Development of Novel Microemulsion-Based Topical Formulations of Acyclovir for the Treatment of Cutaneous Herpetic Infections

Shishu,; Rajan, Sunita; Kamalpreet,

doi:10.1208/s12249-009-9242-1

Cited by 53 publications

(29 citation statements)

References 14 publications

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“…MEs are involved in formulating many antiviral drugs in order to improve their permeability and efficacy. An ME formula composed of isopropyl myristate, captex 355, labrafac, Tween 20, Span 20, water, and dimethylsulfoxide, was involved in encapsulating an antiviral drug, acyclovir (17). It was found that this formula improved the drug penetration and, hence, its efficiency against HSV-1 infection.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Biocompatible Microemulsions Against Aspergillus niger and Herpes Simplex Virus Type 2

Alkhatib¹,

Aly²,

Rahbeni³

et al. 2016

Jundishapur J Microbiol

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Background: Microemulsions (MEs), which consist of oil, water, surfactants, and cosurfactants, have recently generated considerable interest as antimicrobial agents. Objectives: To determine the antifungal and antiviral activities of three ME formulations (MEa, MEb, and MEc) that differ in their hydrophilicity. Methods:The ME formulas were produced by mixing different fractions of Tween 80, Span 20, ethanol, oil, isopropyl myristate, and distilled water. The antifungal activity of the ME formulas against Aspergillus niger, A. flavus, Bacillus, Candida albicans, and C. glabrata were determined by the solid medium diffusion cytotoxicity test against the mitochondria, measuring the minimum inhibitory concentration, dry biomass, and leakage of potassium, and characterizing the cell morphology. The antiviral activities of the ME formulas against the herpes simplex virus type 2 (HSV-2) were determined using the cytopathic effect assay. Results: Significant antimicrobial activities were recorded against A. niger and herpes simplex virus type 2 (HSV-2) when treated

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Section: Discussionmentioning

confidence: 99%

Antimicrobial Activity of Biocompatible Microemulsions Against Aspergillus niger and Herpes Simplex Virus Type 2

Alkhatib¹,

Aly²,

Rahbeni³

et al. 2016

Jundishapur J Microbiol

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“…Topical antiherpes formulations received increased attention in drug development, according to their advantages, over oral and systemic administration. Several topical preparations of ACV, penciclovir, foscarnet, as well as docosanol, are in current clinical use and research (3,(6)(7)(8)(9).…”

Section: Introductionmentioning

confidence: 99%

Microemulsion-Based Oxyresveratrol for Topical Treatment of Herpes Simplex Virus (HSV) Infection: Physicochemical Properties and Efficacy in Cutaneous HSV-1 Infection in Mice

et al. 2012

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Abstract. The physicochemical properties of the optimized microemulsion and the permeating ability of oxyresveratrol in microemulsion were evaluated, and the efficacy of oxyresveratrol microemulsion in cutaneous herpes simplex virus type 1 (HSV-1) infection in mice was examined. The optimized microemulsion was composed of 10% w/w of isopropyl myristate, 35% w/w of Tween 80, 35% w/w of isopropyl alcohol, and 20% w/w of water. The mean particle diameter was 9.67±0.58 nm, and the solubility of oxyresveratrol in the microemulsion was 196.34±0.80 mg/ml. After accelerated and long-term stability testing, the microemulsion base and oxyresveratrol-loaded microemulsion were stable. The cumulative amount of oxyresveratrol permeating through shed snake skin from microemulsion at 6 h was 93.04 times compared to that of oxyresveratrol from Vaseline, determined at 20% w/w concentration. In cutaneous HSV-1 infection in mice, oxyresveratrol microemulsion at 20%, 25%, and 30% w/w, topically applied five times daily for 7 days after infection, was significantly effective in delaying the development of skin lesions and protecting from death (p<0.05) compared with the untreated control. Oxyresveratrol microemulsion at 25% and 30% w/w was significantly more effective than that of 30% w/w of oxyresveratrol in Vaseline (p<0.05) and was as effective as 5% w/w of acyclovir cream, topically applied five times daily (p>0.05). These results demonstrated that topical oxyresveratrol microemulsion at 20-30% w/w was suitable for cutaneous HSV-1 mouse infection.

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“…[107] In the same way, a novel microemulsion based topical formulation of ACV resulted in total inhibition of herpetic skin lesions. [108] An liquid-in-oil microemulsion system containing 3:2 ratio of tween 80 and span 20 as nonionic surfactants and dimethylimidazolium dimetyhylphosphate as pseudophase was identified to show excellent solubility and skin permeation enhancing effect with Yucatan micropig procine skin. A low cytotoxicity effect was reported for the carriers using reconstructed human epidermal model LabCyteTM EPI-MODEL12.…”

Section: Novel Spontaneous Emulsification Solvent Diffusion Methodsmentioning

confidence: 99%

Drug delivery approaches of an antiviral drug: A comprehensive review

Durai¹

2015

Asian J Pharm

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T he guanine derivative antiviral drug acyclovir (ACV) is one of the oldest molecules laying successful market until date, being commercially available in various dosage forms for oral, topical and parenteral administrations. Clinical application of this drug is superior to new antiviral agents due to its potential values such as suppression of recurrence, safety profile, minimal drug interactions, and being inexpensive. ACV is slightly water-soluble, less permeable and poorly bioavailable, yet more potential antiviral molecule, the physicochemical modifications and novel dosage form approaches resulted with more than 100 research works within a decade. The survey of literature showed enormous reports on ACV formulation development, which includes modified tablets, particulate drug delivery, vesicular drug delivery, polymeric nanoparticles, bioadhesive systems, floating dosage forms, in situ gelling systems, transdermal delivery, implantable systems, emulsified dosage forms, polymeric films/patches, etc. As the drug could be administered via multiple routes for effective site targeted action at various doses, and attracted the attention of many researches, the review of the current approaches for the delivery of ACV could be more beneficial for the new scientists. This paper is a review of recent researches highlighting the development of newer techniques and novel dosage forms of ACV for better therapeutic efficacy, which were aimed at enhancing its solubility, permeability and bioavailability.Durai: Recent formulation designs of acyclovir How to cite this article: Durai RD. Drug delivery approaches of an antiviral drug: A comprehensive review. Asian J Pharm 2015;9:1-12.

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Development of Novel Microemulsion-Based Topical Formulations of Acyclovir for the Treatment of Cutaneous Herpetic Infections

Cited by 53 publications

References 14 publications

Antimicrobial Activity of Biocompatible Microemulsions Against Aspergillus niger and Herpes Simplex Virus Type 2

Antimicrobial Activity of Biocompatible Microemulsions Against Aspergillus niger and Herpes Simplex Virus Type 2

Microemulsion-Based Oxyresveratrol for Topical Treatment of Herpes Simplex Virus (HSV) Infection: Physicochemical Properties and Efficacy in Cutaneous HSV-1 Infection in Mice

Drug delivery approaches of an antiviral drug: A comprehensive review

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