Development of Dermal Films Containing Miconazole Nitrate

Bîrsan, Magdalena; Apostu, Mihai; Todoran, Nicoleta; Antonoaea, Paula; Rusu, Aura; Ciurba, Adriana

doi:10.3390/molecules23071640

Cited by 13 publications

(18 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It was observed that SI was ALG concentration-dependent -formulation P3 with high ALG concentration possessed higher SI properties. Similarly, Sarheed et al noted that swelling ability was increased with the Folding endurance was measured to determine the rupturing resistance of designed buccal films, and, in all formulations, it was over 100 times, exhibiting good flexibility [18].…”

Section: Swelling Studymentioning

confidence: 97%

“…In addition, it was observed that placebo formulations (P1-P4) were characterized by higher TS, E%, and E values than POS-loaded formulations (F1-F4), proving that the addition of the drug substance weakens mechanical properties. Folding endurance was measured to determine the rupturing resistance of designed buccal films, and, in all formulations, it was over 100 times, exhibiting good flexibility [18].…”

Section: Mechanical Propertiesmentioning

confidence: 99%

See 1 more Smart Citation

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole

et al. 2019

View full text Add to dashboard Cite

Sodium alginate and its oligosaccharides through potential antifungal properties might improve the activity of antifungal drugs enhancing their efficacy and potentially reducing the frequency of application. Mucoadhesive buccal films are oral dosage forms designed for maintaining both local or systemic drug effects and seem to be a very promising alternative to conventional oral formulations. Hence, in this study, mucoadhesive buccal films based on the alginate and its oligosaccharide oligomer composed predominantly of mannuronic acid for the administration of posaconazole-antifungal drug from the azole group were developed. As the polymer gelation method, a relatively new freeze-thaw technique was chosen. All prepared formulations were examined for pharmaceutical tests, swelling, mechanical, and mucoadhesive properties. In addition, the influence of sodium alginate (ALG) and alginate oligosaccharides (OLG) on POS antifungal activity on Candida species was performed. It was observed that film formulation containing 1% ALG and 1% OLG (F2) was characterized by optimal mucoadhesive and swelling properties and prolonged drug release up to 5 h. Additionally, it was shown that OLG affected the growth reduction of all tested Candida spp. The obtained data has opened the way for future research for developing OLG-based dosage forms, which might increase the activity of antifungal drugs.

show abstract

Section: Swelling Studymentioning

confidence: 97%

Section: Mechanical Propertiesmentioning

confidence: 99%

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The increasing number of stress conditions caused by the diversification of activities conducted in modern society, associated with the occurrence of the corresponding pollution factors and the diversity of microbial agents, in particular caused by the increased mobility of people all over the world, led, in addition to the appearance of new diseases, to the occurrence and the diversification of fungal infections. The development of pharmaceutical forms with miconazole nitrate (MN) for external use can bring various benefits to patients presenting resistance to classic antifungal forms because of the fact that the active drug lasts longer in the tissue, acting as a slow release product [7,8]. Repeated administration leads to an accumulating effect of multiple doses in the stratum corneum, which causes the disappearance of fungal infection [6,28].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Miconazole Nitrate Permeability Through Biological Membrane From Dermal Systems

Bîrsan¹

2020

FARMACIA

Self Cite

View full text Add to dashboard Cite

The development of pharmaceutical products with miconazole nitrate (MN) can bring various benefits to patients of whom fungal infections are resistant to classic antifungal formulas. In medical practice, dermal systems, in the form of polymeric films, represent an alternative to other medical products. The proposed dermal films contain hydroxyethyl cellulose (HEC) as a hydrophilic and bioadhesive matrix polymer, with the addition of polyethylene glycol (PEG) as a low-absorption promoter, so that the antifungal have a slow penetration towards the dermis. This study aims to evaluate the in vitro permeability of MN through biological membrane (pig ear skin) at pH 7.4, during its release from two polymeric films. In vitro pig ear skin permeation studies indicated that the amount of the drug released after 24 h was 40% in the case of formulation FI and 32% in the case of formulation FII from the initial dose (40 mg). The concentration of 40% MN released can be considered an appropriate antifungal dose, with the benefit of being accumulated in the stratum corneum where it is maintained for up to 4 days. RezumatDezvoltarea de forme farmaceutice cu nitrat de miconazol (MN) poate aduce numeroase beneficii pacienților care au dezvoltat rezistență clinică la formulările antifungice clasice. În practica medicală, sistemele dermice formulate ca filme polimerice reprezintă o alternativă de administrare față de alte produse medicamentoase. Filmele dermice propuse conțin hidroxietilceluloză, un polimer bioadeziv formator de matriță, în asociere cu polietilenglicol ca promotor cu proprietăți moderate de penetrare cutanată, astfel încât substanța activă să poată penetra lent țesutul cutanat. Acest studiu își propune evaluarea in vitro a permeației MN prin membrană biologică (piele de ureche de porc) la pH 7,4 din două tipuri de filme polimerice. Studiile de permeație in vitro prin membrană biologică indică o eliberare de 40% a substanței active după 24 de ore (FI), respectiv 32% (FII). Cantitatea de MN eliberată (40%) asigură eficiența antifungică, substanța activă acumulându-se în stratul cornos unde se menține până la 4 zile după prima aplicare.

show abstract

“…Recently, in situ film-forming systems (on the skin, after spreading in a thin layer) -FFSs which form a film on the skin after spreading in a thin layer, have been developed as a new approach to be used as an alternative to both conventional and transdermal topical formulations [12]. In this paper, four pharmaceutical substances were selected as potential active ingredients ( Figure 1) that could be useful in the form of film-forming systems with dermal and/or transdermal delivery: adapalene (ADA) [23,84], levofloxacin (LEV) [36,69], meloxicam (MEL) [16], and miconazole nitrate (MIC) [10]. These therapeutic agents have some significant physicochemical properties (Table I) based on which they can be individually used to treat various skin diseases: skin candidiasis, acne vulgaris, other skin infections, etc.…”

Section: Introductionmentioning

confidence: 99%

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

Rusu¹

2020

FARMACIA

Self Cite

View full text Add to dashboard Cite

Adapalene (ADA), levofloxacin (LEV), meloxicam (MEL) and miconazole nitrate (MIC) were selected as potential active ingredients for film systems with dermal or transdermal delivery. This study aimed to evaluate the compatibility of four binary mixtures-ADA and LEV (M1), ADA and MIC (M2), LEV and MEL (M3), and LEV and MIC (M4)combinations for new bioadhesive polymeric matrix dermal systems produced by the casting solvent evaporation technique. The Fouriertransform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and molecular modelling (MM) were used to characterise and evaluate the compatibility between the selected active substances. In the FTIR data, M1, M2, and M4 mixtures presented a good compatibility. DSC revealed different chemical interactions as the temperature rose above 160°C, especially for M3 and M4. Through MM technique, interactions were found on the M2 and M3 mixtures. Following the correlation of all obtained results, the best compatibility was found to be on M1 and M4 combinations. Rezumat Adapalenul (ADA), levofloxacina (LEV), meloxicamul (MEL) şi nitratul de miconazol (MIC) au fost selectate ca potenţiale ingrediente active în sistemele de tip film cu eliberare dermică sau transdermică. Scopul acestui studiu este de a evalua compatibilitatea a patru amestecuri binare-ADA şi LEV (M1), ADA şi MIC (M2), LEV şi MEL (M3), şi LEV şi MIC (M4)-combinaţii pentru noi sisteme dermice de tip matriţă polimerică bioadezivă produse prin tehnica de turnare şi evaporare a solventului. Pentru a caracteriza şi evalua compatibilitatea dintre substanţele active selectate au fost utilizate spectroscopia cu transformată Fourier (FTIR), calorimetria cu scanare diferenţială (DSC) şi modelarea moleculară (MM). Din datele FTIR, amestecurile M1, M2 şi M4 au fost compatibilite. DSC a arătat diferite interacţiuni chimice, în special pentru M3 şi M4, la temperaturi mai mari de 160°C. Prin metoda MM au fost semnalate interacţiuni în combinaţiile M2 şi M3. Ca urmare a corelării tuturor rezultatelor obţinute, cea mai bună compatibilitate a fost găsită în combinaţiile M1 şi M4.

show abstract

Development of Dermal Films Containing Miconazole Nitrate

Cited by 13 publications

References 40 publications

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole

Alginate Oligosaccharides Affect Mechanical Properties and Antifungal Activity of Alginate Buccal Films with Posaconazole

Evaluation of Miconazole Nitrate Permeability Through Biological Membrane From Dermal Systems

Compatibility Study of Four Binary Combinations of Active Ingredients for Dermal Film Forming Systems

Contact Info

Product

Resources

About