Development of Nonalcoholic Hepatopathy: Contributions of Oxidative Stress and Advanced Glycation End Products

Santos, Juliana Célia de Farias; Valentim, Iara Barros; Araújo, Orlando Roberto Pimentel de; Ataíde, Terezinha da Rocha; Goulart, Marília Oliveira Fonseca

doi:10.3390/ijms141019846

Cited by 65 publications

(53 citation statements)

References 59 publications

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“…Presence of AGEs has been shown in the liver of patients with non-alcoholic steatohepatitis using immunohistochemical methods, and serum AGE levels were found related with the severity of hepatic disorder (18)(19)(20).…”

Section: Hepatic Diseasesmentioning

confidence: 98%

Dietary glycotoxins and infant formulas

Kutlu

2016

Turk Pediatri Ars

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Advanced glycation end products constitute a complex group of compounds derived from the nonenzymatic glycation of proteins, lipids, and nucleic acids formed endogenously, but also from exogenous supplies such as tobacco smoking (glycotoxins). Accumulating evidence underlies the beneficial effect of the dietary restriction of glycotoxins in animal studies and also in patients with diabetic complications and metabolic diseases. Composition of infant formulas and their processing methods render an extraordinary favorable milieu for the formation of glycotoxins, and the content of glycotoxins in infant formula exceeds that of breast milk by hundred folds. Data from a limited number of short-term small studies in healthy infants do not provide direct evidence of acute negative health effects of glycotoxins in early infancy. However, the effects in sensitive groups on the state of future health in adulthood remain unclear. (Turk Pediatri Ars 2016; 51: 179-85)

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Section: Hepatic Diseasesmentioning

confidence: 98%

Dietary glycotoxins and infant formulas

Kutlu

2016

Turk Pediatri Ars

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“…Повреждение (сшивки) матричных белков в почечной ткани; снижение скорости клубочковой фильтрации; нефротоксичность (на примере лабора-торных животных) [24][25][26] Заболевания печени Биохимические изменения в крови; жировое перерождение и цирроз печени (на примере лабораторных животных) [27][28][29] …”

Section: заболевания почекunclassified

Maillard Reactions – An Important Factor of the Safety and Quality of Infant Formula

Николаевич¹,

Колин²,

Николаевна³

2018

Ross. vestn. perinatol. pediatr.

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The physicochemical properties of infant adapted milk formulae that affect their tolerability and effectiveness depend on the composition and quality of the raw ingredients, the production process, the storage conditions and the quality control of the finished products. The technology of manufacturing a powdered infant formula includes a variety of methodsfor processing componentsthat make up its composition, including raw milk. This processing is accompanied by a noticeable change in a number of physical, chemical and biological properties of the individual components of milk, their loss, the formation of fundamentally new chemical compounds. The most frequent reactions observed during the heat treatment of milk include the formation of bonds between reactive carbonyl groups of the sugar and the amino groups of amino acids, followed by the appearance of a large number of low- and high-molecular compounds, the so-called Maillard Reaction Products(MRP). The study of MRP in recent years hasincreasingly attracted the attention of medical practitioners because of the discovery of these compounds in infant formula and their potential danger to children’s health. This review provides evidence that powdered infant adapted formulae produced with an original technology based on whole goat milk with a native ratio of the main groups of milk proteins(whey – 20% and casein – 80%) have a minimum potential for unwanted effects associated with MRP.

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“…It is well known that oxidative species favours the glycoxidation reaction of proteins in presence of reducing sugars, thus resulting in AGEs accumulation. In turn, AGEs exert a prooxidant effect compromising antioxidant enzymes activity and mitochondrial functions, thus creating a vicious cycle [81]. In this regard, a very recent study evidenced that fructose feeding activates in rats the so-called AROS axis, featured by the consecutive enhancement in plasma AGEs level -tissue RAGE activation -mitochondrial ROS production, with subsequent intracellular AGEs formation [82].…”

Section: Interference On Mitochondrial Function and Oxidative Stressmentioning

confidence: 99%

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

Aragno¹,

Mastrocola²

2017

Preprint

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Abstract.The rapid increase in metabolic diseases occurred in the last three decades in both industrialized and developing countries has been related to the rise in sugar-added foods and sweetened beveragesconsumption. An emerging topic in the pathogenesis of metabolic diseases related to modern nutrition is the role of Advanced Glycation Endproducts (AGEs). AGEs can be ingested with high temperature processed foods, but also endogenously formed as consequence of a high dietary sugars intake. Animal models of high sugars consumption, in particular fructose, have reported AGEs accumulation in different tissues in association with peripheral insulin resistance and lipid metabolism alterations. The in vitro observation that fructose is one of the most rapid and effective glycating agent when compared to other sugars has prompted the investigation of the in vivo fructose-induced glycation. In particular, the widespread employment of fructose as sweetener has been ascribed by many experimental and observational studies for the enhancement of lipogenesis and intracellular lipid deposition. Indeed, diet-derived AGEs have been demonstrated to interfere with many cell functions such as lipid synthesis, inflammation, antioxidant defences, and mitochondrial metabolism. Moreover, emerging evidences also in humans suggest that this impact of dietary AGEs on different signalling pathways can contribute to the onset of organ damage in liver, skeletal and cardiac muscle, and brain, affecting not only metabolic control, but global health.Indeed, the here reviewed most recent reports on the effects of high sugars consumption and dietderived AGEs on human health suggest the need to limit the dietary sources of AGEs, including added sugars, to prevent the development of metabolic diseases and related comorbidities.

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Development of Nonalcoholic Hepatopathy: Contributions of Oxidative Stress and Advanced Glycation End Products

Cited by 65 publications

References 59 publications

Dietary glycotoxins and infant formulas

Dietary glycotoxins and infant formulas

Maillard Reactions – An Important Factor of the Safety and Quality of Infant Formula

Dietary Sugars and Endogenous Formation of Advanced Glycation Endproducts: Emerging Mechanisms of Disease

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