Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis

Lo, Lisa; McLennan, Susan V.; Williams, Paul F.; Bonner, J.G.; Chowdhury, Shyamal; McCaughan, Geoffrey W.; Gorrell, Mark D.; Yue, Dennis K.; Twigg, Stephen M.

doi:10.1016/j.jhep.2010.10.039

Cited by 92 publications

(115 citation statements)

References 52 publications

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“…Besides the direct effects of inflammatory cytokines on lipogenesis and fibrogenesis, TNF-␣ and IL-1␤ can induce insulin resistance (10,11). Importantly, insulin resistance is further associated with the development of steatosis and liver fibrosis (19,24,28). We found that insulin sensitivity was improved in CCR2 Ϫ/Ϫ mice with decreased expression of inflammatory cytokines after CDAA diet feeding.…”

Section: Fig 2 Steatohepatitis Is Attenuated In Ccr2mentioning

confidence: 69%

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Miura

Yang

Rooijen

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

441

385

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Section: Fig 2 Steatohepatitis Is Attenuated In Ccr2mentioning

confidence: 69%

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Miura

Yang

Rooijen

et al. 2012

American Journal of Physiology-Gastrointestinal and Liver Physi

441

385

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“…An animal model of type 2 diabetes model was developed by a classic method, namely feeding C57BL/6J mice with HFSD (27,28). The serum parameters associated with glucose metabolism were determined to observe the symptom of insulin resistant.…”

Section: Discussionmentioning

confidence: 99%

Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4

Wang

Zhao

et al. 2016

Journal of Bioscience and Bioengineering

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“…Studies over recent years have shown that NAFLD predicts the development of diabetes and vice versa (1) and that each condition serves as a progression factor for the other (1)(2)(3)(4)(5). Although this association is likely to be partly the result of a "common soil," it is also probable that diabetes interacts with NAFLD via specific pathogenic mechanisms (6). In this context, the future challenges for the researcher and clinician alike will include increasing awareness of the association between diabetes and NAFLD, understanding pathogenic factors linking these conditions, screening for and diagnosing NAFLD progression noninvasively and cost effectively in those at risk, and establishing effective interventions for NAFLD in diabetes to prevent both hepatic and systemic sequelae.…”

Section: Introductionmentioning

confidence: 99%

Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo

et al. 2012

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Recent data increasingly support a complex interplay between the metabolic condition diabetes mellitus and the pathologically defined nonalcoholic fatty liver disease (NAFLD). NAFLD predicts the development of type 2 diabetes and vice versa, and each condition may serve as a progression factor for the other. Although the association of diabetes and NAFLD is likely to be partly the result of a "common soil," it is also probable that diabetes interacts with NAFLD through specific pathogenic mechanisms. In particular, through interrelated metabolic pathways currently only partly understood, diabetes appears to accelerate the progression of NAFLD to nonalcoholic steatohepatitis, defined by the presence of necroinflammation, with varying degrees of liver fibrosis. In the research setting, obstacles that have made the identification of clinically significant NAFLD, and particularly nonalcoholic steatohepatitis, difficult are being addressed with the use of new imaging techniques combined with risk algorithms derived from peripheral blood profiling. These techniques are likely to be used in the diabetes population in the near future. This review examines the pathogenic links between NAFLD and diabetes by exploring the epidemiological evidence in humans and also through newer animal models. Emerging technology to help screen noninvasively for differing pathological forms of NAFLD and the potential role of preventive and therapeutic approaches for NAFLD in the setting of diabetes are also examined.

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Diabetes is a progression factor for hepatic fibrosis in a high fat fed mouse obesity model of non-alcoholic steatohepatitis

Cited by 92 publications

References 52 publications

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2

Fucoidan from sea cucumber Cucumaria frondosa exhibits anti-hyperglycemic effects in insulin resistant mice via activating the PI3K/PKB pathway and GLUT4

Diabetes and Nonalcoholic Fatty Liver Disease: A Pathogenic Duo

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