Development of visual acuity in infant monkeys (Macaca nemestrina) during the early postnatal weeks

Teller, Davida Y.; Regal, David M.; Videen, Tom O.; Pulos, Elizabeth

doi:10.1016/0042-6989(78)90203-1

Cited by 81 publications

(47 citation statements)

References 18 publications

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“…DR results in profound deficits in the development of visual acuity and RF properties of visual cortical neurons, and a prolongation of critical period for OD plasticity (2,(7)(8)(9)(10). It is possible, in this regard, that the effects of DR are mediated by multiple and parallel molecular and cellular mechanisms.…”

Section: Discussionmentioning

confidence: 99%

“…Visual deprivation such as dark rearing (DR) from birth delays the normal development of the visual cortex (5,6) and can impair visual function permanently. For example, in dark-reared adult animals, visual acuity remains low and the receptive field (RF) sizes of visual cortical neurons remain large (2,7,8). In addition, in darkreared animals, OD of visual cortex remains sensitive to monocular deprivation (MD) beyond the critical period defined in light-reared animals (9,10).…”

mentioning

confidence: 99%

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Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF

Gianfranceschi

Siciliano

Walls

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

171

147

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Visual deprivation such as dark rearing (DR) prolongs the critical period for ocular dominance plasticity and retards the maturation of ␥-aminobutyric acid (GABA)ergic inhibition in visual cortex. The molecular signals that mediate the effects of DR on the development of visual cortex are not well defined. To test the role of brain-derived neurotrophic factor (BDNF), we examined the effects of DR in transgenic mice in which BDNF expression in visual cortex was uncoupled from visual experience and remained elevated during DR. In dark-reared transgenic mice, visual acuity, receptive field size of visual cortical neurons, critical period for ocular dominance plasticity, and intracortical inhibition were indistinguishable from those observed in light-reared mice. Therefore, BDNF overexpression is sufficient for the development of aspects of visual cortex in the absence of visual experience. These results suggest that reduced BDNF expression contributes to retarded maturation of GABAergic inhibition and delayed development of visual cortex during visual deprivation.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF

Gianfranceschi

Siciliano

Walls

et al. 2003

Proc. Natl. Acad. Sci. U.S.A.

171

147

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“…In kittens (Mitchell, Giffin, Wilkinson, Anderson & Smith, 1976), infant monkeys (Teller, Regal, Videen & Pulos, 1978;Teller & Boothe, 1979) and human babies (Teller, Morse, Borton & Regal, 1974;Atkinson, Braddick & Braddick, 1974;Dobson & Teller, 1978) there is a substantial and surprisingly slow improvement in visual acuity, measured behaviourally, during the first few months or more of life. New-born babies, both human and monkey, have grating resolution acuities of only about 0.5-1 cycles/deg (cycles per degree of visual angle), around 50-100 times lower than in adults (Teller et al 1974.…”

Section: Introductionmentioning

confidence: 99%

Organization and post‐natal development of the monkey's lateral geniculate nucleus.

Blakemore¹,

Vital‐Durand²

1986

The Journal of Physiology

217

103

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SUMMARY1. We have studied the properties of neurones in the lateral geniculate nucleus (l.g.n.) of Old World monkeys, both in mature animals and throughout post-natal development.2. Cells were classified as X (linear) or Y (non-linear) on the basis of their responses to contrast-reversing achromatic gratings ('null position test'). In older animals virtually all parvocellular neurones and the majority of magnocellular units were X cells; only about 15 % of magnocellular neurones displayed highly non-linear spatial summation, with no 'null position', typical of Y cells.

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“…These methods, however, are not useful for studying very young infants, with the notable exception of the forced-choice preferential looking paradigm (e.g., Teller, Regal, Videen, & Pulos, 1978). Although preference studies can provide valuable information, they demand that questions be answerable in terms of a discrimination.…”

mentioning

confidence: 99%

Monitoring visual activity in infant rhesus monkeys: Method and calibration

Mendelson

Haith

Goldman‐Rakic

1981

Behavior Research Methods & Instrumentation

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Development of visual acuity in infant monkeys (Macaca nemestrina) during the early postnatal weeks

Cited by 81 publications

References 18 publications

Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF

Visual cortex is rescued from the effects of dark rearing by overexpression of BDNF

Organization and post‐natal development of the monkey's lateral geniculate nucleus.

Monitoring visual activity in infant rhesus monkeys: Method and calibration

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