Development of Magnetic Nanostructured Silica-Based Materials as Potential Vectors for Drug-Delivery Applications

Arruebo, Manuel; Galán, Marta; Navascués, Nuria; Téllez, Carlos; Marquina, C.; Ibarra, Alfonso; Santamarı́a, Jesús

doi:10.1021/cm051646z

Cited by 224 publications

(111 citation statements)

References 29 publications

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“…[14,[24][25][26][27][28][29] However, dispersing magnetic nanoparticles in the pores of mesoporous silicas could result in the blocking of pores, lowering surface area, small pore volume, and the distortion of pore structure. [11,24,25,30] In Schuth group's work, magnetic mesoporous silica with an unobstructed pore system was fabricated by grafting magnetic nanocrystals on the outer surface of SBA-In this paper, we report a novel synthesis and selective bioseparation of the composite of Fe 3 O 4 magnetic nanocrystals and highly ordered MCM-41 type periodic mesoporous silica nanospheres. Monodisperse superparamagnetic Fe 3 O 4 nanocrystals were synthesized by thermal decomposition of iron stearate in diol in an autoclave at low temperature.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and Size‐Selective Bioseparation of Magnetic Silica Nanospheres with Highly Ordered Periodic Mesostructure

Zhang

Qiao

Jin

et al. 2008

Adv Funct Materials

180

124

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In this paper, we report a novel synthesis and selective bioseparation of the composite of Fe3O4 magnetic nanocrystals and highly ordered MCM‐41 type periodic mesoporous silica nanospheres. Monodisperse superparamagnetic Fe3O4 nanocrystals were synthesized by thermal decomposition of iron stearate in diol in an autoclave at low temperature. The synthesized nanocrystals were encapsulated in mesoporous silica nanospheres through the packing and self‐assembly of composite nanocrystal–surfactant micelles and surfactant/silica complex. Different from previous studies, the produced magnetic silica nanospheres (MSNs) possess not only uniform nanosize (90 ∼ 140 nm) but also a highly ordered mesostructure. More importantly, the pore size and the saturation magnetization values can be controlled by using different alkyltrimethylammonium bromide surfactants and changing the amount of Fe3O4 magnetic nanocrystals encapsulated, respectively. Binary adsorption and desorption of proteins cytochrome c (cyt c) and bovine serum albumin (BSA) demonstrate that MSNs are an effective and highly selective adsorbent for proteins with different molecular sizes. Small particle size, high surface area, narrow pore size distribution, and straight pores of MSNs are responsible for the high selective adsorption capacity and fast adsorption rates. High magnetization values and superparamagnetic property of MSNs provide a convenient means to remove nanoparticles from solution and make the re‐dispersion in solution quick following the withdrawal of an external magnetic field.

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Section: Introductionmentioning

confidence: 99%

Fabrication and Size‐Selective Bioseparation of Magnetic Silica Nanospheres with Highly Ordered Periodic Mesostructure

Zhang

Qiao

Jin

et al. 2008

Adv Funct Materials

180

124

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“…13 There are few reports using silica-coated magnetic nanoparticle (SiO 2 -MNP) in targeted drug-delivery systems. [14][15][16] Typically, there are two kinds of methods by which to prepare SiO 2 -MNP. The first method is based on the microemulsion system, in which the Fe 3 O 4 -MNP is restricted in the water droplets dispersed in a continuous organic phase and SiO 2 -MNP is formed by hydrolysis and condensation of tetraethoxysilane (TEOS), which diffuses from the surrounding organic phase into the water droplet.…”

Section: Introductionmentioning

confidence: 99%

Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle

Chen¹,

Yang²,

Ma³

et al. 2012

IJN

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Background and methods: Silica-coated magnetic nanoparticle (SiO 2 -MNP) prepared by the sol-gel method was studied as a nanocarrier for targeted delivery of tissue plasminogen activator (tPA). The nanocarrier consists of a superparamagnetic iron oxide core and an SiO 2 shell and is characterized by transmission electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction, superconducting quantum interference device, and thermogravimetric analysis. An amine-terminated surface silanizing agent (3-aminopropyltrimethoxysilane) was used to functionalize the SiO 2 surface, which provides abundant -NH 2 functional groups for conjugating with tPA. Results: The optimum drug loading is reached when 0.5 mg/mL tPA is conjugated with 5 mg SiO 2 -MNP where 94% tPA is attached to the carrier with 86% retention of amidolytic activity and full retention of fibrinolytic activity. In vitro biocompatibility determined by lactate dehydrogenase release and cell proliferation indicated that SiO 2 -MNP does not elicit cytotoxicity. Hematological analysis of blood samples withdrawn from mice after venous administration indicates that tPA-conjugated SiO 2 -MNP (SiO 2 -MNP-tPA) did not alter blood component concentrations. After conjugating to SiO 2 -MNP, tPA showed enhanced storage stability in buffer and operation stability in whole blood up to 9.5 and 2.8-fold, respectively. Effective thrombolysis with SiO 2 -MNP-tPA under magnetic guidance is demonstrated in an ex vivo thrombolysis model where 34% and 40% reductions in blood clot lysis time were observed compared with runs without magnetic targeting and with free tPA, respectively, using the same drug dosage. Enhanced penetration of SiO 2 -MNP-tPA into blood clots under magnetic guidance was confirmed from microcomputed tomography analysis. Conclusion: Biocompatible SiO 2 -MNP developed in this study will be useful as a magnetic targeting drug carrier to improve clinical thrombolytic therapy.

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“…Se ha comprobado que la sílice es un excelente material para aplicaciónes biomédicas, atendiendo a su buena biocompatibilidad (Arruebo et al, 2006;Barbé et al, 2004;Slowing et al, 2007Slowing et al, , 2008Zhao et al, 2005).…”

Section: Introducción Objetivosunclassified

Maghemite Functionalization for Antitumor Drug Vehiculization

2012

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In this paper we describe the preparation and characterization of magnetic nanocomposites designed for applications in targeted drug delivery. Combining superparamagnetic behavior with proper surface functionalization in a single entity makes it possible to have altogether controlled location and drug loading, and release capabilities. The colloidal vehicles consist of maghemite (γ-Fe2O3) cores surrounded by a gold shell through an intermediate silica coating. The external Au layer confers the particles a high degree of biocompatibility and reactive sites for the transported drug binding. In addition, it permits to take advantage of the strong optical resonance, making it easy to visualize the particles or even control their payload release through temperature changes. The results of the analysis of relaxivity demonstrate that these nanostructures can be used as T 2 contrast agents in magnetic resonance imaging (MRI), but the magnetic cores will be mainly useful in manipulating the particles using external magnetic fields. We describe how optical absorbance and electrokinetic data provide a followup of the progress of the nanostructure formation. Additionally, these techniques, together with confocal microscopy, are employed to demonstrate that the component nanoparticles are capable of loading significant amounts of the antitumor drug doxorubicin, very efficient in the chemotherapy of a wide range of tumors. Colon adenocarcinoma cells were used to test the in vitro release capabilities of the drug-loaded nanocomposites.

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Development of Magnetic Nanostructured Silica-Based Materials as Potential Vectors for Drug-Delivery Applications

Cited by 224 publications

References 29 publications

Fabrication and Size‐Selective Bioseparation of Magnetic Silica Nanospheres with Highly Ordered Periodic Mesostructure

Fabrication and Size‐Selective Bioseparation of Magnetic Silica Nanospheres with Highly Ordered Periodic Mesostructure

Targeted delivery of tissue plasminogen activator by binding to silica-coated magnetic nanoparticle

Maghemite Functionalization for Antitumor Drug Vehiculization

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