Development of microcirculation in full thickness autogenous skin grafts in mice

Zarem, Harvey A.; Zweifach, BW; McGehee, JM

doi:10.1152/ajplegacy.1967.212.5.1081

Cited by 58 publications

(24 citation statements)

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“…According to earlier studies demonstrating dermal vessel growth at a rate of 5 m/hour, a 300-m skin graft may be pierced by newly formed microvessels within 72 hours. 21 In contrast to this would stand the complete de novo vascularization of the graft by vessels originating from the wound bed, a process that most likely would involve several weeks. 22 In a previous study, it was suggested that the autochthonous vessels of the graft provide merely a conduit or sheath for the angiogenic vessels from the wound bed.…”

Section: Discussionmentioning

confidence: 99%

Temporary Angiogenic Transformation of the Skin Graft Vasculature after Reperfusion

Lindenblatt¹,

Platz

Althaus

et al. 2010

Plastic and Reconstructive Surgery

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The authors were able to show for the first time a temporary angiogenic response within the capillaries of the skin graft. This most likely represents a reaction to reperfusion allowing the supply of proangiogenic factors to the hypoxic skin graft. The detection of an angiogenic response within the graft capillaries is for the first time made possible in the newly developed model and is therefore completely novel.

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Section: Discussionmentioning

confidence: 99%

Temporary Angiogenic Transformation of the Skin Graft Vasculature after Reperfusion

Lindenblatt¹,

Platz

Althaus

et al. 2010

Plastic and Reconstructive Surgery

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“…Apart from the earlier mentioned reports about direct vascular connections in various types of grafts there are also critical studies claiming the improbability of end-to-end anastomoses (Zarem 1965(Zarem , 1970. Even if the osteocyte canaliculae do permit diffusion through tissue fluid, the calcified ground substance in bone acts as a barrier to the primary tissue fluid circulation (Ham 1952), further diminishing the chances for vascular anastomoses in this special tissue.…”

Section: Revascularixation Grafted Tissuementioning

confidence: 99%

In VivoStudies of Bone Grafts: The Possibility of Vascular Anastomoses in Healing Bone

Albrektsson

1980

Acta Orthopaedica Scandinavica

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“…Revascularization and angiogenesis between the recipient bed and the graft begins within 48 to 72 hours after grafting. [1][2][3] Depending on the thickness of the graft, some degree of circulation usually is restored by the fourth to seventh day after grafting. 4 However, it is unknown whether autonomic control of the cutaneous vasculature, with respect to thermoregulatory responses, is restored in healed split-thickness grafts.…”

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confidence: 99%

Impaired Cutaneous Vasodilation and Sweating in Grafted Skin During Whole-Body Heating

Davis

Shibasaki

Low

et al. 2007

Journal of Burn Care & Research

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The aim of this investigation was to identify the consequences of skin grafting on cutaneous vasodilation and sweating in split-thickness grafted skin during indirect whole-body heating 5 to 9 months after surgery. In addition, thermoregulatory function was examined at donor skin sites on a separate day. Skin blood flow and sweat rate (SR) were assessed from both grafted (n = 14) or donor skin (n = 11) and compared with the respective adjacent control skin during indirect whole-body heating. Cutaneous vascular conductance (CVC) was calculated from the ratio of skin blood flow (arbitrary units; au) to mean arterial pressure. Whole-body heating significantly increased internal temperature (37.0 +/- 0.1 degrees C to 37.8 +/- 0.1 degrees C; P < .05). Cutaneous vasodilation (ie, the increase in CVC from baseline, deltaCVC) during whole-body heating was significantly attenuated in grafted skin (deltaCVC = 0.14 +/- 0.15 au/mm Hg) compared with adjacent control skin (deltaCVC = 0.84 +/- 0.11 au/mm Hg; P < .05). Increases in sweat rate (deltaSR) were also significantly lower in grafted skin (deltaSR = 0.08 +/- 0.08 mg/cm2/min) compared with adjacent control skin (deltaSR = 1.16 +/- 0.20 mg/ cm2/min; P < .05). Cutaneous vasodilation and sweating during heating were not significantly different between donor sites (deltaCVC = 0.71 +/- 0.19 au/mm Hg; deltaSR = 1.04 +/- 0.15 mg/cm2/min) and adjacent control skin (deltaCVC = 0.50 +/- 0.10 au/mm Hg; deltaSR = 0.83 +/- 0.17 mg/cm2/min). Greatly attenuated or absence of cutaneous vasodilation and sweating suggests impairment of thermoregulatory function in grafted skin, thereby, diminishing the contribution of this skin to overall temperature control during a heat stress.

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Development of microcirculation in full thickness autogenous skin grafts in mice

Cited by 58 publications

References 0 publications

Temporary Angiogenic Transformation of the Skin Graft Vasculature after Reperfusion

Temporary Angiogenic Transformation of the Skin Graft Vasculature after Reperfusion

In VivoStudies of Bone Grafts: The Possibility of Vascular Anastomoses in Healing Bone

Impaired Cutaneous Vasodilation and Sweating in Grafted Skin During Whole-Body Heating

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