To test and evaluate performance, fuel efficiency and emission of fuel cell hybrid vehicles, a laboratory equipped with a heavy duty chassis dynamometer is constructed by CATARC collaborates with Tsinghua University. The framework of the chassis dynamometer laboratory is designed. Then, three hydrogen consumption measurement methods are researched, and a hydrogen energy consumption measurement system for the laboratory is developed. Finally, the application of the chassis dynamometer laboratory is presented, especially several tests for the accuracy and the reliability of the hydrogen energy consumption measurement system is carried out. Certification tests and researches for both heavy duty and light duty fuel cell hybrid vehicles can be carried out in this chassis dynamometer laboratory.