Development of Mucoadhesive Nanoparticulate System of Ebastine for Nasal Drug Delivery

Khom, Tashi Chhojom; Yadav, Hemant Ks; Raizaday, Abhay; Manne, Navya; Kumar, Hemant; Kumar, Sankeerth N

doi:10.4314/tjpr.v13i7.2

Cited by 15 publications

(9 citation statements)

References 5 publications

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“…It has been shown that chitosan can be simply processed into various dosage forms, including gels, sponges, membranes, beads, and scaffolds. On the other side, the viscosity of chitosan and its interaction between the positively charged amino groups and the negatively charged residues on the mucosal surface, renders it its mucoadhesive features (Khom et al 2014). These functional groups can be chemically modified for creating carrier systems with particular properties which are suitable for the nasal, oral, ocular, and transdermal administrations (Hamidi et al 2008;Amidi et al 2010).…”

Section: Chitosan-based Hydrogel Nanoparticlesmentioning

confidence: 98%

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

et al. 2016

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Over the past few years, nasal drug delivery has attracted more and more attentions, and been recognized as the most promising alternative route for the systemic medication of drugs limited to intravenous administration. Many experiments in animal models have shown that nanoscale carriers have the ability to enhance the nasal delivery of peptide/protein drugs and vaccines compared to the conventional drug solution formulations. However, the rapid mucociliary clearance of the drug-loaded nanoparticles can cause a reduction in bioavailability percentage after intranasal administration. Thus, research efforts have considerably been directed towards the development of hydrogel nanosystems which have mucoadhesive properties in order to maximize the residence time, and hence increase the period of contact with the nasal mucosa and enhance the drug absorption. It is most certain that the high viscosity of hydrogel-based nanosystems can efficiently offer this mucoadhesive property. This update review discusses the possible benefits of using hydrogel polymer-based nanoparticles and hydrogel nanocomposites for drug/vaccine delivery through the intranasal administration.

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Section: Chitosan-based Hydrogel Nanoparticlesmentioning

confidence: 98%

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

et al. 2016

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“…Microparticles were allowed to swell for 12 h. The excess surface adhered liquid drops were removed by blotting with soft tissue papers and the swollen microparticles were weighed on weighing balance. [17,22,23] Weight of swollen microparticlesWeight of dry microparticles % swelling study = ×100 Weight of dry microparticles (2)…”

Section: Swelling Studymentioning

confidence: 99%

“…this study is conducted for detection of melting point and heat of fusion to evaluate the crystalline nature of drugs. [22,23,27] …”

Section: Differential Scanning Calorimetric (Dsc)mentioning

confidence: 99%

“…The samples were mounted on a sample holder and XRD patterns were recorded in the range of 5-50° at the speed of 5°/min. [21,22] …”

Section: X-ray Diffraction (Xrd) Studiesmentioning

confidence: 99%

“…Sialic acid carries a net negative charge and providing strong electrostatic interaction between mucin and chitosan. [22] In vitro drug release study…”

Section: Mucoadhesion Studymentioning

confidence: 99%

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Sakhare¹

2017

AJP

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Objectives: The purpose of present research work was to develop mucoadhesive microparticles of Zaleplon for nasal delivery with the aim to avoid hepatic first-pass metabolism, improve therapeutic efficacy and enhance residence time in the treatment of insomnia. Materials and Methods: Chitosan-based microparticles were prepared by the coacervation method by varying the drug:polymer ratio. The microparticles were evaluated for particle size and shape and surface morphology by scanning electron microscopy, drug content, drug entrapment efficiency, swelling study, in vitro mucoadhesion, differential scanning calorimetric (DSC), X-ray diffraction (XRD), Fourier transform infrared (FTIR), in vitro drug release study, and ex vivo drug permeation. Results: Zaleplon microparticles showed irregular-shaped particles and particle size was found to be in the range of 4.97-10.6 μm, which is favorable for intranasal absorption. The prepared microparticles exhibited a good swelling index. The percentage drug content and entrapment efficiency was found to be in the range between 36.36% -80% and 37.65% -52.88%, respectively. In vitro mucoadhesion was performed by adhesion number using goat nasal mucosa and was observed in a range from 43.33 ± 4.409 to 75 ± 2.886%. It was observed that polymer concentration enhancement led to increased mucoadhesive strength. The results of DSC and XRD studies revealed the molecular amorphous dispersion of Zaleplon into the chitosan microparticles. IR spectra of Zaleplon along with excipient showed no interaction between Zaleplon and excipients. In vitro drug release from all the formulations was biphasic, being characterized by a slight "burst" followed by slow release. At the end of 12 h, F6 (1:6) showed drug release of 81.66 ± 1.545%, indicating sustained release. The permeation data of formulation from goat nasal mucosa was found near to that obtained with dialysis membrane in vitro. Conclusion: According to the obtained results, Zaleplon loaded chitosan microparticles prepared by coacervation method proved to be capable of sustained release and could be used through nasal route as an alternative to oral administration.

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Chitin and Chitosan in Drug Delivery

Parhi

2019

Sustainable Agriculture Reviews

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Development of Mucoadhesive Nanoparticulate System of Ebastine for Nasal Drug Delivery

Cited by 15 publications

References 5 publications

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

Hydrogel nanoparticles and nanocomposites for nasal drug/vaccine delivery

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Chitin and Chitosan in Drug Delivery

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