Development, characterization &amp; in vitro skin permeation of rutin ethosomes as a novel vesicular carrier

Dhiman, Anju; Singh, Deepika

doi:10.7439/ijbr.v4i10.398

Cited by 6 publications

(4 citation statements)

References 13 publications

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“…Based on the physicochemical properties of the drug(s), it may be dissolved either in an aqueous or inorganic phase [83]. The organic phase is added drop by drop to the aqueous medium with continuous stirring to obtain the vesicles [84].…”

Section: Methods Of Preparationmentioning

confidence: 99%

“…In the hot process, phospholipids dispersed in purified water are added to the organic phase containing ethanol, cholesterol, and an edge activator or permeation enhancer (deformable vesicles) at 40 °C. The vesicular size is reduced by sonication or the high-pressure extrusion method [84,85]. In the ethanol injection method, drops of ethanol are added to the aqueous phase with constant stirring.…”

Section: Methods Of Preparationmentioning

confidence: 99%

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Lipid-Based Vesicles: a Non-invasive Tool for Transdermal Drug Delivery

Raj

Vadakkepushpakath

et al. 2021

J Pharm Innov

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The emergence of lipid nanovesicles (LNVs), like liposomes, transferosomes, and ethosomes, strengthens transdermal drug delivery. The composition of lipid vesicles is similar to that of skin, so these can easily penetrate through the skin. Modifications in the design of lipid vesicles help enhance skin permeation; therefore, dose reduction is possible. Ultradeformable vesicles are superior to conventional lipid vesicles because of their better stability. Various methods used to prepare LNVs are the classical cold method, ethanol injection method, ether injection method, and film hydration method. The method of preparation is crucial because it drastically affects the characteristics of vesicles. The vesicles are evaluated for their physicochemical and biological properties. Since vesicular systems are more susceptible to physical, chemical, and biological degradation, their stability is critical and challenging. The transdermal applications of LNVs spread across all areas like antifungal, anti-inflammatory, and anticancer drugs and the delivery of proteins and peptides.

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Section: Methods Of Preparationmentioning

confidence: 99%

Section: Methods Of Preparationmentioning

confidence: 99%

Lipid-Based Vesicles: a Non-invasive Tool for Transdermal Drug Delivery

Raj

Vadakkepushpakath

et al. 2021

J Pharm Innov

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“…Rutin, in its free state, is unstable when exposed to UV rays and cannot permeate through the stratum corneum (Bakowska et al 2003). A growing body of research has confirmed better photostability and permeability of rutin in nanosystem forms (e.g., nanoparticle, nanoemulsion, liposome-in-hydrogel) (Das and Kalita 2014;Dhiman and Singh 2015;Park et al 2014) compared with free rutin. Attempting to improve its photostability profile and antioxidant effects, Oliveira et al strategically formulated rutin nanoparticles with SPF enhancing property.…”

Section: Flavonolmentioning

confidence: 99%

Current developments in the nanomediated delivery of photoprotective phytochemicals

Kumar

Jose

2020

Environ Sci Pollut Res

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Natural products have been used to protect the skin from harmful UV radiation for decades. Due to the ecotoxicological implications of synthetic sunscreen exposure in aquatic ecosystems, there is a greater need to explore alternative sources of UV filters. Recent research has focused on discovering novel UV absorbing photoprotective molecules from nature. In response to the excessive damage caused by UVB rays, plants induce the production of high concentrations of phytoprotective secondary metabolites and anti-oxidative enzymes. Despite promising UV absorbing and photoprotective properties, plant secondary metabolites have been underutilized in topical delivery due to low solubility and high instability. Numerous phytochemicals have been effectively nanosized, incorporated in formulations, and studied for their sustained effects in photoprotection. The present review outlines recent developments in nanosizing and delivering photoprotective crude plant extract and phytochemicals from a phytochemical perspective. We searched for articles using keywords: "UV damage," "skin photoprotection," "photodamage," and "nano delivery" in varied combinations. We identified and reviewed literature from 43 original research articles exploring nanosized phytochemicals and crude plant extracts with photoprotective activity. Nanosized phytochemicals retained higher amounts of bioactive compounds in the skin and acted as depots for their sustained release. Novel approaches in nanosizing considerably improved the photostability, efficacy, and water resistance of plant secondary metabolites. We further discuss the need for broad-spectrum sunscreen products, potential challenges, and future growth in this area.

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“…For the studies at 25 C ± 2 C/60 ± 5% RH and 40 C ± 2 C/70 ± 5% RH, patches were stored in a stability chamber (Model NEC2355; Nutronics India, New Delhi, India). Sampling was done on 0, 15, 30, 45, 60, 90, 120 and 180 days [45,46]. Drug content (%) was evaluated at the end of the specified period [47].…”

Section: Stability Studymentioning

confidence: 99%

Rutin–phospholipid complex in polymer matrix for long-term delivery of rutin via skin for the treatment of inflammatory diseases

Kalita

Das

2017

Artificial Cells, Nanomedicine, and Biotechnology

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The drug with poor oral bioavailability necessitates the development of novel carrier for efficient drug delivery. This paper reports the rutin-phospholipid complex in polymer matrix for sustained delivery of rutin via the skin for the treatment of acute and chronic inflammatory diseases. Rutin in phospholipid complex (RNPs) are better soluble and permeable than the free rutin. The RNPs-loaded polymeric matrix patch with moderate adhesiveness was developed for convenient means of long term drug application on the skin. The patch was analysed for physicochemical properties, ex vivo skin permeability and in vivo efficacy in rat paw oedema model. The skin targeting efficacy was analysed by CLSM study. Optimized formulation (F2) showed 31 ± 2.32% and 26.56 ± 5.52% skin permeation at 24 h across excised rat skin and human cadaver skin, respectively. The sustained anti-inflammatory effect of the patch formulation in rat paw oedema model confirmed its unique in vivo efficacy over the conventional diclofenac gel. The CLSM study confirmed the localization of RNPs in the dermis for sustained anti-inflammatory effect. Our results suggest that the developed patch has a potential for long term site specific delivery of rutin in arthritic patients.

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Development, characterization & in vitro skin permeation of rutin ethosomes as a novel vesicular carrier

Cited by 6 publications

References 13 publications

Lipid-Based Vesicles: a Non-invasive Tool for Transdermal Drug Delivery

Lipid-Based Vesicles: a Non-invasive Tool for Transdermal Drug Delivery

Current developments in the nanomediated delivery of photoprotective phytochemicals

Rutin–phospholipid complex in polymer matrix for long-term delivery of rutin via skin for the treatment of inflammatory diseases

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