Diabetes, but not the metabolic syndrome, predicts the severity and extent of coronary artery disease in women

Zornitzki, Taiba; Ayzenberg, Oded; Gandelman, Gera; Vered, Shiraz; Yaskil, E.; Faraggi, David; Caspi, Avraham; Goland, Sorel; Shvez, O.; Schattner, A.; Knobler, Hilla

doi:10.1093/qjmed/hcm066

Cited by 30 publications

(30 citation statements)

References 41 publications

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“…In multivariate analysis, high triglycerides and low HDL were predictors of angiographically proven CAD. 8 In our study, we also observed a direct relationship between diabetes and CAD and no relationship with metabolic syndrome. We also confirmed the importance of triglycerides as a predictor of CAD.…”

Section: Discussionsupporting

confidence: 65%

Does metabolic syndrome predict significant angiographic coronary artery disease?

Timóteo

Carmo

Ferreira

2012

Revista Portuguesa de Cardiologia

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Introduction: Metabolic syndrome (MS) is an independent predictor of acute cardiovascular events. However, few studies have addressed the relationship between MS and stable angiographic coronary artery disease (CAD), which has a different pathophysiological mechanism. We aimed to study the independent predictors for significant CAD, and to analyze the impact of MS (by the AHA/NHLBI definition) on CAD. Methods: We prospectively included 300 patients, mean age 64 ± 9 years, 59% male, admitted for elective coronary angiography (suspected ischemic heart disease), excluding patients with known cardiac disease. All patients underwent assessment of demographic, anthropometric, and laboratory data and risk factors, and subsequently underwent coronary angiography. Results: In the study population, 23.0% were diabetic, 40.5% had MS (and no diabetes) and 36.7% had neither diagnosis. Significant CAD was present in 51.3% of patients. CAD patients were older and more frequently male and diabetic, with increased triglycerides and glucose and lower HDL cholesterol. Abdominal obesity was also less prevalent. MS was not associated with the presence of CAD (OR 0.94, 95% CI 0.59---1.48, p=0.778). Of the MS components, the most important predictors of CAD were increased glucose and triglycerides. Abdominal obesity was associated with a lower risk of CAD. In a multivariate logistic regression model for CAD, independent predictors of CAD were age, male gender, glucose and triglycerides. Body mass index had a protective effect. Conclusions: Although MS is associated with cardiovascular events, the same was not found for stable angiographically proven CAD. Age, gender, diabetes and triglycerides are the most influential factors for CAD, with abdominal obesity as a protective factor. Resumo Introdução: A síndrome metabólica (SM) é um predizente independente de eventos cardiovasculares agudos. Contudo, pouco estudos analisaram a relação entre SM e doença arterial coronária angiográfica estável (DAC), que apresenta uma diferente mecanismo fisiopatológico. Procurámos identificar os factores predizentes independentes para DAC e analisar o impacto da presença de SM (pela definição da AHA/NHLBI) na DAC. Métodos: Analisamos prospectivamente 300 indivíduos, com idade media de 64 ± 9 anos, 59% do género masculino, admitidos para angiografia coronária eletiva por suspeita de cardiopatia isquémica, tendo sido excluídos os doentes com antecedentes de doença cardíaca. Todos os doentes foram submetidos a avaliação demográfica, antropométrica, fatores de risco e laboratorial e subsequentemente a coronariografia. Resultados: Na população do estudo, 23,0% eram diabéticos, 40,5% tinha SM (sem diabetes) e 36,7% nenhum dos anteriores diagnósticos. Verificou-se DAC significativa em 51,3% dos doentes. Estes doentes tinham mais idade, mais do género masculino, diabéticos, com triglicéridos e glicemia aumentados e colesterol-HDL baixo. A obesidade abdominal era também menos prevalente. A SM não se associou com a presença de DAC (OR 0,94, IC 95% 0,59--...

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Section: Discussionsupporting

confidence: 65%

Does metabolic syndrome predict significant angiographic coronary artery disease?

Timóteo

Carmo

Ferreira

2012

Revista Portuguesa de Cardiologia

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“…Patients with MS are at increased risk of cardiovascular events (2-fold increase in cardiovascular outcomes, cardiovascular mortality, myocardial infarction and stroke, and a 1.5-fold increase in all-cause mortality) [3,4]. However, there is still a controversy about the association of MS with stable coronary artery disease (CAD) [5][6][7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%

Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions

Aykan¹,

Gül

Kalaycıoğlu

et al. 2014

Cardiol J

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Background: The aim of the present study was to assess the relation between metabolic syndrome (MS) and coronary artery disease (CAD) complexity, assessed by (p = 0.168, z = -1.38). The systolic blood pressure (p < 0.001, B = 0.354, 95% CI = -0.308 to 0.228), diastolic blood pressure (p = 0.006, B = -0.194, 95% CI = -0.333 to -0.056), age (p = 0.014, B = 0.147, 95% CI = 0.029 to 0.264), left ventricular ejection fraction (p = 0.031, B = -0.150, 95% CI = -0.286 to -0.014), waist/hip circumference (p < 0.001, B = 45.713, 95% CI = 23.235 to 68.1919) and log10 high density lipoprotein (p < 0.001, B = -22.209, 95% CI = -33.298 to -11.119) were the independent predictors of SS in linear regression analysis. Conclusions: MS is associated with the presence and complexity of CAD. Besides the presence of discrepancy in the limits of waist circumference, both IDF and AHA/NHLBI criteria were similarly correlated with CAD complexity. (Cardiol J 2014; 21, 3: 245-251)

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“…In an earlier study by Zornitzki et al, however, the authors did not find an association between the severity of coronary disease and the presence of MetSx [31]. Several differences between the 2 studies exist and might explain the non-congruent findings.…”

Section: Discussionmentioning

confidence: 84%

Likelihood of obstructive coronary disease in metabolic syndrome patients with abnormal stress echocardiography

Badarin

From

McCully

et al. 2011

International Journal of Cardiology

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Diabetes, but not the metabolic syndrome, predicts the severity and extent of coronary artery disease in women

Abstract: Diabetes, fasting plasma glucose and hypertension, but not the metabolic syndrome, were associated with severity of coronary angiographic findings in these women.

Cited by 30 publications

References 41 publications

Does metabolic syndrome predict significant angiographic coronary artery disease?

Does metabolic syndrome predict significant angiographic coronary artery disease?

Is metabolic syndrome related with coronary artery disease severity and complexity: An observational study about IDF and AHA/NHLBI metabolic syndrome definitions

Likelihood of obstructive coronary disease in metabolic syndrome patients with abnormal stress echocardiography

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