Development of a Hybrid Dextrin Hydrogel Encapsulating Dextrin Nanogel As Protein Delivery System

Molinos, Maria; Carvalho, Vera; Silva, Dina M.; Gama, Miguel

doi:10.1021/bm2015834

Cited by 85 publications

(85 citation statements)

References 52 publications

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“…Cytotoxicity, is defined as the "in vitro evaluation of toxicological risks of a material using cell culture". 46 Cytotoxicity assay is used to investigate in vitro biocompatibility of materials intended to be used for drug delivery application. This is a useful tool to scrutinize a material for in vivo application.…”

Section: Resultsmentioning

confidence: 99%

Biocompatible and Mucoadhesive Bacterial Cellulose-g-Poly(acrylic acid) Hydrogels for Oral Protein Delivery

et al. 2014

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Stimuli-responsive bacterial cellulose-g-poly(acrylic acid) hydrogels were investigated for their potential use as an oral delivery system for proteins. These hydrogels were synthesized using electron beam irradiation without any cross-linking agents, thereby eliminating any potential toxic effects associated with cross-linkers. Bovine serum albumin (BSA), a model protein drug, was loaded into the hydrogels, and the release profile in simulated gastrointestinal fluids was investigated. Cumulative release of less than 10% in simulated gastric fluid (SGF) demonstrated the potential of these hydrogels to protect BSA from the acidic environment of the stomach. Subsequent conformational stability analyses of released BSA by SDS-PAGE, circular dichroism, and an esterase activity assay indicated that the structural integrity and bioactivity of BSA was maintained and preserved by the hydrogels. Furthermore, an increase in BSA penetration across intestinal mucosa tissue was observed in an ex vivo penetration experiment. Our fabricated hydrogels exhibited excellent cytocompatibility and showed no sign of toxicity, indicating the safety of these hydrogels for in vivo applications.

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Section: Resultsmentioning

confidence: 99%

Biocompatible and Mucoadhesive Bacterial Cellulose-g-Poly(acrylic acid) Hydrogels for Oral Protein Delivery

et al. 2014

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“…Previous studies have shown that nanogel-embedded hydrogel composites could improve the kinetic release profi le of the drug by affording a nanoscale reservoir barrier, which reduced or even removed the burstrelease effects of drugs in hydrogel or nanogel drug-delivery systems. [ 38,39 ] We envisioned that incorporating periodateoxidized cholesterol-containing dextran (OCDEX) nanogels as drug carriers in a hydrogel would improve the formulation and make it more suitable for drug delivery. As a chemical crosslinker, the aldehyde group-bearing OCDEX nanogel should react with the amino-bearing polysaccharide/polypeptide 4. c) Drug-loaded hydrogels were formulated by the ionic crosslinking of negatively charged PPLG with positively charged polysaccharide/ polypeptide composites (HPCS/PPLL) and the simultaneous Schiff-base reaction between amino-containing HPCS/PPLL complexes and aldehyde group-bearing nanogels containing IL-2, IFN-γ and DOX.…”

Section: Introductionmentioning

confidence: 99%

Nanogel‐Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo–Protein Combination Therapy

et al. 2015

Adv Funct Materials

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Chemo-and protein-based therapeutics are two major modalities for the treatment of malignant tumors with drastically different therapeutic indices, toxicity, and other pharmacological properties. For intended in vivo applications, they also have distinctly different formulation challenges to be addressed separately. In this study, we attempt to overcome the formulation barriers of chemo-and protein-based therapeutics, and report the development of injectable nanogels, a class of crosslinked physical and chemical composite gels (

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“…[1] Molinos, M, Carvalho V, et al, 2012. Development of a hybrid dextrin hydrogel encapsulating dextrin nanogel as protein delivery system.…”

Section: Referencesmentioning

confidence: 99%

Book of Abstracts of Ceb Annual Meeting 2017

Ferreira¹

2017

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ForewordThe Centre of Biological Engineering (CEB, from the Portuguese title 'Centro de Engenharia Biológica') is a research unit of the School of Engineering of the University of Minho, which is recognized as a strategic infrastructure for the development of the Portuguese Biotechnology and Bioengineering fields. The mission of CEB is to generate, disseminate, and apply knowledge with relevance for society in the economic, social and cultural dimensions, and to contribute to the expansion of the scientific and technological fields under its scope of activity. The research carried out at CEB covers the molecular, cellular and process scales, combining knowledge from the exact, natural, health, environmental and engineering sciences, in order to develop new products and processes as well as a wide range of bioengineering and biotechnological applications in the agro-food, environmental, energy, industrial fine chemistry, biomedical and health fields. CEB combines R&D activities with advanced training, technology transfer, consulting and services, with the aim of fostering the industrial and agro-food, health, and environmental sectors.The CEB's activities developed within three main thematic lines (industrial/Food; Environment; Health) follow closely the guidelines defined by the European Commission concerning the establishment of the Knowledge-Based Bio-Economy concept and are in agreement with the targets defined by the EU HORIZON 2020 program and the research and innovation strategies for smart specialisation (RIS3) defined by the Portugal North region. CEB has a strategic and ambitious research plan to respond to the new the challenges, which have resulted from the extraordinary developments and breakthroughs in subjects like Molecular Biotechnology, Systems and Synthetic Biology, and Nanotechnology. All these cutting-edge and fast growing/moving topics clearly demand for a mid/long term investment in both research infrastructures and human resources. CEB's contribution to these efforts relies on the integration of different scientific and technological subjects and competences of excellence, through the complementarities and synergies of its seven research groups. All this is confirmed by the excellent records of accomplishment of its members, namely international scientific articles and respective citations, publication of books, PhD theses, and the volume of funding obtained in competitive national and European programs, editorial memberships of international journals and technical committees, the organization of international conferences, industry-led projects, patents, the creation of spin-offs, etc. Working as a research network in Portugal with strong international connections, CEB also plays a key role in the deployment of advanced doctoral programmes with close links to highly reputed institutions, such as MIT, aiming at contributing to the establishment of new start-up companies in the area of Biotechnology and Bioengineering.This one-day meeting is intended to bring together all CEB researchers fro...

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Development of a Hybrid Dextrin Hydrogel Encapsulating Dextrin Nanogel As Protein Delivery System

Cited by 85 publications

References 52 publications

Biocompatible and Mucoadhesive Bacterial Cellulose-g-Poly(acrylic acid) Hydrogels for Oral Protein Delivery

Biocompatible and Mucoadhesive Bacterial Cellulose-g-Poly(acrylic acid) Hydrogels for Oral Protein Delivery

Nanogel‐Incorporated Physical and Chemical Hybrid Gels for Highly Effective Chemo–Protein Combination Therapy

Book of Abstracts of Ceb Annual Meeting 2017

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