Diabetes mellitus and retinopathy

Gargiulo, Patrizia; Giusti, C; Pietrobono, Deborah; Torre, Daria La; Diacono, D; Tamburrano, G

doi:10.1016/j.dld.2003.11.016

Cited by 18 publications

(12 citation statements)

References 31 publications

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“…[7][8][9] Proliferative diabetic retinopathy (PDR), for example, is a frequently occurring complication of diabetes mellitus and characterized by an abnormal growth of blood vessels into the vitreous body. [10] Besides age-related macular degeneration (AMD), cataract, and glaucoma, PDR is one of the leading causes of blindness in industrialized nations. [11] Hydrogels are attractive materials for biomedical applications due to their versatility and excellent biocompatibility.…”

Section: Introductionmentioning

confidence: 99%

Poly(Ethylene Glycol) Based Hydrogels for Intraocular Applications

et al. 2007

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Hydrogels are attractive materials for biomedical applications due to their versatility and excellent biocompatibility. In this study, we report the preparation of poly(ethylene glycol) (PEG) based hydrogels for intraocular applications. We synthesized branched PEG‐succinimidyl propionates (10 kDa molecular weight) and different types of PEG‐amines (linear and branched, 2 and 10 kDa molecular weight). Transparent hydrogels were formed in situ upon chemical reaction of these macromers. The gels were characterized by oscillatory rheometry and NMR experiments. By varying the concentration of macromers, the functionality of the PEG‐amine, and the conditions during cross‐linking, gels with adequate gelation times of approx 5–10 min and gel strengths of approx 350–1500 Pa were obtained. The cross‐linked hydrogels showed no cytotoxic effects and may be used as vitreous substitutes or intraocular drug release systems.

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Section: Introductionmentioning

confidence: 99%

Poly(Ethylene Glycol) Based Hydrogels for Intraocular Applications

et al. 2007

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“…Recent studies have also indicated that miRNAs play important roles in many retinal diseases [13] , including retinal neovascularization [14] . Diabetic retinopathy (DR) is a retinopathy resulting from diabetes mellitus (DM), one of the major complications of DM, which can eventually lead to blindness [15,16] . DR can be divided into two types: background DR and proliferative DR. Proliferative DR refers to retinal neovascularization following ischemia whereas background DR changes occur before the onset of neovascularization [17,18] .…”

Section: Introductionmentioning

confidence: 99%

Altered MicroRNA Expression Profiles in Retinas with Diabetic Retinopathy

Wu¹,

Gao²,

Ren³

et al. 2011

Ophthalmic Res

104

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Rats with streptozotocin (STZ)-induced diabetes were studied in order to identify abnormal microRNA (miRNA) expression profiles in diabetic retinopathy (DR) and to ascertain miRNAs associated with DR. Histopathologically, we observed characteristic features of DR in rats at 10 weeks after STZ injection. Investigation of miRNA expression profiles in the retinas of control and diabetic rats using miRNA microarrays revealed that many miRNAs were abnormally expressed in DR. On the basis of their fold changes and probability values, a total of 37 miRNAs were selected for further validation by real-time PCR analysis. The results showed that 11 miRNAs were significantly upregulated and 6 miRNAs were notably downregulated in DR. Furthermore, these changes in retinal miRNA expression levels paralleled the course of DR. Levels of miR-182, miR-96, miR-183, miR-211, miR-204, and miR-124 were significantly increased during the progress of DR, whereas miR-10b, miR-10a, miR-219-2-3p, miR-144, miR-338, and miR-199a-3p were significantly decreased. Our data indicate that the aberrant miRNA expression profiles in DR are associated with the development of DR. Modulation of retinal miRNA expression levels may provide a potential therapeutic strategy for DRs.

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“…10 Many ophthalmic diseases, such as diabetic retinopathy and sensile vascular degeneration, also have an underlying microvascular component. 11,12 Several optical techniques are useful for direct imaging of microvascular morphology and function either clinically or in preclinical animal models. Intravascular fluorescence contrast agents can be used for imaging of microvessel morphology in some tissues with wide-field fluorescence imaging ͑e.g., retinal angiography with sodium fluorescein 13 ͒ or multiphoton microscopy using dyes or quantum dots.…”

Section: Introductionmentioning

confidence: 99%

Spectral imaging reveals microvessel physiology and function from anastomoses to thromboses

et al. 2010

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Abstract. Abnormal microvascular physiology and function is common in many diseases. Numerous pathologies include hypervascularity, aberrant angiogenesis, or abnormal vascular remodeling among the characteristic features of the disease, and quantitative imaging and measurement of microvessel function can be important to increase understanding of these diseases. Several optical techniques are useful for direct imaging of microvascular function. Spectral imaging is one such technique that can be used to assess microvascular oxygen transport function with high spatial and temporal resolution in microvessel networks through measurements of hemoglobin saturation. We highlight novel observation made with our intravital microscopy spectral imaging system employed with mouse dorsal skin-fold window chambers for imaging hemoglobin saturation in microvessel networks. Specifically, we image acute oxygenation fluctuations in a tumor microvessel network, the development of arteriovenous malformations in a mouse model of hereditary hemorrhagic telangiectasia, and the formation of spontaneous and induced microvascular thromboses and occlusions.

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Diabetes mellitus and retinopathy

Cited by 18 publications

References 31 publications

Poly(Ethylene Glycol) Based Hydrogels for Intraocular Applications

Poly(Ethylene Glycol) Based Hydrogels for Intraocular Applications

Altered MicroRNA Expression Profiles in Retinas with Diabetic Retinopathy

Spectral imaging reveals microvessel physiology and function from anastomoses to thromboses

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