2012
DOI: 10.1253/circj.cj-12-0171
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Dexmedetomidine and Clonidine Inhibit Ventricular Tachyarrhythmias in a Rabbit Model of Acquired Long QT Syndrome

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Cited by 28 publications
(16 citation statements)
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“…Dexmedetomidine increased the dysrhythmogenic threshold of epinephrine during halothane anesthesia in canines2 and showed an inhibitory effect on ventricular tachyarrhythmia in a rabbit model of acquired long QT syndrome 3. On the contrary, Hammer, et al4 showed that dexmedetomidine significantly prolonged QTc intervals in pediatric patients, which contrasts with our results.…”
Section: Discussioncontrasting
confidence: 99%
See 1 more Smart Citation
“…Dexmedetomidine increased the dysrhythmogenic threshold of epinephrine during halothane anesthesia in canines2 and showed an inhibitory effect on ventricular tachyarrhythmia in a rabbit model of acquired long QT syndrome 3. On the contrary, Hammer, et al4 showed that dexmedetomidine significantly prolonged QTc intervals in pediatric patients, which contrasts with our results.…”
Section: Discussioncontrasting
confidence: 99%
“…Alpha-2-adrenoreceptor is distributed throughout the brain stem, peripheral vasculature, and presympathetic nervous terminal as an auto-suppressive receptor. The receptor suppresses its own adrenal release from the terminal reticulum to the effecter, including the brain system, vasculature, and the heart, achieving sedation, analgesia, decreased blood pressure and bradycardia 3. Alpha-2-adrenoreceptor agonist modifies the cardiac autonomic state not only by suppressing cardiac noradrenaline release, but also by activating vagal acetylcholine release 24,25.…”
Section: Discussionmentioning
confidence: 99%
“…However, only limited evidence supporting this exists in the literature. Clonidine attenuates QT prolongation in some experimental models Modulation of QT interval duration in hypertension J Klimas et al of rat 134 and rabbit, 135 and its effects on QT variability have been suggested in humans. 136 The relationship between these effects and BP remains questionable.…”
Section: Diureticsmentioning
confidence: 99%
“…α 2 -adrenoceptor agonists attenuate L-type calcium channels and supress EADs. Promising results were obtained for clonidine and dexmedetomidine, with both drugs shortening the QT interval and reducing the incidence of TdP in a rabbit model of aLQTS [47].…”
mentioning
confidence: 99%