Alzheimer’s, a progressive neurodegenerative disease affects brain and neurons through enormous reduction in nerve cell regenerative capacity. Dementia and impairment of cognitive functions are more prevalent in Alzheimer’s disease (AD) patients in both industrialized and non-industrialized countries. Various factors play significant role in molecular cascades that leads to neuronal inflammation, dementia and thereby AD progression. Current medications are symptomatic that alleviates pain while lack in absolute cure, urging researchers to explore targets and therapeutics. Interestingly, nanomedicines developed due to the onset of nanotechnology, are being extensively investigated for the treatment of AD. This review presents the advancement in nanotherapeutic strategies, involving the emergence of nanomaterials that offers advantage to pass through the blood-brain barrier and acts as a therapeutic modality against AD.

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Rapid tooling using additive manufacturing, or 3D printing, is an emerging manufacturing technology that has the potential to revolutionize the production of complex parts using only a computer and a design program. Lightweight structures with excellent dimensional precision and lower cost for customizable geometries are possible with these printed parts. In recent years, inherent constraints of polymers, metals, and ceramics have pushed researchers toward superior alternative composite materials to boost mechanical and other critical features; current 3D printing research follows this route from neat to composite materials. The characteristics, performance, and future uses of composite materials produced using additive manufacturing methods are discussed in this review. In addition, to discuss the state of the art in additive manufacturing, this article also fabricated many technologies, including robotics, machine learning, organ-on-a-chip, and 4D bioprinting.

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