Development of a novel synergistic thermosensitive gel for vaginal candidiasis: An in vitro, in vivo evaluation

Fenugreek gum derivatives with improved bioadhesion and controlled drug release: In vitro and in vivo characterization

“…The vaginal lavage samples were collected after washing the vaginal tract with 100 ml of saline at specified time intervals. This sample was then suitably diluted and spread on Sabouraud Dextrose Agar plates supplemented with chloramphenicol and incubated at 37 C for 48 h. Thereafter, CFU ml À1 were counted [31]. Rats were sacrificed at the end of the study, their vaginal tissue was isolated, fixed and observed under the microscope after staining.…”

Bioadhesive vaginal drug delivery of nystatin using a derivatized polymer: Development and characterization

“…The aim 29 of the present study was to develop and characterize locally acting, film formulation for the treatment 30 of candidiasis using a derivatized natural polymer. Derivatization of natural polymer was carried out 31 in order to introduce anionic character to an otherwise neutral polymer, so as to enhance its interaction 32 with vaginal mucous membrane along with inheriting the biocompatibility and nonirritant characteris- 33 tics of its parent polymer. A carboxymethyl derivative of fenugreek gum (CMFG) was prepared, and 34 characterized by DSC, FTIR and X-ray diffraction studies.…”

New strategies for local treatment of vaginal infections

“…Furthermore, TTO formulations, tested among different commercial intravaginal gels and pessaries, achieved the same activity against Candida albicans and nonalbicans as pure TTO [197]. [203] and to the own effect of nano-sized droplets of the emulsion that may improve permeation [99]. Also, it should be noted that essential oils (EO) or their components have been studied as permeation enhancers due to their ability of either promoting changes in the epithelium structures or modifying the partitioning of a drug [204].…”

“…Nano and microemulsions are systems composed of oil, water and a surfactant that differ from the current emulsions on their clear or translucentappearance and their high thermodynamically stability due to their peculiar structure[106]. These systems have been used to solubilize azoles in the oil phase allowing the development of vaginal formulations with improved efficacy and controlled drug release profile[99][100][101].…”