid and sensitive method of identifying the viral etiology of acute retinal necrosis, which is most commonly caused by herpes simplex virus type 1, herpes simplex virus type 2, and varicella zoster virus. Prompt diagnosis and treatment is paramount to prevent further vision loss. We review the management of acute retinal necrosis including systemic, local intravitreal, and combination antiviral medications. We also discuss the appropriate and inappropriate use of corticosteroids, laser retinopexy, surgical therapy, and other adjunctive measures.

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Section: Diagnosismentioning

confidence: 99%

Advances in the Management of Acute Retinal Necrosis

Shantha

Weissman

Debiec

et al. 2015

International Ophthalmology Clinics

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“…The study was first published (Epub) in December 2014. 13 Their criteria used a combination of clinical features consistent with ARN, including six early-stage ocular findings and five clinical courses. The results of virologic testing of intraocular fluids by means of PCR or GWC for herpes simplex virus (HSV) or varicella zoster virus (VZV) belonged to the five clinical courses.…”

Section: Discussionmentioning

confidence: 99%

Acute Retinal Necrosis: Diagnostic and Treatment Strategies in Germany

Winterhalter

Stuebiger

Maier

et al. 2015

Ocular Immunology and Inflammation

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“…The American Uveitis Society released its criteria for diagnosis of acute retinal necrosis syndrome in 1994 ( Table 1) [2]. Takase et al [3] described a newer diagnostic criteria which includes: six ocular findings in the early stage, five clinical courses, and the virologic tests of intraocular fluids. (1f) Associated elevated intraocular pressure (IOP).…”

Section: Acute Retinal Necrosismentioning

confidence: 99%

“…A "virus-confirmed ARN" was defined as the presence of ocular findings in stage 1a and 1b, the presence of any one of the five clinical courses, and a positive virologic test result. A "virus-unconfirmed ARN" was defined by them as the presence of four of six early stage ocular findings including 1a and 1b, presence of any two of the five clinical courses, a negative virologic test result, or when virologic testing had not been performed [3].…”

Section: Virologic Testingmentioning

confidence: 99%

Viral Retinitis: Diagnosis and Management Update

Dhami¹,

Malhi²

2019

Advances in the Diagnosis and Management of Uveitis

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Cytomegalovirus, herpes simplex, and herpes zoster are responsible for the majority of cases of viral retinitis and can occur in both healthy and immunocompromised or immunodeficient individuals. Herpes zoster has been strongly incriminated as a causal agent in acute retinal necrosis in immunocompetent patients. Epstein Barr virus has been described in various ocular inflammatory diseases including multifocal choroiditis in healthy patients. In immunocompromised or immunodeficient patients, various opportunistic viral infections can occur; the most common being cytomegalovirus (CMV) infection. Other less common viruses causing retinal infections include herpes simplex virus (HSV) and varicella zoster virus (VZV). The vision-threatening complications associated with infectious viral disease are disastrous in nature due to rapid progression. The inability to control this viral retinitis requires early detection by the clinician with prompt and aggressive initiation of the drug therapy to prevent complications.

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Development and validation of new diagnostic criteria for acute retinal necrosis

Abstract: New diagnostic criteria for ARN were developed and found to achieve high statistical values.

Cited by 73 publications

References 11 publications

Advances in the Management of Acute Retinal Necrosis

Advances in the Management of Acute Retinal Necrosis

Acute Retinal Necrosis: Diagnostic and Treatment Strategies in Germany

Viral Retinitis: Diagnosis and Management Update

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