Development of interdigitated arrays coated with functional polyaniline/MWCNT for electrochemical biodetection: Application for human papilloma virus

Tran, Lam Dai; Nguyen, Dzung Tuan; Nguyen, Binh Hai; Quan, Do Phuc; Nguyen, Huy H.

doi:10.1016/j.talanta.2011.06.048

Cited by 62 publications

(28 citation statements)

References 23 publications

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“…Besides the already mentioned gold electrodes, in the last five years, label-free electrochemical microarrays have been used extensively for the detection of different HPV16 antibodies [34,35,37,39]. These label-free platforms are developed through the immobilization of the biorecognition probe atop of an interdigitated gold or platinum electrode.…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

“…The signal transducers are widely diverse, pencil graphite surfaces [30,33], carbon surfaces modified with linear polysaccharides [35], plain glassy carbon surface [34], or poly(methylmethacrylate) substrate recovered with a thin gold film [38]. Additionally, more sophisticated nanostructured ones as graphene/gold nanoparticles (AuNPs), nanorod/poly(thionine), or polyaniline-multiwall carbon nanotube (MWCNT) film [39,68] have been used to construct biosensors committed to detect and differentiate HPV strains. These platforms facilitate the study of the output signal by cyclic voltammetry (CV), square wave voltammetry (SWV) [33,35], differential pulse voltammetry (DPV) [30,68], and electrochemical impedance spectroscopy (EIS) [68].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

“…From the presented alternatives, we highlight the use of nanomaterials, particularly carbon nanotubes and gold nanoparticles, as strategic components to improve the analytical performance of electrochemical biosensors [38,39,68,89]. The cited nanomaterials exhibit not only combined dielectric and optical properties but also a high surfaceto-volume ratio, biocompatibility, and high conductivity, allowing direct charge transfer between the biomolecule and the electrode surface [90][91][92].…”

Section: Electrochemical Biosensorsmentioning

confidence: 99%

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Trends in Biosensors for HPV: Identification and Diagnosis

et al. 2015

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The conventional methodologies used for the detection of human papillomavirus (HPV) present actually robust and reproducible advantages. However, at the same time, they involve complex protocols that sometimes are difficult to popularize. Over the first half of XX century, the adequate treatment of complex and delicate processes from a simple instrumental base seemed a fundamental and intrinsic contradiction. However, interdisciplinary trends have allowed the manipulation of tissues, proteins, and nucleic acids through innovative increasingly smaller devices. The proper diagnosis of HPV has seen great advances since biosensor researchers are employing its virus strains as models to study the interactions between the biorecognition element and the transducer. Additionally, all recent improvements and trends that material sciences, biotechnology, and data processing scientists excel for biosensors can be applied for the HPV detection platforms. In this review, we highlight the recent trends on materials, nanomaterials, and transducers for the specific detection and differentiation of HPV strains. The most influential methods for the detection and identification of these papillomaviruses include optical, electrochemical, and piezoelectric transducers; we will visit their sensibility and advantages. Additionally, we highlight the factors that contributed to the increasing importance of these biodevices as potential substitutes to conventional diagnostic methods.

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Section: Electrochemical Biosensorsmentioning

confidence: 99%

Section: Electrochemical Biosensorsmentioning

confidence: 99%

Section: Electrochemical Biosensorsmentioning

confidence: 99%

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Trends in Biosensors for HPV: Identification and Diagnosis

et al. 2015

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“…An interdigitated electrode array covered with an electrolyzed polyanilinemultiwalled carbon nanotube film (PANi-MWCNT) was developed for HPV-16 diagnosis [63]. This electrochemical detection was based on immuno-reaction between an immobilized antigen aptamer HPV-16-L1 on the array surface and an antibody of HPV-16 present in the sample.…”

Section: B Electrical Detection Technologiesmentioning

confidence: 99%

Advances in Nanotechnology and Microfluidics for Human Papillomavirus Diagnostics

et al. 2015

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| Human papillomavirus (HPV) has been shown in many studies as a prerequisite for the development of cervical cancer, which is the second most common and predominant form of malignancy among women worldwide, with 270 000 deaths (80% of whom live in developing countries) and 500 000 new cases per year. Early diagnosis of cervical cancer allows patients to be fully treated. Therefore, there is high clinical utility of HPV diagnostics even with binary positive/ negative indication of the presence of HPV in patient samples.Although the Pap smear is widely used for cervical cancer screening, this method still suffers from low sensitivity and specificity. Thus, simple, rapid and inexpensive diagnostic methods are needed to detect the etiology of cervical cancer, i.e., HPV, especially high-risk oncogenic subtypes 16 and 18.Here, we review the existing assays and platforms employed for HPV diagnosis, and highlight recent advances in nanotechnology and microfluidics that potentially enable new approaches for HPV diagnosis.

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“…2009;Srivastava, Kumar, Singh, Singh, & Vijay, 2011;Tran, Nguyen, Nguyen, Do, & Nguyen, 2011). As a sensor for nicotine, the key element of doped, electrically conductive PANi is the presence of protonated nitrogen atoms that give up a proton to nicotine, a base, which is adsorbed to the film from the nascent vapor.…”

Section: Introductionmentioning

confidence: 99%

Detection of Secondhand Cigarette Smoke via Nicotine Using Conductive Polymer Films

Liu

Antwi-Boampong

BelBruno

et al. 2013

Nicotine & Tobacco Research

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The 2006 U.S. Surgeon General's Report found that there is no safe level of exposure to secondhand smoke (SHS). Many smokers attempt to protect others from exposure to SHS; however, it is difficult to assess effectiveness of these behavior changes. There is a need for personal monitoring devices that provide real-time SHS exposure data; at present, there is no device that measures ambient nicotine levels in real time. The development of such a sensor is the objective of this research.

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Development of interdigitated arrays coated with functional polyaniline/MWCNT for electrochemical biodetection: Application for human papilloma virus

Cited by 62 publications

References 23 publications

Trends in Biosensors for HPV: Identification and Diagnosis

Trends in Biosensors for HPV: Identification and Diagnosis

Advances in Nanotechnology and Microfluidics for Human Papillomavirus Diagnostics

Detection of Secondhand Cigarette Smoke via Nicotine Using Conductive Polymer Films

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