Development and validation of novel LC–MS/MS method for determination of Lusutrombopag in rat plasma and its application to pharmacokinetic studies

Simultaneous measurement of free and conjugated estrogens in surface water using capillary liquid chromatography tandem mass spectrometry

“…Significant signals from interference should not be detected at the corresponding retention time of the chosen compounds. 49 As the presence of matrix effects causes instability of accuracy and reproducibility to the established method, in particular when the ESI source was applied for analysis. To determine matrix effects arising from the surface water, the slope of matrix matched calibration curve was divided by the slope derived from the neat standard calibration curve, which is expressed as:…”

Method development, validation, and application of liquid chromatography-electrospray ionization-mass spectrometry/mass spectrometry method for the quantification of amprenavir in plasma samples

“…The recoveries (extraction) were calculated by calculating six responses of the peak ratios of HQC, MQC, and LQC level solutions of amprenavir to spiked sample solutions after extraction at respective concentration levels (El-Zaher et al, 2019;Singh et al, 2020). In the same manner, extraction recoveries of rilpivirine were calculated by calculating the peak area ratios of quality control plasma sample solutions (n = 6) to spiked human plasma samples at respective concentration levels.…”

Monitoring of Aflatoxins B1, G1, B2, and G2 in Spices from Riyadh Markets by Liquid Chromatography Coupled to Tandem Mass Spectrometry

“…The use of appropriate analytical technology is an important step in addition to the extraction method itself. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) has key advantages, such as improved precision and accuracy, greater selectivity, high sensitivity, and speed [ 14 , 15 ]. Therefore, interest in this technology has been increasing recently, especially in determining AF levels in food [ 16 ].…”