Diabetes, blood lipids, lipoproteins, and change of environment: Restudy of the “new immigrant Yemenites” in Israel

Cohen, A.M.; Fidel, Joseph; Cohen, Beth E.; Furst, A.; Eisenberg, Shlomo

doi:10.1016/0026-0495(79)90176-8

Cited by 22 publications

(9 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…12,13 Sharma (1970) and Jain (1980) observed increase in the levels of serum total lipids, total cholesterol, serum triglycerides and serum phospholipids in diabetic subjects as compared to normal controls. 14,15 Several other studies have shown similar results as were obtained in our study (16,17,18).…”

supporting

confidence: 88%

Comparison of Lipid Profile in Type-2 Obese Diabetics and Obese Non-diabetic Individuals. A hospital Based Study from Western Nepal

Yadav

Thanpari

Shrewastwa

et al. 2013

Kathmandu Univ. Med. J.

View full text Add to dashboard Cite

BackgroundType-2 diabetes mellitus is an independent risk factor for coronary artery disease and risk of coronary disease is three to four fold increased in patients with diabetes compared with non-diabetic population and 60-80% 0f type-2 diabetics are obese. MethodsThis study was conducted in Nepalgunj Teaching Hospital, Kohalpur, Banke, Nepal, between 1st March, 2011 and 28th February, 2012. A total of 150 samples were taken to assess the lipid profile in type-2 diabetic patients associated with obesity and 25 obese controls for their lipid profile. Venous blood samples were taken from all the subjects in the morning after fasting overnight. Exclusion criteria included pregnancy, chronic infectious disease, heart failure; renal failure and drug allergy were confirmed from the subject's personal physician report and a detailed history. The data was analyzed using Excel 2003, R 2.8.0 Statistical Package for the Social Sciences (SPSS) for Windows Version 16.0 (SPSS Inc; Chicago, IL, USA) and the EPI Info 3.5.1 Windows Version. ResultsThe mean ± SD age of diabetic patients with obesity was 53.76 ± 6.23 while the mean ± SD age of control was 49.61 ± 4.8. Out of 150 patients 105 (70%) were males and 45 (30%) were females. Among control subjects 16 (64%) were males and 9 (36%) were females. Obese type-2 diabetic patients when compared to obese control subjects showed statistically significant increase in the levels of serum total cholesterol (p ˂ 0.001), serum triglycerides (p ˂ 0.001), serum LDL-cholesterol (p ˂ 0.001) while serum HDL-cholesterol levels did not show statistically significant difference in the two group (p ˃ 0.05). ConclusionThis study showed obese diabetic individuals have dyslipidemia and more prone to develop cardiovascular diseases.

show abstract

supporting

confidence: 88%

Comparison of Lipid Profile in Type-2 Obese Diabetics and Obese Non-diabetic Individuals. A hospital Based Study from Western Nepal

Yadav

Thanpari

Shrewastwa

et al. 2013

Kathmandu Univ. Med. J.

View full text Add to dashboard Cite

show abstract

“…An analogous clinical counterpart apparently exists among Yemenite Jews in whom increased sucrose intake has been blamed for the greater incidence not only of hypertension 16 but also of diabetes mellitus. 17 Inasmuch as the slight blood pressure elevation induced by sucrose ingestion has thus far been demonstrated only by indirect measurement with the tail-cuff method, we first confirmed its existence by direct measurement from indwelling femoral catheters. Upon finding that rats given sucrose indeed become mildly hypertensive, blood pressure responses to hypothalamic stimulation and a-adrenergic blockade with phentolamine were recorded to test the possibility that hypothalamic regulation of sympathetic activity had been altered.…”

supporting

confidence: 51%

Chronic sucrose ingestion induces mild hypertension and tachycardia in rats.

Buñag¹,

Tomita²,

Sasaki³

1983

Hypertension

View full text Add to dashboard Cite

As a means for increasing sympathetic activity, male weanling rats were given 8% sucrose solution to drink instead of water. After 5 weeks, systolic pressures measured with a tail-cuff method became appreciably elevated, and the elevation was verified when phasic pressures were later recorded directly from femoral catheters. Successful induction of sympathetic overactivity was considered a likely explanation because sucrose-ingesting rats, compared with untreated controls, had faster heart rates and larger hypotensive responses to alpha-adrenergic blockade with phentolamine. Upon graded electrical stimulation of the ventromedial hypothalamus under urethane anesthesia, resulting pressor and sympathetic nerve responses were also larger in sucrose-treated rats. By contrast, pressor responses to injections of norepinephrine or tyramine were unaffected, thereby indicating that cardiovascular sensitivity had not been enhanced by sucrose ingestion. During intravenous glucose tolerance tests, increases in plasma insulin were consistently lower in sucrose-treated than control rats even though corresponding increases in plasma glucose were just transiently higher. These results support the interpretation that chronic sucrose ingestion inhibits pancreatic insulin secretion and elevates blood pressure by stimulating the ventromedial hypothalamus to increase sympathetic activity.

show abstract

“…However, the dramatic increase in the prevalence of diabetes in many other populations after adoption of Western or urban life-styles has been well documented (6,27,(32)(33)(34)(35)(36)(37). With this phenomenon in mind, one possible interpretation of our data is that the groups with higher prevalence rates were the first to be influenced by Caucasian groups.…”

Section: Discussionmentioning

confidence: 57%

Prevalence of Diabetes Mellitus in Alaskan Eskimos, Indians, and Aleuts

Schraer

Lanier²,

Boyko³

et al. 1988

Diabetes Care

View full text Add to dashboard Cite

The prevalence of diabetes mellitus in Alaska Natives has been thought to be low, but no survey of this condition in all natives has been conducted. Medical records from 1979 to 1985 were reviewed to determine the prevalence of diagnosed diabetes mellitus in Alaska Natives. Computerized outpatient and inpatient medical record data and clinician reports were used to identify cases. As of December 1985, 610 living Alaska Natives fulfilled diagnostic criteria for diabetes. Type II diabetes mellitus was found in 564 subjects, type I diabetes was found in 15 subjects, and unspecified type of diabetes was found in 31 subjects. The overall age-adjusted prevalence of diabetes mellitus, 15.7/1000, was lower than the overall United States rate of 24.7/1000. However, age-adjusted prevalence varied considerably by ethnic group; the prevalence was 27.2/1000 among Aleuts, 22.0/1000 among Alaskan Indians, and 8.8/1000 among Alaskan Eskimos. Rates within the Eskimo subgroups varied by a factor of four. Compared with previous reports, the prevalence of diabetes mellitus in Alaskan Eskimos appears to have increased. Diabetes mellitus is no longer a rare condition among Alaska Natives.

show abstract

Diabetes, blood lipids, lipoproteins, and change of environment: Restudy of the “new immigrant Yemenites” in Israel

Cited by 22 publications

References 44 publications

Comparison of Lipid Profile in Type-2 Obese Diabetics and Obese Non-diabetic Individuals. A hospital Based Study from Western Nepal

Comparison of Lipid Profile in Type-2 Obese Diabetics and Obese Non-diabetic Individuals. A hospital Based Study from Western Nepal

Chronic sucrose ingestion induces mild hypertension and tachycardia in rats.

Prevalence of Diabetes Mellitus in Alaskan Eskimos, Indians, and Aleuts

Contact Info

Product

Resources

About