Development and Validation of UV Spectrophotometric Method for The Simultaneous Estimation of Rosuvastatin and Ezetimibe in Pharmaceutical Dosage Form

Sireesha, D; Monika, M. Laksmi; Bakshi, Vasudha

doi:10.5958/2231-5675.2017.00021.7

Asian Jour. Pharmac. Anal.

2017

DOI: 10.5958/2231-5675.2017.00021.7

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Development and Validation of UV Spectrophotometric Method for The Simultaneous Estimation of Rosuvastatin and Ezetimibe in Pharmaceutical Dosage Form

D Sireesha¹,

M. Laksmi Monika²,

Vasudha Bakshi³

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Cited by 10 publications

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“…Literature survey found less methods to determine the clopidogrel, aspirin and some are reported for ezetimibe and rosuvastatin [11,12] only. Some authors [13][14][15] reported rosuvastatin and ezetimibe in pharmacokinetic studies. Main objective of this study was to develop a single HPLC method to determine aspirin, rosuvastatin, ezetimibe and clopidogrel in tablets dosage form.…”

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confidence: 99%

HPLC Method for Determination of Aspirin, Rosuvastatin, Ezetimibe and Clopidogrel in Combination Drug Products

Palacharla

Mohan

2019

Asian J. Chem.

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A single HPLC method for the determination of four active ingredients viz. aspirin, rosuvastatin, ezetimibe and clopidogrel in less run time is developed. HPLC method was developed and validated. X-terra C18 100 × 4.6 mm, 3.5 μ HPLC column, KH2PO4 buffer (mobile phase A) and acetonitrile (mobile phase B) were used. 20 μ injection volume, 1.0 mL/min flow rate, 230 nm and ambient column oven temperature were applied for separation. Gradient program: at 0 min mobile phase-B 13 %, at 4 min 13 %, at 8 min 44 %, 14 min 57 %, 17 min 57 %, 20 min 13 % and 25 min 13 %. Method validation was performed as per ICH guidance with precision, linearity, specificity, accuracy, ruggedness and robustness. Validation results were satisfactory and this method can be applied for regular drug product manufacturing

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mentioning

confidence: 99%

HPLC Method for Determination of Aspirin, Rosuvastatin, Ezetimibe and Clopidogrel in Combination Drug Products

Palacharla

Mohan

2019

Asian J. Chem.

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Stability-indicating RP-HPLC assay of three novel oral anticoagulants binary mixtures with rosuvastatin calcium: Application to pharmaceutical preparations and human plasma

Hamdy

Korany

Ebied

et al. 2022

Journal of Chromatography B

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Eco-friendly second derivative synchronous fluorescence spectroscopic method for simultaneous determination of rosuvastatin and ezetimibe in pharmaceutical capsules

Ramzy,

Althobaiti,

Almalki

2025

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Development and Validation of UV Spectrophotometric Method for The Simultaneous Estimation of Rosuvastatin and Ezetimibe in Pharmaceutical Dosage Form

Cited by 10 publications

References 0 publications

HPLC Method for Determination of Aspirin, Rosuvastatin, Ezetimibe and Clopidogrel in Combination Drug Products

HPLC Method for Determination of Aspirin, Rosuvastatin, Ezetimibe and Clopidogrel in Combination Drug Products

Stability-indicating RP-HPLC assay of three novel oral anticoagulants binary mixtures with rosuvastatin calcium: Application to pharmaceutical preparations and human plasma

Eco-friendly second derivative synchronous fluorescence spectroscopic method for simultaneous determination of rosuvastatin and ezetimibe in pharmaceutical capsules

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