Developmental expression of the Notch signaling pathway genes during mouse preimplantation development

Characterizing the developmental pathways TTF-1 , NKX2–8 , and PAX9 in lung cancer

“…As such, this result suggests that these gene expression signatures represent tools to accurately profile the biological pathway status defined by each transcription factor. Importantly, gene annotation of the individual gene expression profiles using GATHER (11) further demonstrated that the TTF-1, NKX2-8, and PAX9 signatures are composed of genes/pathways that have previously been shown to be critical in both embryonal tissue development (JAK/STAT, Wnt, BMP, and Hedgehog) (12)(13)(14)(15) and more specifically lung development (MAPkinase, PI3kinase, and JAK/STAT) (Table S1) (15)(16)(17).…”

Notch1 signaling regulates chondrogenic lineage determination through Sox9 activation

“…EBs recapitulate several aspects of early development including germ layer formation and further differentiation into cartilage through the mesoderm and neural crest. 6,30 Components of the Notch pathway are present in mammalian cells during early stages of embryogenesis 31 and chondrogenesis, 4,7 and correct Notch signals are required for normal embryonic cartilage development. 8 Several in vitro and in vivo studies using gain of function and loss of function reported that increased Notch signaling inhibits chondrogenic differentiation, whereas Notch pathway loss of function results in hypertrophic cartilage and decreased bone formation.…”

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

“…Hormone and neurotransmitter receptors have also been found in oocytes and in female germline cells. For example, the oestrogen receptor (Wu et al 1992), serotonin receptor 5-HTID (Veselá et al 2003), Notch1 and Notch2 receptors (Cormier et al 2004), and the ␤2-andrenoceptor (Č ikoš et al 2005) have all been detected in oocytes, and the GH receptor has been detected in fertilized eggs (Pantaleon et al 1997;Kölle et al 2001). It is interesting to note that the changes in expression of some of the genes coding for these receptors coincide temporally with early waves of epigenetic re-programming during development.…”