Development of a pH sensing membrane electrode based on a new calix[4]arene derivative

Ertürün, H. Elif Kormalı; Özel, Ayça Demirel; Sayın, Serkan; Kılıç, Esma

doi:10.1016/j.talanta.2014.10.032

Cited by 12 publications

(4 citation statements)

References 49 publications

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“…NaOH solution was added dropwise at the edge of the glass chamber, and the distances between adjacent electrodes were 3.6, 1.2, and 3.6 μm, respectively (Figure A). As shown in Figure B, these four sensors have synchronous responses and no significant delay because of the high mobility and rapid diffusion of the protonic charge. , The response time of the PANI microelectrode was nearly 1 s, faster than commercial pH glassy membrane electrodes (5–15 s). , Thus, our chip has the ability to real-time map the pHe spatial distribution in the cell microenvironment.…”

Section: Resultsmentioning

confidence: 89%

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High-Throughput and Real-Time Monitoring of Single-Cell Extracellular pH Based on Polyaniline Microarrays

Liu

Yin

et al. 2021

Anal. Chem.

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Real-time monitoring of extracellular pH (pHe) at the single-cell level is critical for elucidating the mechanisms of disease development and investigating drug effects, with particular importance in cancer cells. However, there are still some challenges for analyzing and measuring pHe due to the strong heterogeneity of cancer cells. Thus, it is necessary to develop a reliable method with good selectivity, reproducibility, and stability for achieving the pHe heterogeneity of cancer cells. In this paper, we report a high-throughput, real-time measuring technique based on polyaniline (PANI) microelectrode arrays for monitoring single-cell pHe. The PANI microelectrode array not only has a high sensitivity (57.22 mV/pH) ranging from pH 6.0 to 7.6 but also exhibits a high reliability (after washing, the PANI film was still smooth, dense, and with a sensitivity of 55.9 mV/pH). Our results demonstrated that the pHe of the cancer cell region is lower than that of the surrounding blank region, and pHe changes of different cancer cells exhibit significant cellular heterogeneity during cellular respiration and drug stimulation processes.

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Section: Resultsmentioning

confidence: 89%

“…8,35 The response time of the PANI microelectrode was nearly 1 s, faster than commercial pH glassy membrane electrodes (5−15 s). 36,37 Thus, our chip has the ability to real-time map the pHe spatial distribution in the cell microenvironment.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

High-Throughput and Real-Time Monitoring of Single-Cell Extracellular pH Based on Polyaniline Microarrays

Liu

Yin

et al. 2021

Anal. Chem.

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“…5b and 5c). These spots are distributed almost homogeneously and are referred to ion-pairs, which cause the sensitivity of the sensors towards CP cations [31]. However, the surface of the sensor Ⅱ seems rougher than the one of sensor Ⅳ.…”

Section: Glass Chip Pt Electrode Selective Pvc Membranementioning

confidence: 99%

Extended Gate Field Effect Transistor Based Sensor for Detection of Trace Amounts of Anti-Depressant Drug

2020

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Citalopram hydrobromide (CP) is a selective serotonin reuptake inhibitor for the treatment of the depressive disorder. In this work, a novel label-free recognition method based on an extended gate fieldeffect transistor (EGFET) for selective determination of CP is investigated. A Pt electrode covered by a modified PVC membrane, as the sensing part, is connected to the gate of a MOSFET transducer. Two types of PVC membranes containing ion-pairs, CP ion and tetraphenylborate or phosphotungstate ions (with different percentages), are used in this study. The obtained results indicate that the PVC membrane containing 7 % CP-tetraphenylborate has the highest sensitivity, with a detection limit of 10 -12 M. The sensor exhibits two linear response ranges, in the ranges of 10 -11 -10 -7 M and 10 -6 -10 -2 M, characterized by different sensitivities. The proposed method shows clear advantages in terms of increased accuracy, sensitivity, precision, and selectivity. The sensor is successfully applied to assay citalopram in tablets. The features of simplicity in preparation, fast response, capability for the miniaturization, and easy operatory, make the sensor a promising candidate for future integrated lab-on-chip devices for pharmaceutical quality control measurements.INDEX TERMS Citalopram, ion selective field-effect transistor, extended gate field-effect transistor, PVC

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“…Ayr›ca, mikroelektrot olarak üretilmeye ve in situ (yerinde) çal›flmalarda kullan›lmaya uygun de¤ildirler (4,5). Bu nedenle, son y›llarda, kat›-temasl› elektrotlar (SCE'lar) (6)(7)(8)(9)(10)(11)(12), kaplanm›fl tel elektrotlar (CWE'lar) (13,14), alan etkili transistörler (FET'ler) (15,16), nano çubuk elektrotlar (17,18) ve polimerik membran elektrotlar (PME'lar) (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33) (10,27,28), aminler (11)(12)(13)24), pillar [5]arenler (29), ve kaliks [4]arenler (30)(31)(32)(33) gösterilebilir. Literatür incelendi¤inde, baz› ilaç etken maddelerinin voltametrik/amperometrik sensörlerde duyarl›l›k sa¤lamak amac›yla kullan›ld›¤› (36, 37), ancak, pH duyarl› potansiyometrik PVC membran elektrot haz›rlanmas›nda iyonofor olarak kullan›lmad›¤› tespit edilmifltir.…”

Section: Introductionunclassified

BAZI İÇECEKLERDE TİTRASYON ASİTLİĞİNİN TAYİNİ İÇİN ZOFENOPRİL KALSİYUMA DAYANAN pH ELEKTROT YAPIMI

Ertürün¹

2017

GIDA

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ÖzBu çal›flmada, baz› içeceklerde titrasyon asitli¤inin tayini için kullan›labilecek zofenopril kalsiyum'a (ZFNCa) dayanan yeni bir PVC membran pH elektrot gelifltirilmifltir Elektrot, 20±1 °C'de, 1.7-9.5 pH aral›¤›nda, 44.1±1.7 mV/pH'lik bir e¤im göstermektedir. Ayr›ca, bu elektrodun, 15 s'lik cevap süresi ve en az 12 ayl›k ömürle, iyi bir tekrarlanabilirli¤e ve yeniden üretilebilirli¤e sahip oldu¤u gözlenmifltir. Ayn› zamanda, çeflitli iyonlar varl›¤›nda H + iyonuna karfl› iyi bir seçicilik gösterdi¤i belirlenmifltir. Önerilen elektrot kullan›larak, baz› içeceklerdeki (portakal suyu, elma suyu, gazl› içecek, bira, flarap ve sirke) titrasyon asitli¤inin tayininin yap›labilece¤i gösterilmifltir. Bulunan sonuçlar geleneksel cam pH elektrotla elde edilenlerle karfl›laflt›r›ld›¤›nda, %95 GS'de (güven seviyesi), aralar›nda anlaml› bir fark olmad›¤› belirlenmifltir. Sonuç olarak, ZFNCa'a dayanan bu elektrodun, içeceklerdeki titrasyon asitli¤i tayininde cam elektroda alternatif olarak baflar›yla kullan›labildi¤i görülmüfltür.Anahtar kelimeler: PVC membran, pH elektrot, zofenopril kalsiyum, potansiyometri, pH ölçümü, titrasyon asitli¤i CONSTRUCTION OF A pH ELECTRODE BASED ON ZOFENOPRIL CALCIUM FOR THE DETERMINATION OF TITRATABLE ACIDITY IN SOME BEVERAGES AbstractIn this study, a new PVC membrane pH electrode based on zofenopril calcium (ZFNCa) available for the determination of titratable acidity in some beverages was developed. The electrode exhibited a slope of 44.1±1.7 mV/pH in the pH range 1.7-9.5 at 20±1 °C. Furthermore, it was observed that the electrode had good repeatability and reproducibility with a response time of 15 s and a lifetime of at least 12 months. Also, it was found to display good selectivity for H + ions in the presence of various ions. The applicability of the proposed electrode for the determination of titratable acidity in some beverages (orange juice, apple juice, fizzy drink, beer, wine and vinegar) was illustrated. It was seen that there were no significant differences between the results obtained with the proposed electrode and the traditional glass pH electrode at the 95% CL (confidence level). As a consequence, it was seen that the electrode based on ZFNCa could be successfully used as an alternative for glass electrode to determine the titratable acidity in beverages.

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Development of a pH sensing membrane electrode based on a new calix[4]arene derivative

Cited by 12 publications

References 49 publications

High-Throughput and Real-Time Monitoring of Single-Cell Extracellular pH Based on Polyaniline Microarrays

High-Throughput and Real-Time Monitoring of Single-Cell Extracellular pH Based on Polyaniline Microarrays

Extended Gate Field Effect Transistor Based Sensor for Detection of Trace Amounts of Anti-Depressant Drug

BAZI İÇECEKLERDE TİTRASYON ASİTLİĞİNİN TAYİNİ İÇİN ZOFENOPRİL KALSİYUMA DAYANAN pH ELEKTROT YAPIMI

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