Antimicrobial Activity of Biocompatible Microemulsions Against Aspergillus niger and Herpes Simplex Virus Type 2

Alkhatib, Mayson H.; Aly, Magda M.; Rahbeni, Rajaa A; Balamash, Khadijah S.

doi:10.5812/jjm.37437

Cited by 8 publications

(8 citation statements)

References 14 publications

(18 reference statements)

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“…Limit of detection antimicrobial activity [8] and specific activity against Herpes Simplex virus [9], and other mouthwash formulations containing 0.07 % CPC have been reported to reduce infectivity of seasonal coronaviruses by 3-4-log10 [4]. In our study, SARS-CoV2 was even more sensitive to the CPCcontaining mouthwashes than in these previous reports using hCoV-229E; this may reflect the cumulative activity of additional components in these formulations.…”

Section: Product Name Active Ingredientssupporting

confidence: 39%

Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro

Statkute

Rubina

O'Donnell

et al. 2020

Preprint

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The ability of widely-available mouthwashes to inactivate SARS-CoV-2 in vitro was tested using a protocol capable of detecting a 5-log10 reduction in infectivity, under conditions mimicking the naso/oropharynx. During a 30 second exposure, two rinses containing cetylpyridinium-chloride and a third with ethanol/ethyl lauroyl arginate eliminated live virus to EN14476 standards (>4-log10 reduction), while others with ethanol/essential oils and povidone-iodine (PVP-I) eliminated virus by 2-3-log10. Chlorhexidine or ethanol alone displayed little or no ability to inactivate virus. Studies are warranted to determine whether these formulations can inactivate virus in the human oropharynx in vivo, and whether this might impact transmission risk.

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Section: Product Name Active Ingredientssupporting

confidence: 39%

Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro

Statkute

Rubina

O'Donnell

et al. 2020

Preprint

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“…These effects were reported after a very short incubation period, ranging from 30 secs to 2 min [ 119 ]. Accordingly, a microemulsion formulated from different fractions of Tween-80, Span-20, ethanol, oil, isopropyl myristate (IPM), and distilled water, dramatically limited the infectivity of HSV-2 in vitro [ 120 ].…”

Section: Anti-viral Propertiesmentioning

confidence: 99%

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

et al. 2020

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Surface active agents (SAAs) are molecules with the capacity to adsorb to solid surfaces and/or fluid interfaces, a property that allows them to act as multifunctional ingredients (e.g., wetting and dispersion agents, emulsifiers, foaming and anti-foaming agents, lubricants, etc.) in a widerange of the consumer products of various industrial sectors (e.g., pharmaceuticals, cosmetics, personal care, detergents, food, etc.). Given their widespread utilization, there is a continuously growing interest to explore their role in consumer products (relevant to promoting human health) and how such information can be utilized in order to synthesize better chemical derivatives. In this review article, weaimed to provide updated information on synthetic and biological (biosurfactants) SAAs and their health-promoting properties (e.g., anti-microbial, anti-oxidant, anti-viral, anti-inflammatory, anti-cancer and anti-aging) in an attempt to better define some of the underlying mechanism(s) by which they exert such properties.

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“…Morphology of HSV-1 observed by transmission electron microscopy was found to damage and shed the envelope of HSV-1 (Wang et al 2015). The antiviral activities against HSV-2 estimated using the cytopathic effect assay showed also microemulsions with mean nanodroplet diameter of 4.7 ± 1.22 nm consisting of oil, water, surfactants, and cosurfactants that were able to destroy the HSV-2 virus at a 200-fold dilution in Dulbecco's modified eagle medium (Alkhatib et al 2016). Pentyl gallate nanoemulsions (particle sizes of 124.8-143.7 nm; zeta potential ranging from −50.1 to −66.1 mV) demonstrated anti-HSV-1 activity and the drug reached deeper into the dermis more efficiently from the nanoemulsion as free drug, suggesting that nanoemulsions have potential to be used in topically delivering pentyl gallate in the treatment of human herpes labialis infection affecting primarily the lip (Kelmann et al 2016).…”

Section: Herpes Simplex Virusmentioning

confidence: 98%

Nanoformulations: A Valuable Tool in the Therapy of Viral Diseases Attacking Humans and Animals

Jampílek

Kráľová

2019

Nanotheranostics

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Various viruses can be considered as one of the most frequent causes of human diseases, from mild illnesses to really serious sicknesses that end fatally. Numerous viruses are also pathogenic to animals and plants, and many of them, mutating, become pathogenic also to humans. Several cases of affecting humans by originally animal viruses have been confirmed. Viral infections cause significant morbidity and mortality in humans, the increase of which is caused by general immunosuppression of the world population, changes in climate, and overall globalization. In spite of the fact that the pharmaceutical industry pays great attention to human viral infections, many of clinically used antivirals demonstrate also increased toxicity against human cells, limited bioavailability, and thus, not entirely suitable therapeutic profile. In addition, due to resistance, a combination of antivirals is needed for life-threatening infections. Thus, the development of new antiviral agents is of great importance for the control of virus spread. On the other hand, the discovery and development of structurally new antivirals represent risks. Therefore, another strategy is being developed, namely the reformulation of existing antivirals into nanoformulations and investigation of various metal and metalloid nanoparticles with respect to their diagnostic, prophylactic, and therapeutic antiviral applications. This chapter is focused on nanoscale materials/formulations with the potential to be used for the treatment or inhibition of the spread of viral diseases caused by human immunodeficiency virus, influenza A viruses (subtypes H3N2 and H1N1), avian influenza and swine influenza viruses, respiratory syncytial virus, herpes simplex virus, hepatitis B and C viruses, Ebola and Marburg viruses, Newcastle disease virus, dengue and Zika viruses, and pseudorabies virus. Effective antiviral long-lasting and target-selective nanoformulations developed for oral, intravenous, intramuscular, intranasal, intrarectal, intravaginal, and intradermal applications are discussed.

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Antimicrobial Activity of Biocompatible Microemulsions Against Aspergillus niger and Herpes Simplex Virus Type 2

Cited by 8 publications

References 14 publications

Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro

Brief Report: The Virucidal Efficacy of Oral Rinse Components Against SARS-CoV-2 In Vitro

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

Nanoformulations: A Valuable Tool in the Therapy of Viral Diseases Attacking Humans and Animals

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