Development of a novel approach towards predicting the milling behaviour of pharmaceutical powders

Kwan, C.C.; Chen, Yong Qi; Ding, Yulong; Papadopoulos, Dimitris; Bentham, A.C.; Ghadiri, Mojtaba

doi:10.1016/j.ejps.2004.08.006

Cited by 50 publications

(19 citation statements)

References 18 publications

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“…Milling is one the most common particle size reduction step. The effect of milling parameters, such as milling frequency, impact velocity, milling time on particle bulk and surface properties, is well documented in the literature Adrjanowicz et al, 2011;Forcino et al, 2010;Vegt et al, 2009;Shariare et al, 2011;Perkins et al, 2009;Kwan et al, 2004;Kwan et al, 2003;Leleux and Williams, 2014;Newman and Zografi, 2014). Kwan et al investigated the effect of milling frequency and propensity of breakage for microcrystalline cellulose and α-lactose monohydrate.…”

Section: Introductionmentioning

confidence: 98%

Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders

Shah

Wang

Olusanmi

et al. 2015

International Journal of Pharmaceutics

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Particle bulk and surface properties are influenced by the powder processing routes. This study demonstrates the effect of milling temperatures on the particle surface properties, particularly surface energy and surface area, and ultimately on powder cohesion. An active pharmaceutical ingredient (API) of industrial relevance (brivanib alaninate, BA) was used to demonstrate the effect of two different, but most commonly used milling temperatures (cryogenic vs. ambient). The surface energy of powders milled at both cryogenic and room temperatures increased with increasing milling cycles. The increase in surface energy could be related to the generation of surface amorphous regions. Cohesion for both cryogenic and room temperature milled powders was measured and found to increase with increasing milling cycles. For cryogenic milling, BA had a surface area ∼ 5× higher than the one obtained at room temperature. This was due to the brittle nature of this compound at cryogenic temperature. By decoupling average contributions of surface area and surface energy on cohesion by salinization post-milling, the average contribution of surface energy on cohesion for powders milled at room temperature was 83% and 55% at cryogenic temperature.

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Section: Introductionmentioning

confidence: 98%

Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders

Shah

Wang

Olusanmi

et al. 2015

International Journal of Pharmaceutics

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“…Tests evaluating the mechanical properties on compacts include bending (three-and four-point), microindentation and compression tests (3)(4)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29). The main characteristics of mechanical characterization on compacts are the following: the materials have already been deformed during sample preparation; a large amount of materials is needed for formation of compacts; mechanical properties of particle assembly are determined (30)(31)(32)(33)(34).…”

Section: How Can Mechanical Particles Be Determined In Practice?mentioning

confidence: 99%

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

2016

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Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients # Nanoindentation allows quantitative determination of a material's response to stress such as elastic and plastic deformation or fracture tendency. Key instruments that have enabled great advances in nanomechanical studies are the instrumented nanoindenter and atomic force microscopy. The versatility of these instruments lies in their capability to measure local mechanical response, in very small volumes and depths, while monitoring time, displacement and force with high accuracy and precision. This review highlights the application of nanoindentation for mechanical characterization of pharmaceutical materials in the preformulation phase (primary investigation of crystalline active ingredients and excipients). With nanoindentation, mechanical response can be assessed with respect to crystal structure. The technique is valuable for mechanical screening of a material at an early development phase in order to predict and better control the processes in which a material is exposed to stress such as milling and compression.

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“…Such observations are in agreement with previous investigations. [23][24][25] In general, a decrease in median diameter from 115 AE 1 mm for the untreated lactose monohydrate to 63 AE 1 and 65 AE 1 mm for freshly milled and recrystallized lactose monohydrate samples was observed, respectively. It interesting to note however, that incremental increases in mill time resulted in an Figure 1.…”

Section: Results and Discussion Particle Sizing Of Processed Lactose mentioning

confidence: 89%

The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance

Young

Chan

Chiou

et al. 2007

Journal of Pharmaceutical Sciences

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Development of a novel approach towards predicting the milling behaviour of pharmaceutical powders

Cited by 50 publications

References 18 publications

Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders

Effect of milling temperatures on surface area, surface energy and cohesion of pharmaceutical powders

Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

The Influence of Mechanical Processing of Dry Powder Inhaler Carriers on Drug Aerosolization Performance

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