Dexamethasone and post-dural puncture headache in women who underwent cesarean delivery under spinal anesthesia: A systemic review and meta-analysis of randomized controlled trials

Fenta, Efrem; Teshome, Diriba; Hunie, Metages

doi:10.1016/j.amsu.2021.01.024

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…All these therapies need more raw data to draw solid conclusions. Finally, the results of this study revealed that DXM and HCT, as the two most common glucocorticoids, were unable to reduce the incidence and severity of PDPH in parturients, which was consistent with the recent meta-analysis [ 17 ].…”

Section: Discussionsupporting

confidence: 91%

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Efficacy of pharmacological therapies for preventing post-dural puncture headaches in obstetric patients: a Bayesian network meta-analysis of randomized controlled trials

Zhao

Song

Liu

2023

BMC Pregnancy Childbirth

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Background Post-dural puncture headache (PDPH) is a major complication of neuraxial anesthesia. PDPH usually occurs after Caesarean section in obstetric patients. The efficacy of prophylactic pharmacological therapies remains controversial. Methods Seven pharmacological therapies (aminophylline (AMP), dexamethasone, gabapentin/pregabalin (GBP/PGB), hydrocortisone, magnesium, ondansetron (OND), and propofol (PPF)), were studied in this Bayesian network meta-analysis. The primary outcome was the cumulative incidence of PDPH within 7 days. Secondary outcomes included the incidence of PDPH at 24 and 48 h postoperatively, the severity of headache in PDPH patients (24, 48, and 72 h postoperatively), and postoperative nausea and vomiting (PONV). Results Twenty-two randomized controlled trials with 4,921 pregnant women (2,723 parturients received prophylactic pharmacological therapies) were included. The analyses demonstrated that PPF, OND, and AMP were efficient in decreasing the cumulative incidence of PDPH during the follow-up period compared to the placebo group (OR = 0.19, 95% CI: 0.05 to 0.70; OR = 0.37, 95% CI: 0.16 to 0.87; OR = 0.40, 95% CI: 0.18 to 0.84, respectively). PPF and OND had the lower incidence of PONV compared to the placebo group (OR = 0.07, 95% CI: 0.01 to 0.30; and OR = 0.12, 95% CI: 0.02 to 0.63). No significant difference in other outcomes was found among different therapies. Conclusions Based on available data, PPF, OND, and AMP may have better efficacy in decreasing the incidence of PDPH compared to the placebo group. No significant side effects were revealed. Better-designed studies are requested to verify these conclusions.

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Section: Discussionsupporting

confidence: 91%

“…Several pharmacological therapies for preventing PDPH have been developed in parturients, including aminophylline (AMP), dexamethasone (DXM), gabapentin/pregabalin (GBP/PGB), hydrocortisone (HCT), magnesium (Mg), ondansetron (OND), and propofol (PPF) [ 15 – 17 ]. However, the results were inconsistent.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of pharmacological therapies for preventing post-dural puncture headaches in obstetric patients: a Bayesian network meta-analysis of randomized controlled trials

Zhao

Song

Liu

2023

BMC Pregnancy Childbirth

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“…Similarly, (Shahbazi et Most of the caesarean women suffer from headache, vomiting, and nausea for taking higher level of antibiotic, especially very common for them who underwent caesarean delivery providing spinal anesthesia. As stated by (Fenta et al, 2021) post-dural puncture headache and vomiting are common complications after spinal anesthesia for women who undergo caesarean delivery. Caesarean delivery, like any major surgery, comes with a number of risks.…”

Section: Short Term Health Risks and Complexities Of Caesarean Mother...mentioning

confidence: 99%

Short and Long-Term Health Risks and Complexities among Caesarean Mothers and Babies in Bangladesh: A Case Study

Ara

Seddiky

Bappy

2022

Int J Health Sci Res

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The number of caesarean deliveries in Bangladesh, like other developed countries in the world, has increased at an alarming rate. Contrary to conventional deliveries, C-section births are more dangerous and difficult, albeit they are occasionally unavoidable. This paper aimed at exploring the health risks and complexities of caesarean mothers and babies in Bangladesh. Researchers organized a field study in Sylhet district, the northeastern part of Bangladesh, and interviewed in persons with 45 participants including doctors from two medical college hospitals and mothers who underwent caesarean sections applying purposive sampling technique. Researchers used thematic analysis method for analyzing primary data. Researchers applied two cycle coding (open coding and selective coding) to formulate the large themes. Research findings reveal that most of the mother participants got caesarean delivery only for avoiding pain without having any pregnancy complexities. This unplanned decisions regarding the birth style lead to serious concerns on the health systems of mother and babies including bleeding, over pain, increased infections, injury to the organs, problems in the future pregnancy, premature birth, asthma, diabetes-1 and other physical and psychological problems. Besides, these risks tend to be higher in Bangladesh due to lack of expertise doctors, technology, infrastructure, awareness and weak management systems. Hopefully, this study findings would be a guideline for the future researchers, policy makers, practitioners, and relevant communities to avoid unplanned Caesars and minimize the health risks of caesarean mothers and babies. Key words: Caesarean, risks, complexities, mother, babies, and Bangladesh

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“…[1][2][3] One of the most common complications after procedures is post-dural puncture headache (PDPH), which usually develops within 5 days after lumbar puncture. 1,[4][5][6][7] Despite international guidelines, lumbar puncture procedures vary from setting to setting based on individual's traditions and experience. 1 Similarly, care of the postlumbar punctures also varied greatly.…”

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confidence: 99%

Simple and less cost but not effective

Lee

Chang

Wang

2021

Journal of the Chinese Medical Association

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Dexamethasone and post-dural puncture headache in women who underwent cesarean delivery under spinal anesthesia: A systemic review and meta-analysis of randomized controlled trials

Cited by 4 publications

References 31 publications

Efficacy of pharmacological therapies for preventing post-dural puncture headaches in obstetric patients: a Bayesian network meta-analysis of randomized controlled trials

Efficacy of pharmacological therapies for preventing post-dural puncture headaches in obstetric patients: a Bayesian network meta-analysis of randomized controlled trials

Short and Long-Term Health Risks and Complexities among Caesarean Mothers and Babies in Bangladesh: A Case Study

Simple and less cost but not effective

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