The purpose of the research is to study repellent efficacy of Cyfluthrin-based drug against dipterans in young cattle.Materials and methods. In July to September (the peak of attacks by dipterans), two farm scale trials were conducted on two farms in the Stavropol Territory to study repellent efficacy of Cyfluthrin-based drug against dipterans on young cattle. The examining of the animals at the beginning of the trial found that all of them were attacked by dipterans including horseflies, gadflies, mosquitoes, midges and zoophilous flies with 100% infection prevalence and an abundance index of 23.0–35.5 specimens on one animal. The animals in two study groups received the test drug on dry, intact skin of the back, along the spine from the withers to the rump, once at a dose of 0.2 mL of the drug per 10 kg of animal weight. The drug efficacy was assessed based on a decrease in the number or absence of dipterans in the treated animals as compared to the untreated animals (control groups) before the trial and at day 3, 7, 14, 21, 28 and 35. We used a visual inspection technique and counting of the number of dipterans on an animal for 3 minutes.Results and discussion. The use of the Cyfluthrin-based drug at a dose of 0.2 mL per 10 kg of animal weight showed a 100% repellent effect against dipterans. The repellent index was in the range of 78.6–96.4% for 28 days, which is higher than 70%, which indicates a high repellent effect of the drug against dipterans.