Development of wireless neural interface system

Im, Changkyun; Koh, Chin Su; Park, Hae Yong; Shin, Jaewoo; Jun, S.; Jung, Hyun Ho; Ahn, Jae Mok; Chang, Jin Woo; Kim, Yong Joong; Shin, Hyung Cheul

doi:10.1007/s13534-016-0232-4

Cited by 4 publications

(4 citation statements)

References 33 publications

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“…This device has a wide programmable gain range compared to other examined devices [50, 52, 53] (having fixed or limited gain variability) that offers the following advantage. In LFPs, the magnitude of the potentials can vary from as low as 10 μ V to over 1 mV [55-57].…”

Section: Discussionmentioning

confidence: 99%

A Programmable Multi-Biomarker Neural Sensor for Closed-Loop DBS

et al. 2019

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Most of the current closed-loop DBS devices use a single biomarker in their feedback loop which may limit their performance and applications. This paper presents design, fabrication, and validation of a programmable multi-biomarker neural sensor which can be integrated into closed-loop DBS devices. The device is capable of sensing a combination of low-frequency (7-45 Hz), and high-frequency (200-1000 Hz) neural signals. The signals can be amplified with a digitally programmable gain within the range 50-100 dB. The neural signals can be stored into a local memory for processing and validation. The sensing and storage functions are implemented via a combination of analog and digital circuits involving preamplifiers, filters, programmable post-amplifiers, microcontroller, digital potentiometer, and flash memory. The device is fabricated, and its performance is validated through: (i) bench tests using sinusoidal and pre-recorded neural signals, (ii) in-vitro tests using pre-recorded neural signals in saline solution, and (iii) in-vivo tests by recording neural signals from freely-moving laboratory mice. The animals were implanted with a PlasticsOne electrode, and recording was conducted after recovery from the electrode implantation surgery. The experimental results are presented and discussed confirming the successful operation of the device. The size and weight of the device enable tetherless back-mountable use in pre-clinical trials.

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Section: Discussionmentioning

confidence: 99%

A Programmable Multi-Biomarker Neural Sensor for Closed-Loop DBS

et al. 2019

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“…Our device can provide simultaneous dual-biomarker-based (LFP and AP) recordings, while most of the previous devices [10], [54]–[57] only record one biomarker at the same time. Although the gain and bandwidth of the current device is fixed and non-adjustable compared to the devices reported in ref.…”

Section: Discussionmentioning

confidence: 99%

“…[54], [56], [57], our device benefits from a gain of 100 dB which is the highest gain achieved amongst the existing devices with a gain values between 35–100 dB. Moreover, in terms of the operating power supply, this device requires lower power voltage (3 V) compared to most of the existing devices with a minimum of 3.3 – 4 V power supply requirement [54]–[57]. The requirement for higher supply voltages results in the use of larger and heavier batteries, which can be avoided in our design because of lower supply requirements.…”

Section: Discussionmentioning

confidence: 99%

A Miniature Dual-Biomarker-Based Sensing and Conditioning Device for Closed-Loop DBS

Parastarfeizabadi

Kouzani

2019

IEEE J. Transl. Eng. Health Med.

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In this paper, a dual-biomarker-based neural sensing and conditioning device is proposed for closing the feedback loop in deep brain stimulation devices. The device explores both local field potentials (LFPs) and action potentials (APs) as measured biomarkers. It includes two channels, each having four main parts: (1) a pre-amplifier with built-in low-pass filter, (2) a ground shifting circuit, (3) an amplifier with low-pass function, and (4) a high-pass filter. The design specifications include miniature-size, light-weight, and 100 dB gain in the LFP and AP channels. This device has been validated through bench and in-vitro tests. The bench tests have been performed using different sinusoidal signals and pre-recorded neural signals. The in-vitro tests have been conducted in the saline solution that mimics the brain environment. The total weight of the device including a 3 V coin battery, and battery holder is 1.2 g. The diameter of the device is 11.2 mm. The device can be used to concurrently sense LFPs and APs for closing the feedback loop in closed-loop deep brain stimulation systems. It provides a tetherless head-mountable platform suitable for pre-clinical trials.

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“…They also reviewed the detailed stimulation parameters for electrical and optogenetic neuromodulations. The second paper is entitled "Development of wireless neural interface system" by Im et al [5]. This article introduces a wireless neural interface system (WNIS) for animal experiments.…”

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confidence: 99%