Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes

Li, Yan; Fan, Yumei; Shaikh, Abdul Sami; Wang, Zhendong; Wang, Dongliang; Tan, Haining

doi:10.1016/j.jep.2019.112221

Cited by 37 publications

(65 citation statements)

References 28 publications

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“…In addition to its antioxidant, anti-microbial, anti-inflammatory and anti-tumoral activity, DM also has an anti-diabetic effect (Table 5) [61,76,77]. [74] β-lactoglobuline Antihypertensive [74] Type 2 diabetes, also known as non-insulin-dependent diabetes, is a metabolic disease characterized by chronic excess blood sugar (hyperglycemia).…”

Section: Anti-diabetic and Anti-obesity Activity Of Donkey Milkmentioning

confidence: 99%

“…In addition to its antioxidant, anti-microbial, anti-inflammatory and anti-tumoral activity, DM also has an anti-diabetic effect ( Table 5 ) [ 61 , 76 , 77 ].…”

Section: Anti-diabetic and Anti-obesity Activity Of Donkey Milkmentioning

confidence: 99%

“…Li et al, in 2020 [ 76 ], have shown that DM improves the viability of damaged pancreatic β cells, but does not stimulate the secretion of insulin by damaged β cells and that the α-lactalbumin increases the insulin sensitivity of the target organs. DM has shown a better effect than metformin, an anti-diabetic drug for treating type 2 diabetes [ 76 ].…”

Section: Anti-diabetic and Anti-obesity Activity Of Donkey Milkmentioning

confidence: 99%

“…Considering its functional properties and its nutritional values, DM becomes an attractive product for health, technology, cosmetic industry, and others. The health effects of DM consumption are mainly related to low allergenicity [ 3 , 5 , 67 , 68 ], anti-microbial activity [ 5 , 32 , 42 , 43 , 44 , 57 , 69 , 70 ], regulation of iron homeostasis [ 5 ], anti-inflammatory and immune system modulation, innate immune system, immunosenescence [ 5 , 20 , 71 , 72 ], anti-hypertensive [ 5 , 73 , 74 , 75 ], anti-diabetic [ 76 ], anti-tumoral [ 5 , 77 , 78 ], stimulate development [ 5 , 68 ], anti-stress and anti-oxidant activity [ 5 , 25 , 65 , 76 ], and anti-osteoporosis [ 5 , 68 , 79 ] ( Figure 2 ). DM is supplied in different forms: liquid milk, fermented products (with higher peptide content and bioavailable calcium source), freeze dried, and spray dried powders [ 87 ].…”

Section: Food and Other Applications Of Donkey Milkmentioning

confidence: 99%

“…Anti-diabetic activity [76]; Protection against cancer development [5,77,78]; 8. Stimulate development [5,68]; 9.Anti-stress, anti-oxidant effects[5,25,65,76]; 10. Stimulate bone mineralization[5,68,79].…”

mentioning

confidence: 99%

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Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview

Derdak

Sakoui

Pop

et al. 2020

Foods

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Due to its similarity with human milk and its low allergenic properties, donkey milk has long been used as an alternative for infants and patients with cow’s milk protein allergy (CMPA). In addition, this milk is attracting growing interest in human nutrition because of presumed health benefits. It has antioxidant, antimicrobial, antitumoral, antiproliferative and antidiabetic activity. In addition, it stimulates the immune system, regulates the gastrointestinal flora, and prevents inflammatory diseases. Although all donkey milk components can contribute to functional and nutritional effects, it is generally accepted that the whey protein fraction plays a significant role. This review aims to highlight the active proteins and peptides of donkey milk in comparison with other types of milk, emphasizing their properties and their roles in different fields of health and food applications.

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Section: Anti-diabetic and Anti-obesity Activity Of Donkey Milkmentioning

confidence: 99%

“…In addition to its antioxidant, anti-microbial, anti-inflammatory and anti-tumoral activity, DM also has an anti-diabetic effect ( Table 5 ) [ 61 , 76 , 77 ].…”

Section: Anti-diabetic and Anti-obesity Activity Of Donkey Milkmentioning

confidence: 99%

Section: Anti-diabetic and Anti-obesity Activity Of Donkey Milkmentioning

confidence: 99%

Section: Food and Other Applications Of Donkey Milkmentioning

confidence: 99%

mentioning

confidence: 99%

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Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview

Derdak

Sakoui

Pop

et al. 2020

Foods

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Goat Milk Improves Glucose Metabolism in Type 2 Diabetic Mice and Protects Pancreatic β‐Cell Functions

Chen,

Zhang,

Niu

et al. 2023

Molecular Nutrition Food Res

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ScopeConsuming goat milk is known to benefit high‐fat diet‐fed and streptozocin (STZ)‐induced diabetic rats, but the underlying mechanisms are unknown. This study is conducted to investigate the metabolic effects of a goat milk diet (a form of goat milk powder) on glucose homeostasis and pancreatic conditions in a mouse model of Type 2 diabetes mellitus (T2DM) induced by STZ.Methods and resultsT2DM mice are fed with a goat‐milk‐based diet containing 10.3% w/w goat milk powder for 10 weeks for investigating the in vivo effects; a β‐cell line MIN6 cells are used to test the in vitro effects of digested goat milk (DGM). Goat milk diet improves the deleterious effects of STZ on fasting glucose levels and glucose tolerance, accelerates pancreatic structure recovery, and alters blood metabolites in mice. Based on the significant differences observed in metabolites, the key pathways, metabolite regulatory enzymes, metabolite molecular modules, and biochemical reactions are identified as critical integrated pathways. DGM promotes the cell activity, glucose transportation, and AKT activation in cultured STZ‐treated MIN6 cells in vitro.ConclusionsGoat milk diet improves glucose homeostasis and pancreatic conditions of T2DM mice, in association with improved blood metabolite profiles and activation of pancreatic AKT pathway.

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Protective Effects of Donkey Milk on Ethanol‐Induced Gastric Ulcer in Rat

Sami,

Azizi,

Kheirandish

et al. 2024

Veterinary Medicine & Sci

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Gastric ulcer (GU) is the most common health concern that occurs due to an imbalance between gastric protective mucosal and aggressive factors. Ethanol‐induced GU in animal models resembles the pathophysiology of human ulcers. Natural products with fewer side effects are highly requested to attenuate their GU effects. The present study was conducted to investigate the potential protective effects of donkey milk against ethanol‐induced GU in rats. The male Wistar were divided into four groups, including normal control (distilled water), donkey milk (1 cm3/animal) and ranitidine (200 mg/kg). Donkey milk and ranitidine were given to rats orally daily for 10 consecutive days before induction of ulcer by ethanol. After 24 h of fasting, GU was induced by oral administration of ethanol. After an hour, the rats were sacrificed, and gastric samples were taken for pathologic analysis, malondialdehyde (MDA) and glutathione (GSH) assessments. The results showed that the severity of ethanol‐induced gastric damage was significantly reduced by donkey's milk pretreatment and then ranitidine. Reduction of ulcer score and MDA level, and also increasing GSH in the gastric tissue in comparison with other groups supports our results. This study described the gastroprotective and antioxidative effects of donkey milk that were determined with ulcer inhibition percentage.

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Dezhou donkey (Equus asinus) milk a potential treatment strategy for type 2 diabetes

Cited by 37 publications

References 28 publications

Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview

Insights on Health and Food Applications of Equus asinus (Donkey) Milk Bioactive Proteins and Peptides—An Overview

Goat Milk Improves Glucose Metabolism in Type 2 Diabetic Mice and Protects Pancreatic β‐Cell Functions

Protective Effects of Donkey Milk on Ethanol‐Induced Gastric Ulcer in Rat

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