Development of a novel ‘nanocarrier’ system based on Halloysite Nanotubes to overcome the complexation of ciprofloxacin with iron: An in vitro approach

Rawtani, Deepak; Pandey, Gaurav; Tharmavaram, Maithri; Pathak, Pooja; Satyaprasad, A.; Agrawal, Y. K.

doi:10.1016/j.clay.2017.10.002

Cited by 87 publications

(38 citation statements)

References 72 publications

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“…The samples were dispersed in n-propanol for 5 min through ultrasonication. During sonication, a small droplet of the solution was taken and placed gently over a carbon coated copper grid [27]. The grid was settled for 5 min and used for TEM examination.…”

Section: Characterization Of Inorganic Fillersmentioning

confidence: 99%

“…HNTs were seen as cylindrical tubes with a transparent central area. The outer diameter of the nanotubes increases marginally after surface functionalization with APTES signifying coating of the nanotubes with amine groups [20,27]. The morphology of HNT/Ag demonstrated that the cylindrical shaped nanotubes were immobilized with spherical AgNPs, having particle size of 10-15 nm.…”

Section: Morphological Evaluationmentioning

confidence: 99%

“…The crystals structures of HNT, fHNT, HNT/Ag and AgNPs were characterized by XRD. The results showed that HNT exhibits diffraction peaks at 2ϴ values of 11.9 , 19.9 and 24.91 , which correspond to the (001), (020/110) and (002) basal plane present in its crystalline structure [27,38]. The results of fHNT demonstrated its characteristic peaks at 11.9 , 19.9 and 24.91 in 2ϴ, however lack of any new peak in the XRD pattern of fHNT shows the modification by APTES does not affect the structure of HNTs.…”

Section: X-ray Diffraction Of Hnt Fhnt Hnt/ag and Agnpsmentioning

confidence: 99%

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Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications

Barot

Rawtani

Kulkarni

2020

Heliyon

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The purpose of this study was to investigate the effect of Silver nanoparticle immobilized Halloysite Nanotubes (HNT/Ag) fillers on physicochemical, mechanical, and biological properties of novel experimental dental resin composite in order to compare with the properties of corresponding composites containing conventional glass fillers. Methods: Dental resin (Bis-GMA/TEGDMA with ratio 70/30) composites were prepared by incorporation of varied mass fraction of HNT/Ag. Experimental composites were divided into six groups, one control group and five experimental groups containing mass fraction 1 to 10.0 wt. % of HNT/Ag. Mechanical properties of the dental composites were recorded. Degree of conversion and depth of cure of the dental resin composites were assessed. Antimicrobial properties were assessed using agar diffusion test and evaluation of cytotoxicity were performed on NIH-3T3 cell line. Results: The inclusion of mass fractions (1-5 wt. %) of the HNT/Ag in dental resins composites, significantly improved mechanical properties. While, addition of larger mass fractions (7.5 and 10 wt. %) of the HNT/Ag did not show further improvement in the mechanical properties of dental resins composites. Theses composites also demonstrated satisfactory depth of cure and degree of conversion. A significant antibacterial activity was observed on S. mutans. No significant cytotoxicity was found on NIH-3T3 cell lines. Conclusion: The incorporation of HNT/Ag in Bis-GMA/TEGDMA dental resins composites resulted in enhancement in mechanical as well as biological properties for dental applications. Clinical significance: HNT/Ag containing dental composite is proposed to be highly valuable in the development of restorative dental material for patients with high risk of dental caries.

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Section: Characterization Of Inorganic Fillersmentioning

confidence: 99%

Section: Morphological Evaluationmentioning

confidence: 99%

Section: X-ray Diffraction Of Hnt Fhnt Hnt/ag and Agnpsmentioning

confidence: 99%

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Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications

Barot

Rawtani

Kulkarni

2020

Heliyon

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“…The structure and morphology of HNTs are dependent on the pore properties of nanotubes, also, it’s size could be easily changed under thermal, acidic and alkaline treatments 13 . The nano-sized tubular structure, mesoporosity and macroporosity of HNTs have been applied in several areas such as environmental uses 14 , tissue engineering 15 , cosmetic 16 , medicine 17 and catalysis 18 . HNTs with two kinds of hydroxyl groups in the inside and outside walls can be modified by different functional groups.…”

Section: Introductionmentioning

confidence: 99%

Mesoporous halloysite nanotubes modified by CuFe2O4 spinel ferrite nanoparticles and study of its application as a novel and efficient heterogeneous catalyst in the synthesis of pyrazolopyridine derivatives

Maleki

Hajizadeh

Salehi

2019

Sci Rep

105

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In this study, mesoporous halloysite nanotubes (HNTs) were modified by CuFe 2 O 4 nanoparticles for the first time. The morphology, porosity and chemistry of the CuFe 2 O 4 @HNTs nanocomposite were fully characterized by Fourier transform infrared (FT-IR) spectroscopy, field-emission scanning electron microscopy (FE-SEM) image, transmission electron microscope (TEM) images, energy-dispersive X-ray (EDX), X-ray diffraction (XRD) pattern, Brunauer-Emmett-Teller (BET) adsorption-desorption isotherm, thermogravimetric (TG) and vibrating sample magnetometer (VSM) curve analyses. The results confirmed that CuFe 2 O 4 with tetragonal structure, uniform distribution, and less agglomeration was located at HNTs. CuFe 2 O 4 @HNTs nanocomposite special features were high thermal stability, crystalline structure, and respectable magnetic property. SEM and TEM results showed the nanotube structure and confirmed the stability of basic tube in the synthetic process. Also, inner diameters of tubes were increased in calcination temperature at 500 °C. A good magnetic property of CuFe 2 O 4 @HNTs led to use it as a heterogeneous catalyst in the synthesis of pyrazolopyridine derivatives. High efficiency, green media, mild reaction conditions and easily recovery of the nanocatalyst are some advantages of this protocol.

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“…Ciprofloxacin attached to an APTES-functionalized halloysite helped to prevent complex formation with iron and other metal ions which are in contact with ciprofloxacin during drug delivery. The complexation studies between ciprofloxacin and iron revealed a 71 ± 1% decrease in undesirable drug absorbance [61]. Clay nanotubes were also investigated for the loading of volatile compounds, like essential oils, to prevent them from evaporation and losing antibacterial activity [62,63,64,65,66].…”

Section: Clay Nanotubes Loading With Antimicrobial Agentsmentioning

confidence: 99%

Antimicrobial Applications of Clay Nanotube-Based Composites

et al. 2019

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Halloysite nanotubes with different outer surface/inner lumen chemistry (SiO2/Al2O3) are natural objects with a 50 nm diameter hollow cylindrical structure, which are able to carry functional compounds both inside and outside. They are promising for biological applications where their drug loading capacity combined with a low toxicity ensures the safe interaction of these nanomaterials with living cells. In this paper, the antimicrobial properties of the clay nanotube-based composites are reviewed, including applications in microbe-resistant biocidal textile, paints, filters, and medical formulations (wound dressings, drug delivery systems, antiseptic sprays, and tissue engineering scaffolds). Though halloysite-based antimicrobial materials have been widely investigated, their application in medicine needs clinical studies. This review suggests the scalable antimicrobial nano/micro composites based on natural tubule clays and outlines research and development perspectives in the field.

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Development of a novel ‘nanocarrier’ system based on Halloysite Nanotubes to overcome the complexation of ciprofloxacin with iron: An in vitro approach

Cited by 87 publications

References 72 publications

Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications

Physicochemical and biological assessment of silver nanoparticles immobilized Halloysite nanotubes-based resin composite for dental applications

Mesoporous halloysite nanotubes modified by CuFe2O4 spinel ferrite nanoparticles and study of its application as a novel and efficient heterogeneous catalyst in the synthesis of pyrazolopyridine derivatives

Antimicrobial Applications of Clay Nanotube-Based Composites

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