Development of a microwave-assisted extraction of atropine and scopolamine from Solanaceae family plants followed by a QuEChERS cleanup procedure

Alkaloids of the Genus Datura: Review of a Rich Resource for Natural Product Discovery

“…More common is the application of the basic extract to solid-phase extraction columns, where the alkaloids are then eluted with dichloromethane or a similar solvent, as described by Berkov and colleagues (see below). In a recent report, Ciechomska [ 46 ] and colleagues developed a highly replicable, microwave-assisted extraction followed by solid-phase extraction to isolate atropine and scopolamine from D. metel , a technique which the authors report to consume less sample and less time than solid-liquid or Soxhlet extraction. It is worth noting that all published extraction methods should be approached critically.…”

Interpol review of controlled substances 2016–2019

“…Solanaceae : 2016 microwave-assisted extraction of atropine and scopolamine from Solanaceae family plants ( Datura and Brugmansia genera ) followed by QuEChERS SPE and GC-MS [ 856 ]; H-1 NMR-based metabolite profiling and quantification via HPLC-MS with focus on the tropane alkaloids were applied to compare leaf and root extracts of three wild types and two hybrids of Duboisia myoporoides and D. leichhardtii [ 857 ]; 2017 determination of tropane alkaloids (tropane alkaloids as atropine, scopolamine, anisodamine, tropane, tropine, littorine, homatropine, apoatropine, aposcopolamine, scopoline, tropinone, physoperuvine, pseudotropine and cuscohygrine) in cereals and solanaceaes seeds by LC coupled to single stage Exactive-Orbitrap [ 858 ]; 2018 simultaneous quantification of atropine and scopolamine in herbal tea and Solanaceae plant material by MALDI-TOF-MS/MS [ 859 ]; i dentification of 18 tropane alkaloids, 8 phenolic acids and related compounds and 7 flavonoids in extracts of L. pubiflora (of the Solanaceae family) by UHPLC-PDA-MS [ 860 ]; 2019 Scanning Electron Microscopy (SEM) and Light Microscopy (LM) 10 genera and 23 species of the Solanaceae family (Atropa acuminata, Capsicum decoraticus, Capsicum frutescens, Cestrum aurantiacum, Cestrum diurnum, Cestrum nocturnum, Datura alba, Datura innoxia, Datura stramonium, Hyoscymus niger, Lycopersicon esculentum, Nicotiana rustica, Nicotiana tabacum, Petunia alba, Petunia hybrida, Solanum erianthum, Solanum melongena, Solanum miniatum, Solanum pseudocapsicum, Solanum surratense, Solanum tuberosum, Withania coagulans, Withania somnifera) [ 861 ].…”

Soybean (Glycine max L.) isoflavones: Chemical composition and its chemometrics-assisted extraction and authentication

“…A modern approach to the optimization process was commonly conducted by employing a computational experimental design (Kleijnen, 2010). In natural product chemistry, experimental designs can be applied in analytical method development , biological product enhancement (Farombi et al, 2018;Managamuri et al, 2017;Momen et al, 2016;Srivastava et al, 2018;Talluri et al, 2019), and parameters selection for efficiency and economic consideration in biochemical processing (Ciechomska et al, 2016;Ha et al, 2018;Merib et al, 2014;Xiong et al, 2016).…”