Development of mouth dissolving tablets of clozapine using two different techniques

Abstract

Mouth dissolving tablets constitute an innovative dosage form that overcomes the problems of swallowing and provides a quick onset of action. In view of enhancing bioavailability an attempt has been made to study two different methods direct compression and sublimation in formulation of mouth dissolving tablets of clozapine. Total four formulations using various superdisintegrants and subliming agents were prepared. All prepared formulations were evaluated for physico-chemical parameters. The formulations exhibited good disintegration properties with total disintegration time in the range of 25 to 35 s. Comparative evaluation of two methods showed direct compression method is a better alternative to sublimation method as its formulations rapidly disintegrate in oral cavity. In vitro cumulative percentage drug release for formulations prepared by direct compression with explotab superdisintegrants shows 99.79 while sublimation method using camphor 93.58 release in 12 min. Kinetic studies indicated that all the formulations followed first order release with diffusion mechanism.

Utilization of biodiesel waste in the development of botanical-based floating tablet formulation against early stages of mosquitoes

“…Friability test finds out the physical strength of the tablets. Friability percentage should be less than 1 % for stable tablets [23]. The floating tablet friability was 0.7-0.9 %, which shows that the floating tablets are stable and can withstand in water for a longer duration.…”

Masalah dan Pengembangan Formulasi Obat untuk Bentuk Dosis Anak-Anak

“…al, 2013). Sifat dispersible ini akibat penambahan superdisintegran ke formulasi sediaan yang melepaskan obat dalam mulut dan meningkatkan bioavailabilitas (Masareddy et. al, 2008).…”

Oral dispersible system: A new approach in drug delivery system

“…These are tablets which get dispersed or disintegrate when gets in a contact with saliva with the release of active drug[ 15 16 ], providing maximum drug bioavailability as compared to conventional dosage form[ 17 ]. This dispersible property is given by the addition of superdisintegrants to the dosage form, that releases the drug in mouth increasing the bioavailability[ 18 ]. Three different methods for the addition of disintegrants are used, they are intra granular (within the granules), extra granular (addition after granulation) and combination of both processes[ 19 ].…”