Development of a low power miniature linear ion trap mass spectrometer with extended mass range

Li, Gang; Cheng, Yongjun; Peng, Xiaoqiang; Zhang, Huzhong; Wang, Yongjun; Sun, Jian; Dong, Meng

doi:10.1063/1.4993506

Cited by 10 publications

(12 citation statements)

References 40 publications

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“…17,21 Mass analyzers have also been miniaturized, which could help in terms of reducing the requirements of the electronic system, as well as increasing its tolerance to higher buffer gas pressures. 22−25 Ionization is the first step in mass spectrometry; the voltage applied is used to convert neutrals into gas-phase ions for mass analysis. 26−28 Conventional direct current (DC) high-voltage power creates ion sources suffering from inherent disadvantages, such as high cost, limited portability and safety concerns.…”

Section: Introductionmentioning

confidence: 99%

Improving the Performance of the Mini 2000 Mass Spectrometer with a Triboelectric Nanogenerator Electrospray Ionization Source

et al. 2018

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Balancing the contradiction between portability and analytical performances of a miniaturized mass spectrometer is vital to extend its on-site applications. In this study, triboelectric nanogenerator (TENG)-driven ion sources were coupled with our home-built Mini 2000 system and applied to the analyses of different samples. Compared with the conventional direct current (DC) nanoelectrospray ionization (nanoESI) source, the ion intensity of the TENG-nanoESI miniature mass spectrometer was improved by ∼3 times. Moreover, maybe due to the different pathways of ion formation in comparison with DC electrospray, TENG electrospray is shown to reduce the salt suppression effect during ionization. With these figures of merit, the direct detection of reserpine in saliva was demonstrated using the TENG-Mini 2000 system.

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Section: Introductionmentioning

confidence: 99%

Improving the Performance of the Mini 2000 Mass Spectrometer with a Triboelectric Nanogenerator Electrospray Ionization Source

et al. 2018

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“…The schematic structure of the experimental system. 17 LIT: linear ion trap. where V is the volume of the sample (assuming the ions are uniformly distributed in space); p i is the ionization probability of a molecule; n is proportional to the signal intensity before the ion number reaching saturation, so it is reasonable to examine sensitivity by discussing the relation between the intensity and the ionization time.…”

Section: Methodsmentioning

confidence: 99%

“…The geometry of the LIT with hyperbolic electrodes has been listed in our previous works, which is designed with an inscribed circle radius of 4 mm and a length of 40 mm. 17 The surfaces of the electrodes are hyperbolic, so the electric fields E quad , E ac , and E dc inside the LIT cannot be uniform. A numerical method has been developed based on boundary element method to calculate charge distribution on electrode surfaces.…”

Section: Theoretical Analysismentioning

confidence: 99%

“…The geometry of the LIT with hyperbolic electrodes has been listed in our previous works, which is designed with an inscribed circle radius of 4 mm and a length of 40 mm. 17

Figure 1.The configuration of the LIT electrodes. (a) Radial view of the electrodes 1 and 3 are front and rear end caps, 2 are the hyperbolic electrodes and (b) axial view of signals applied on the hyperbolic electrodes, only RF signal is applied on the electrodes in y-direction, while RF signal, AC signal, and DC signal are applied on the electrodes in x-direction.…”

Section: Theoretical Analysismentioning

confidence: 99%

“…Previously, a miniature LIT mass spectrometer has been developed in our lab, the mass range of which could exceed 2000 Da with a reduced energy consumption under the auxiliary AC frequency scanning mode. 16,17 However, the performance of this miniature apparatus, especially the sensitivity, is degenerated due to limited size and energy consumption. Efforts have been made to improve the sensitivity of ion trap mass spectrometers.…”

Section: Introductionmentioning

confidence: 99%

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Improving the sensitivity of miniature linear ion trap mass spectrometer by a DC voltage applied on the eject electrodes

Li¹,

Cheng²,

Sun³

et al. 2018

Eur J Mass Spectrom (Chichester)

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A miniaturized linear ion trap mass spectrometer with continuous atmospheric pressure interface has been built in our lab. Significant extension in mass range and reduction in power consumption have been realized by the supplemental alternating current frequency scan mode. However, relatively poor sensitivity has been witnessed, which is directly dominated by the detection efficiency of the ion detector. Theoretical analysis has been implemented to find ways to improve the detection efficiency. The results show that enhanced sensitivity can be obtained by applying a direct current voltage on the pair of electrodes in eject direction. Experiments show that the sensitivity has been improved by more than one time due to the application of direct current voltage. With this design, this homemade miniature linear ion trap mass spectrometer can be used to analyze more rarefied samples, especially to on-site chemical analysis and space application.

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Experimental Observation of the Effects of Translational and Rotational Electrode Misalignment on a Planar Linear Ion Trap Mass Spectrometer

Tian

Decker

McClellan

et al. 2018

J. Am. Soc. Mass Spectrom.

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The performance of miniaturized ion trap mass analyzers is limited, in part, by the accuracy with which electrodes can be fabricated and positioned relative to each other. Alignment of plates in a two-plate planar LIT is ideal to characterize misalignment effects, as it represents the simplest possible case, having only six degrees of freedom (DOF) (three translational and three rotational). High-precision motorized actuators were used to vary the alignment between the two ion trap plates in five DOFs-x, y, z, pitch, and yaw. A comparison between the experiment and previous simulations shows reasonable agreement. Pitch, or the degree to which the plates are parallel along the axial direction, has the largest and sharpest impact to resolving power, with resolving power dropping noticeably with pitch misalignment of a fraction of a degree. Lateral displacement (x) and yaw (rotation of one plate, but plates remain parallel) both have a strong impact on ion ejection efficiency, but little effect on resolving power. The effects of plate spacing (y-displacement) on both resolving power and ion ejection efficiency are attributable to higher-order terms in the trapping field. Varying the DC (axial) trapping potential can elucidate the effects where more misalignments in more than one DOF affect performance. Implications of these results for miniaturized ion traps are discussed. Graphical Abstract ᅟ.

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Development of a low power miniature linear ion trap mass spectrometer with extended mass range

Cited by 10 publications

References 40 publications

Improving the Performance of the Mini 2000 Mass Spectrometer with a Triboelectric Nanogenerator Electrospray Ionization Source

Improving the Performance of the Mini 2000 Mass Spectrometer with a Triboelectric Nanogenerator Electrospray Ionization Source

Improving the sensitivity of miniature linear ion trap mass spectrometer by a DC voltage applied on the eject electrodes

Experimental Observation of the Effects of Translational and Rotational Electrode Misalignment on a Planar Linear Ion Trap Mass Spectrometer

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