Recent Updates on Metal-Polymer Nanocomposites in 3D Bioprinting for Tissue Engineering Applications

Abstract

Rapid tooling using additive manufacturing, or 3D printing, is an emerging manufacturing technology that has the potential to revolutionize the production of complex parts using only a computer and a design program. Lightweight structures with excellent dimensional precision and lower cost for customizable geometries are possible with these printed parts. In recent years, inherent constraints of polymers, metals, and ceramics have pushed researchers toward superior alternative composite materials to boost mechanical and other critical features; current 3D printing research follows this route from neat to composite materials. The characteristics, performance, and future uses of composite materials produced using additive manufacturing methods are discussed in this review. In addition, to discuss the state of the art in additive manufacturing, this article also fabricated many technologies, including robotics, machine learning, organ-on-a-chip, and 4D bioprinting.

In Vivo Toxicological Analysis of the ZnFe2O4@poly(tBGE-alt-PA) Nanocomposite: A Study on Fruit Fly

“…Generally, metallopolymer composites possess the combined properties of both polymers such as flexibility, solubility, biodegradability, and biocompatibility and metal NPs like thermostability, electrical, optical, and catalytic properties. 13−15 They have been utilized for biosensing, bioimaging, bioelectronics, drug delivery, tissue engineering, 16 and bioremediation applications. 9−11 The polymer components of the metallopolymer nanocomposite are amphiphilic, biodegradable, and cytocompatible in nature.…”

“…Generally, metallopolymer composites possess the combined properties of both polymers such as flexibility, solubility, biodegradability, and biocompatibility and metal NPs like thermostability, electrical, optical, and catalytic properties. − They have been utilized for biosensing, bioimaging, bioelectronics, drug delivery, tissue engineering, and bioremediation applications. − The polymer components of the metallopolymer nanocomposite are amphiphilic, biodegradable, and cytocompatible in nature. Among different polymers, polyesters have been used majorly to fabricate metallopolymer nanocomposites. − Examples of such polyesters are poly­(ε-caprolactone), poly­(lactic- co -glycolic acid), poly­(lactic acid), and poly­(glycolic acid). , In the past few years, several other polyesters have been also synthesized using a metal-free copolymerization approach, i.e., cost-effective, eco-friendly, and fast. , By this reaction, the obtained polyesters are free from metal contamination and have been utilized for drug delivery applications. − Next, the metal components of the metallopolymer nanocomposite are biocompatible, hemocompatible, and catalytic in nature.…”