Development of chemically synthesized hydroxyapatite composite with reduced graphene oxide for enhanced mechanical properties

Flora, Bableen; Kumar, Rohit; Tiwari, Preeti; Kumar, Akhilesh; Ruokolainen, Janne; Narasimhan, Ashwin Kumar; Kesari, Kavindra Kumar; Gupta, Piyush Kumar; Singh, Anjuvan

doi:10.1016/j.jmbbm.2023.105845

Cited by 11 publications

(3 citation statements)

References 34 publications

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“…Zinc-based biomaterials such as Zn-Sr and Zn-Mg (1.5 at.%) are used in orthopedic devices, cardiovascular stents, and other rigid medical applications with microhardness, strength, and elongation greater than 70 kg mm −2 , 220 MPa, and 15%, respectively [180]. The compressive strength of hydroxyapatite and rGO composites prepared by ball milling is a maximum of about 10.39 ± 0.43 MPa, which is widely applied in orthopedics and dentistry as bio-cement [181]. To address the low mechanical strength, LMs are often combined with hydrogel polymers that provide appropriate mechanical strength to form composites.…”

Section: Discussionmentioning

confidence: 99%

Advances of liquid metal hydrogel composites in biomedical applications

Chen,

Yan,

Zhang

et al. 2023

Biomed. Mater.

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Liquid metals (LMs) and hydrogels each represent advanced frontiers in emerging biomaterials and biomedicine. In particular, LMs, which possess liquid and metallic properties at normal temperature and pressure, are a new type of conductive material that has gained increasing attention. When integrated into hydrogel polymers, LMs act exceptionally as an "active" filler and/or responsive element. The presence of LMs in these composites endows the liquid metal hydrogel composites (LMHGs) with intriguing properties such as self-healing, flexibility, responsiveness, and thermal and electrical conductivity. These properties significantly broaden their applications in various fields. This review introduces the featured performances of LMs, as well as emphatically summarizes advanced biomedical applications of LMHGs involving medical electronics, biomedical engineering, and soft electronics actuators. The present opportunities and challenges associated with the biological applications of LMHGs are also discussed.

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Section: Discussionmentioning

confidence: 99%

Advances of liquid metal hydrogel composites in biomedical applications

Chen,

Yan,

Zhang

et al. 2023

Biomed. Mater.

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“…Metallopolymer nanocomposites are hybrid nanomaterials that combine metal components’ electrical, optical, catalytic, and thermal properties with the polymer component’s flexibility, solubility, and manufacturability. − These nanomaterials have been broadly utilized in biomedical applications because of their superior properties. Silver NP–polyvinylpyrrolidone–[meglumine antimoniate (Glucantime)]) nanocomposite, abbreviated as Ag NPs-PVP-MA, exhibited considerable antileishmanial activity against Leishmania amazonensis infection in vitro.…”

Section: Nanodrug Delivery Systems Utilized During Leishmaniasis Trea...mentioning

confidence: 99%

Revolutionizing Leishmaniasis Treatment with Cutting Edge Drug Delivery Systems and Nanovaccines: An Updated Review

Tambe,

Nag,

Pandya

et al. 2024

ACS Infect. Dis.

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Leishmaniasis, one of the most overlooked tropical diseases, is a life-threatening illness caused by the parasite Leishmania donovani that is prevalent in underdeveloped nations. Over 350 million individuals in more than 90 different nations worldwide are at risk of contracting the disease, which has a current fatality rate of 50 000 mortalities each year. The administration of liposomal Amp B, pentavalent antimonials, and miltefosine are still considered integral components of the chemotherapy regimen. Antileishmanial medications fail to treat leishmaniasis because of their numerous drawbacks. These include inadequate effectiveness, toxicity, undesired side effects, drug resistance, treatment duration, and cost. Consequently, there is a need to overcome the limitations of conventional therapeutics. Nanotechnology has demonstrated promising outcomes in addressing these issues because of its small size and distinctive characteristics, such as enhanced bioavailability, lower toxicity, biodegradability, and targeted drug delivery. This review is an effort to highlight the recent progress in various nanodrug delivery systems (nDDSs) over the past five years for treating leishmaniasis. Although the preclinical outcomes of nDDSs have shown promising treatment for leishmaniasis, further research is needed for their clinical translation. Advancement in three primary priority domains�molecular diagnostics, clinical investigation, and knowledge dissemination and standardization�is imperative to propel the leishmaniasis field toward translational outcomes.

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“…3 Metal (M)/metal oxide (MO) NPs can be synthesized by chemical as well as biological methods using different metal salts. 4 A few examples of such NPs are ZnFe 2 O 4 , MnFe 2 O 4 , 5 ZnO, Fe 3 O 4 , Fe 2 O 4 , CuO, ZnO, Ag, Cu, and Au. 6,7 These NPs possess surface plasmon resonance properties and are flexible in surface functionalization.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

Chauhan,

Naik,

Kumar

et al. 2024

ACS Omega

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Recently, the use of hybrid nanomaterials (NMs)/nanocomposites has widely increased for the health, energy, and environment sectors due to their improved physicochemical properties and reduced aggregation behavior. However, prior to their use in such sectors, it is mandatory to study their toxicological behavior in detail. In the present study, a ZnFe 2 O 4 @poly(tBGE-alt-PA) nanocomposite is tested to study its toxicological effects on a fruit fly model. This nanocomposite was synthesized earlier by our group and physicochemically characterized using different techniques. In this study, various neurological, developmental, genotoxic, and morphological tests were carried out to investigate the toxic effects of nanocomposite on Drosophila melanogaster. As a result, an abnormal crawling speed of third instar larvae and a change in the climbing behavior of treated flies were observed, suggesting a neurological disorder in the fruit flies. DAPI and DCFH-DA dyes analyzed the abnormalities in the larva's gut of fruit flies. Furthermore, the deformities were also seen in the wings and eyes of the treated flies. These obtained results suggested that the ZnFe 2 O 4 @poly(tBGE-alt-PA) nanocomposite is toxic to fruit flies. Moreover, this is essential to analyze the toxicity of this hybrid NM again in a rodent model in the future.

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Development of chemically synthesized hydroxyapatite composite with reduced graphene oxide for enhanced mechanical properties

Cited by 11 publications

References 34 publications

Advances of liquid metal hydrogel composites in biomedical applications

Advances of liquid metal hydrogel composites in biomedical applications

Revolutionizing Leishmaniasis Treatment with Cutting Edge Drug Delivery Systems and Nanovaccines: An Updated Review

In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

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Development of chemically synthesized hydroxyapatite composite with reduced graphene oxide for enhanced mechanical properties

Cited by 11 publications

References 34 publications

Advances of liquid metal hydrogel composites in biomedical applications

Advances of liquid metal hydrogel composites in biomedical applications

Revolutionizing Leishmaniasis Treatment with Cutting Edge Drug Delivery Systems and Nanovaccines: An Updated Review

In Vivo Toxicological Analysis of the ZnFe2O4@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

Contact Info

Product

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In Vivo Toxicological Analysis of the ZnFe₂O₄@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly