1990
DOI: 10.1155/1991/95302
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Developmental Expression of IL‐2‐Receptor Light Chain (CD25) in the Chicken Embryo

Abstract: Thymocyte differentiation obeys the same fundamental principles in mammals as in avian species. This parallelism does not only affect the developmentally controlled acquisition of CD3, 4, 8, and TcR isotype expression, but also concerns CD25, the light chain of the interleukin-2 receptor (IL-2R). On chicken thymocytes, surface CD25, which is recognized by the monoclonal antibody INN Ch16, is first observed during day 11 of embryonic life, and peaks at day 14, when it is expressed by about one-third of all lymp… Show more

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Cited by 11 publications
(2 citation statements)
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“…The current data indicate that rat T-cell precursors (TN cells) express IL-2 receptors, a fact previously denied by other authors (Takacs et al, 1988;Kampinga and Aspinall, 1990), although repeatedly reported in mice, chickens, and humans (Ceredig et al, 1985;Toribio et al, 1989;Fedecka-Brunner et al, 1991). In agreement with our results, Brocke et al (1987) found IL-2Rce-beating cells in the thymus of 16-day-old fetal rats.…”
Section: Discussionsupporting
confidence: 92%
“…The current data indicate that rat T-cell precursors (TN cells) express IL-2 receptors, a fact previously denied by other authors (Takacs et al, 1988;Kampinga and Aspinall, 1990), although repeatedly reported in mice, chickens, and humans (Ceredig et al, 1985;Toribio et al, 1989;Fedecka-Brunner et al, 1991). In agreement with our results, Brocke et al (1987) found IL-2Rce-beating cells in the thymus of 16-day-old fetal rats.…”
Section: Discussionsupporting
confidence: 92%
“…However, it is unclear whether chIL‐2 exerts biological function by binding its cell receptor. Some researchers had reported a monoclonal antibody (mAb) recognizing the activated chicken T lymphocytes [30–32]. In this study, a cell receptor binding to chIL‐2, named chicken CD25 (chCD25) according to human IL‐2R α chain (CD25), was expressed in prokaryotic and eukaryotic cells.…”
Section: Introductionmentioning
confidence: 99%