Development of the Human Pancreas From Foregut to Endocrine Commitment

Jennings, Rachel; Berry, Andrew; Kirkwood-Wilson, R.; Roberts, Neil; Hearn, Tom; Salisbury, Rachel J.; Blaylock, Jennifer; Hanley, Karen Piper; Hanley, Neil A.

doi:10.2337/db12-1479

Cited by 260 publications

(447 citation statements)

References 43 publications

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“…These data are supported by reports that the expression of Ngn3 and Hes1 is mutually exclusive in the developing pancreas (27,35), as is the expression of Sox9 and Ngn3 at the endocrine progenitor stage (46,(103)(104)(105). Furthermore, Sox9 occupancy regions on the Ngn3 gene promoter have been identified (104,106).…”

Section: Nsc Biology Suggests the Involvement Of Noncanonical Signalisupporting

confidence: 72%

Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology

et al. 2016

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Loss of insulin-producing pancreatic islet β-cells is a hallmark of type 1 diabetes. Several experimental paradigms demonstrate that these cells can, in principle, be regenerated from multiple endogenous sources using signaling pathways that are also used during pancreas development. A thorough understanding of these pathways will provide improved opportunities for therapeutic intervention. It is now appreciated that signaling pathways should not be seen as “on” or “off” but that the degree of activity may result in wildly different cellular outcomes. In addition to the degree of operation of a signaling pathway, noncanonical branches also play important roles. Thus, a pathway, once considered as “off” or “low” may actually be highly operational but may be using noncanonical branches. Such branches are only now revealing themselves as new tools to assay them are being generated. A formidable source of noncanonical signal transduction concepts is neural stem cells because these cells appear to have acquired unusual signaling interpretations to allow them to maintain their unique dual properties (self-renewal and multipotency). We discuss how such findings from the neural field can provide a blueprint for the identification of new molecular mechanisms regulating pancreatic biology, with a focus on Notch, Hes/Hey, and hedgehog pathways.

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Section: Nsc Biology Suggests the Involvement Of Noncanonical Signalisupporting

confidence: 72%

Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology

et al. 2016

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“…It has been shown that the development of the dorsal pancreas bud from the foregut endoderm is affected by the adjacent notochord (35,36), as well as the signals coming from the dorsal aorta and other vessels (37,38). In human embryos, the dorsal foregut epithelium, which is a single line in the 4-12 somite period, was found to be close to the notochord (39). In mice and chicks, it has been shown that the dorsal aorta induces pancreatic development, particularly the insulin expression of the dorsal pancreatic endoderm (37).…”

Section: Pancreas Developmentmentioning

confidence: 99%

“…The border of the pancreatic areas and the formation and growth of the pancreatic bud are similar within the ventral and dorsal foregut in both the species. Following these events, separate cell lines are seen to become different (39,42).…”

Section: Pancreas Developmentmentioning

confidence: 99%

Development of Liver and Pancreas

Eşrefoğlu¹,

Taşlıdere²,

Çetin³

2016

Bezmialem Science

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The parenchyma of the liver and pancreas is derived from the endoderm, whereas the stroma is derived from the mesoderm. Both of them are derived from the endoderm of the foregut as the esophagus, stomach, and a part of duodenum. At the 3 rd -4 th of development, the liver, gallbladder and bile ducts become diverticulum hepaticum that is derived from the caudal portion of the foregut. There were inductive effects of septum transversum and cardiac mesoderm for the development of liver diverticulum. The pancreas arise from the endoderm of the foregut. The pancreas is derived from the fusion of the ventral and dorsal pancreas bulbs, which arise from the endoderm of the duodenum. The inductive effects of the notochord and dorsal aorta play a role in the development of the pancreas. In this manuscript, we attempted to review the morphological and functional development of the liver and pancreas with the aid of pictures obtained from various stages of prenatal and postnatal development in the organs of rats.

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“…It is well known that once the mesenchymal cells proliferate between aortic ECs and the foregut endoderm, the aorta is pulled out from the subjacent gut (compare Figure 2 with Figure 3) [20,55] . This fact implies that the subjacent foregut starts receiving signals from the mesenchyme and that a gradient can be formed with diluted signals from aortic ECs.…”

Section: Signals From Pancreatic Mesenchyme Toward Exocrine Pancreasmentioning

confidence: 99%

“…The pancreas originates from ventral and dorsal buds formed in the foregut at 8.5 d post-coitum (d.p.c) of gestation in mice and Carnegie stage 12 (CS12) in humans [54][55][56] . The cells that composed these buds express transcription factors such as PDX-1 which is a key regulator of pancreas development [57][58][59] .…”

Section: Endothelium Role In the Pancreatic Nichementioning

confidence: 99%

Endothelium-derived essential signals involved in pancreas organogenesis

Talavera-Adame

Dafoe

2015

WJEM

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Endothelial cells (ECs) are essential for pancreas differentiation, endocrine specification, and endocrine function. They are also involved in the physiopathology of type 1 and type 2 diabetes. During embryogenesis, aortic ECs provide specific factors that maintain the expression of key genes for pancreas development such as pancreatic and duodenal homeobox-1. Other unknown factors are also important for pancreatic endocrine specification and formation of insulin-producing beta cells. Endocrine precursors proliferate interspersed with ductal cells and exocrine precursors and, at some point of development, these endocrine precursors migrate to pancreatic mesenchyme and start forming the islets of Langerhans. By the end of the gestation and close to birth, these islets contain immature beta cells with the capacity to express vascular endothelial growth factor and therefore to recruit ECs from the surrounding microenvironment. ECs in turn produce factors that are essential to maintain insulin secretion in pancreatic beta cells. Once assembled, a cross talk between endocrine cells and ECs maintain the integrity of islets toward an adequate function during the whole life of the adult individual. This review will focus in the EC role in the differentiation and maturation of pancreatic beta cells during embryogenesis as well as the current knowledge about the involvement of endothelium to derive pancreatic beta cells in vitro from mouse or human pluripotent stem cells.

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Development of the Human Pancreas From Foregut to Endocrine Commitment

Cited by 260 publications

References 43 publications

Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology

Endocrine Pancreas Development and Regeneration: Noncanonical Ideas From Neural Stem Cell Biology

Development of Liver and Pancreas

Endothelium-derived essential signals involved in pancreas organogenesis

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