Development of the Synthesis of 2,4-Di(α-methoxyethyl)- deuteroporphyrin IX Ytterbium Complex Dipotassium Salt

Shchelkunova, Anastasiya E.; Boltukhina, Ekaterina V.; Rumyantseva, V. D.; Шилов, И. П.; Karakotov, S. D.

doi:10.6060/mhc190658s

Cited by 3 publications

References 7 publications

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Theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy in the absorption band of porphyrin

Шилов¹,

Горшкова²,

Иванов³

et al. 2022

Quantum Electron.

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We report the results of developing a technique for theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy (PDT) in the absorption band of porphyrin. It is shown that the therapeutic effect is achieved exclusively due to PDT, without the participation of the hyperthermia process, which occurs at temperatures above 42 °C. The Fluroscan gel [based on the dipotassium salt of the ytterbium complex of 2,4-di-(a-methoxyethyl)deuteroporphyrin IX (Yb-DMDP)] is used as a preparation for theranostics. The main photophysical properties and possible mechanisms of accumulation of nanosized low-toxic photosensitisers based on this compound are studied. It is shown that the Yb-DMDP compound in a DMSO solution (30% aqueous DMSO) enhances photophysical characteristics (luminescence lifetime 5-10 ms, luminescence quantum yield up to 1%, extinction coefficient ~1.96 × 105 M-1 cm-1 at a wavelength of 398 nm). Experimental animals are used to test the proposed technique for theranostics of tumours using the Fluroscan gel and a fibre-optic laser fluorimeter.

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Theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy in the absorption band of porphyrin

Шилов¹,

Горшкова²,

Иванов³

et al. 2022

Quantum Electron.

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Ytterbium porphyrins complexes for NIR-luminescent diagnostics and magneto-luminescent theranostics of tumours

Шилов

Иванов

Rumyantseva

et al. 2020

J. Phys.: Conf. Ser.

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Promising ytterbium porphyrins complexes (YbPC) and nanocomposites on its base for NIR-luminescent diagnostics and magneto-luminescent cancer theranostics are presented. The considered complexes are very promising substances for the cancer luminescent diagnostics (LD) in the NIR spectrum region (800–1100 nm). For LD of malignant tumors of the skin and mucous membranes, a pharmaceutical composition of the «Fluroscan» type was developed. It has been established that YbPC can also be used as one of the main components of the nanocomposites created for cancer theranostics, including magneto-luminescent theranostics (MLT). For the purposes of MLT, a 3-component nanocomposite was developed, consisting of a polymer matrix (Lexan type), a diagnostic substance based on the ytterbium complex of hematoporphyrin IX tetramethyl ester, and a therapeutic FeOx component.

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Наноразмерные Пленочные Элементы На Основе Тетрафенилпорфирина Для Обнаружения Катионов Европия В Воде Флуоресцентным Методом

Лобанов

Грузнова

Рубцова

2020

Химическая Безопасность / Chemical Safety Science

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Показано, что мономолекулярный слой тетрафенилпорфирина в смеси со стеариновой кислотой, перенесенный на модифицированные кварцевые пластины, проявляет флуоресцентные свойства, чувствительные к присутствию катионов европия(III) в водных средах. Предложен сенсорный элемент для количественного определения европия в воде и определены его рабочие параметры. Monomolecular layer of tetraphenylporphyrin mixed with stearic acid transferred onto modified quartz plates is shown to exhibit fluorescent properties sensitive to the presence of europium(III) cations in aqueous media. A principal possibility of producing a sensor element for quantitative determination of europium in water is proposed, and its performance parameters are determined.

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Development of the Synthesis of 2,4-Di(α-methoxyethyl)- deuteroporphyrin IX Ytterbium Complex Dipotassium Salt

Cited by 3 publications

References 7 publications

Theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy in the absorption band of porphyrin

Theranostics of skin neoplasms based on luminescence diagnostics in combination with photodynamic therapy in the absorption band of porphyrin

Ytterbium porphyrins complexes for NIR-luminescent diagnostics and magneto-luminescent theranostics of tumours

Наноразмерные Пленочные Элементы На Основе Тетрафенилпорфирина Для Обнаружения Катионов Европия В Воде Флуоресцентным Методом

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