„Diabesity“ – Adipositas und Typ-2-Diabetes (Update 2019)

Toplak, Hermann; Leitner, Deborah R.; Harreiter, Jürgen; Hoppichler, Friedrich; Wascher, Thomas C.; Schindler, Karin; Ludvik, Bernhard

doi:10.1007/s00508-018-1418-9

Cited by 35 publications

(29 citation statements)

References 58 publications

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“…Indeed, based on data from meta-analyses (12,(22)(23)(24)(25)(26)(27)(28)(30)(31)(32) , our model was parameterised so that an increase in energy intake resulted in an increased T2D risk, as a function of the BMI and level of physical activity of the subjects. Under this model, a change in energy intake is an important factor for risk estimates, in line with the importance of energy imbalances in being overweight and of being overweight in the T2D risk, as highlighted in the literature (44) . However, although energy density and portion size are key drivers of a long-term energy imbalance, mechanisms for adjustment to subsequent energy intake should partly buffer the impact of a difference in energy content between two dishes on long-term energy intake.…”

Section: Discussionsupporting

confidence: 55%

Impact of intra-category food substitutions on the risk of type 2 diabetes: a modelling study on the pizza category

et al. 2021

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Advice on replacing unhealthy foods with healthier alternatives within the same food category may be more acceptable and might ease the transition towards a healthy diet. Here, we studied the potential impact of substitutions within the pizza category on the risk of type 2 diabetes (T2D). The study sample consisted of 2,510 adults from the INCA2 French national survey. Based on their nutritional characteristics, the 353 pizzas marketed in France were grouped in 100 clusters that were used to run various scenarios of pizza substitutions, which were either isoenergetic (IE) or non-isoenergetic (NIE). We then used a model structurally similar to the Preventable Risk Integrated ModEl (PRIME) to assess the expected rate of change in risk of T2D. Pizzas characterized by a low energy, high vegetable content and whole grain dough were associated with a greater reduction in the risk of T2D. The rates of change in risk of T2D were markedly stronger in men and for NIE substitutions. When the rates of change were estimated in the subsample of pizza consumers, replacing the observed pizzas with the best pizza resulted in a T2D risk reduction of −6.7% (−8.4%; −4.9%, IE) and −8.9% (−11.2%; −6.3%, NIE), assuming that this is their usual diets. The greatest risk reduction induced by an IE substitution of the observed pizza with a mixed dish was similar to that observed with the best pizzas. Overall, this modelling study suggests that healthy swaps within a category can effectively supplement broader dietary changes toward a healthier diet.

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Section: Discussionsupporting

confidence: 55%

Impact of intra-category food substitutions on the risk of type 2 diabetes: a modelling study on the pizza category

et al. 2021

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“…However, using body mass (or body mass index) as a measure of obesity is extremely crude [ [81] , [82] , [83] ] and may miss more subtle effects on body composition changes. That appears to be the case here, because although food intake increased enormously as it got colder this intake was insufficient to meet the elevated thermoregulatory requirements, and increasingly so as it got colder.…”

Section: Discussionmentioning

confidence: 99%

Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

Zhao

Yang

et al. 2022

Molecular Metabolism

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“…Nowadays, this procedure is indicated when the BMI > 35 kg/m 2 (this value corresponds to a type II obesity) and it is necessary to be incorporated into a proper context of care and permanent medical assistance [ 64 ]. However, other studies demonstrated that this procedure may produce higher benefits in patients with a BMI ≥ 27 compared to intensive medical therapy in terms of glycaemia controlling and weight loss, reporting better results even in their quality of life [ 65 ], thus denoting the possibility of considering this alternative in the clinical management of diabesity. On the other hand, despite its effectivity, its high price, the possible complications associated, and the invasiveness of the procedure are other factors to be taken into account when selecting the proper therapy for each patient [ 66 ].…”

Section: Clinical Management Of Diabesitymentioning

confidence: 99%

Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

et al. 2020

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Obesity is a condition of rising prevalence worldwide, with important socioeconomic implications, being considered as a growing public health concern. Frequently, obesity brings other complications in addition to itself—like Type 2 Diabetes Mellitus (T2DM)—sharing origin, risk factors and pathophysiological mechanisms. In this context, some authors have decided to include both conditions as a unique entity known as “diabesity”. In fact, understanding diabesity as a single disease is possible to maximise the benefits from therapies received in these patients. Gut microbiota plays a key role in individual’s health, and their alterations, either in its composition or derived products are related to a wide range of metabolic disorders like T2DM and obesity. The present work aims to collect the different changes reported in gut microbiota in patients with T2DM associated with obesity and their possible role in the onset, development, and establishment of the disease. Moreover, current research lines to modulate gut microbiota and the potential clinical translation derived from the knowledge of this system will also be reviewed, which may provide support for a better clinical management of such a complex condition.

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„Diabesity“ – Adipositas und Typ-2-Diabetes (Update 2019)

Cited by 35 publications

References 58 publications

Impact of intra-category food substitutions on the risk of type 2 diabetes: a modelling study on the pizza category

Impact of intra-category food substitutions on the risk of type 2 diabetes: a modelling study on the pizza category

Effects of ambient temperatures between 5 and 35 °C on energy balance, body mass and body composition in mice

Type 2 Diabetes Mellitus Associated with Obesity (Diabesity). The Central Role of Gut Microbiota and Its Translational Applications

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