The subtribe Astephaninae (tribe Asclepiadeae, Asclepiadaceae) is recircumscribed to contain 11 genera: Astephanus, Blyttia, Diplostigma, Goydera, Aiicroloma, Oncinema, Pentatropis, Pteurosteima, Rhyncharrhena, Schizostephanus, and Tylophoropsis. Following a character analysis, phylogeny was analysed by means of a computerized parsimony program (HENNIG86).Astephanus /Microloma is identified as the most stable clade, followed by Tylophopropsis/Pentatropis/Rhyncharrhena, Blyttia/Diplostigma and Schizostephanus/Goydera. A key to the genera is presented, as well as notes on distribution, important characters, and present state of knowledge for each genus. The genus Schizostephanus is resurrected and four new combinations are proposed.