Development of a nanotechnology-based approach for capturing and detecting nucleic acids by using flow cytometry

A comprehensive review of Dynamic Chemical Labelling on Luminex xMAP technology: a journey towards Drug-Induced Liver Injury testing

“…2). [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] Over the years, the DCL method has been combined with various bead-based platforms to analyze the expression of circulating miRs in biological uids (Table 1).…”

Improvement of Sensitivity and Speed of Virus Sensing Technologies Using nm- and μm-Scale Components

“…With the help of enrichment technology, e.g., bead-based enrichment [ 88 , 89 ], enrichment by specially designed probes [ 90 ], and droplets-encapsulating technology [ 91 ], the analysis of species of virus has become feasible. A virus can be captured, trapped, and lysed, and the nucleic acid can be amplified and detected, which has expanded the potential application of flow virometry.…”

Open a new window in the world of circulating microRNAs by merging ChemiRNA Tech with a Luminex platform

“…This technology uses the power of the Watson-Crick base pairing rules (C-G/A-T) that enable the dynamic covalent chemical reaction between the aldehyde group of the SMART Bases and the secondary amine on the abasic position of the DGL-Probe. 25,[27][28][29][30][31][32][33][34][35][36][37][38][39] In our previous studies, ChemiRNA Tech has been combined with some of the most advanced ultra-sensitive immunoassay platforms (such as Merck SMCxPro, Quanterix SIMOA and Luminex xMAP technology) to develop the socalled LiverAce™, the first platform-agnostic and PCR-free molecular assay for the direct detection and quantification of miR-122-5p, a biomarker for hepatotoxicity and Drug-Induced Liver Injury (DILI) diagnostics. 25,[38][39][40] However, and as also stated above, multiplex detection of miRs remains a major challenge in the use of miR signatures.…”

“…This technology uses the power of the Watson–Crick base pairing rules (C-G/A-T) that enable the dynamic covalent chemical reaction between the aldehyde group of the SMART Bases and the secondary amine on the abasic position of the DGL-Probe. 25,27–39…”