Diabetes detrimental effects on enamel and dentine formation

Type 1 diabetes mellitus effects on dental enamel formation revealed by microscopy and microanalysis

“…In fact, diabetic animals showed an expressive decrease in body weights from day 14 onwards in comparison with control ones (Table ). These results corroborate the findings recently reported by Abbassy et al Renal failure resulting from extremely high blood sugar level during a long experimental period was not prevented in the present study. It is important to remark, however, that 57 days were here used as a required period for detecting defects in rat incisors’ mature enamel which had been secreted and hardened previously in the experimental timeline.…”

“…This finding may be related to a little reduction in thickness of secretory stage EOECM layer (Figure A,B,C,D) as a consequence of the great weight loss of diabetic rats (at day 54, they exhibited approximately sixty percent of weight showed by control rats; Table ). It is also in agreement with previous reports on decrease in the thickness of enamel layer (secretory and mature) resulting from experimental diabetes, whose characteristic hyperglycemia might interfere in ameloblastic activity . In fact, we have previously associated thinner secretory stage EOECM with decreased birefringence…”

“…Streptozotocin has been effective in demonstrating various detrimental effects induced by T1DM on different organs and tissues of the body . Here, blood glucose level of 320 mg/dL was considered as the cutoff point for including streptozotocin‐treated animals in Diabetes group.…”

“…The current knowledge on the effects of T1DM on tooth development outcomes from few scientific studies . Tooth development is characterized by cell‐cell and cell‐extracellular matrix (ECM) exchanges that result in differentiation of odontoblasts and ameloblasts, which produce dentin and enamel, respectively .…”

Complication of Type 1 Diabetes in Craniofacial and Dental Hard Tissue

“…However, the type 1 diabetes group showed a significant decrease in the thickness of enamel and dentine surfaces when compared to the control group (Fig. 13) [79]. Graph showing that there is no significant difference in the incisor enamel and dentine mineral densities between the control and T1DM groups.…”