Diabetes mellitus and risk of breast cancer: a large-scale, prospective, population-based study

Xiong, Fanxiu; Wang, Jingxuan; Nierenberg, Jovia L.; Blarigan, Erin L. Van; Kenfield, Stacey A.; Chan, June M.; Schmajuk, Gabriela; Huang, Chiung‐Yu; Graff, Rebecca E.

doi:10.1038/s41416-023-02345-4

Cited by 8 publications

(2 citation statements)

References 33 publications

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“…The impact of blood glucose levels on human health is often underestimated. Diabetes develops when the connection between the pancreas and insulin is disrupted and when insulin is not used [2,3]. The first mention of DM can be found in ancient Egypt.…”

Section: Introductionmentioning

confidence: 99%

Molecular Effect of Variants in Toll-like Receptor 4 Gene in Saudi Patients with Type 2 Diabetes Mellitus

Alkudmani,

Alshammary,

Ali Khan

2023

Cells

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Single-nucleotide polymorphisms (SNPs) in the Toll-like receptor 4 (TLR4) gene have been documented in type 2 diabetes mellitus (T2DM) and other diseases in the Saudi population. We investigated the relationship between rs11536889, rs4986790, and rs4986791 SNPs in the TLR4 gene and T2DM in the Saudi population; 105 patients with T2DM and 105 healthy controls were analyzed. The TLR4 gene was amplified through PCR, followed by restriction fragment length polymorphism analysis for rs4986791 and Sanger sequencing for rs11536889 and rs4986790 SNPs. The clinical and biochemical characteristics were associated with T2DM (p < 0.05). The rs11536889, rs4986790, and rs4986791 SNPs in control subjects followed the Hardy–Weinberg equilibrium (p > 0.05). Alleles were associated with rs11536889, rs4986791, heterozygous codominant, and dominant models (p < 0.05). However, the rs4986790 SNP was not associated with T2DM (p > 0.05). Logistic regression analysis showed that high-density lipoprotein cholesterol (HDLc) levels were associated with T2DM (p < 0.001). Analysis of variance showed that waist (p = 0.0005) and hip circumferences (p = 0.002) in rs4986790 and rs4986791 SNPs, in SBP (p = 0.001), DBP (p = 0.002), and HDLc levels (p = 0.003), were associated with T2DM subjects. T2DM was also associated with the haplotype (p < 0.001) but not with linkage disequilibrium. The gene–gene interaction was associated with the three SNPs studied in patients with T2DM according to the generalized multifactor dimensionality reduction model (p < 0.0001). Dendrogram and graphical depletion analysis revealed a moderate association in patients with T2DM. The results suggest that rs11536889 and rs4986790 SNPs are genotypically and allelically associated with T2DM in Saudi patients. Future functional studies are recommended to validate the genetic roles of these SNPs in the pathogenesis and progression of diseases.

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Section: Introductionmentioning

confidence: 99%

Molecular Effect of Variants in Toll-like Receptor 4 Gene in Saudi Patients with Type 2 Diabetes Mellitus

Alkudmani,

Alshammary,

Ali Khan

2023

Cells

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“…The number of patients with diabetes is increasing year by year, but diabetes will bring many adverse risks to patients [11]. According to a meta analysis study, diabetes will increase the risk of cancer [12,13]. By 2030, cancer may become the most common cause of death in diabetes [14].…”

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confidence: 99%

Exploring the impact of diabetes on the prognosis of gastric cancer patients based on the survival data of gastric cancer patients in NHANES database and the survival data of Chinese gastric cancer patients

Zhou,

Cheng,

Chen

et al. 2023

Preprint

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Objectives At present, the prognosis of gastric cancer patients is poor, and many factors affect their prognosis. This study mainly explored the relationship between diabetes and the prognosis of patients with gastric cancer. Methods Collect clinical data of gastric cancer patients from the NHANES database from 1999 to 2020 and the First Affiliated Hospital of Anhui Medical University from 2015 to 2017. Integrating survival time, survival status, and covariates affecting prognosis in gastric cancer patients. To explore the relationship between diabetes and prognosis of gastric cancer patients by univariate and multivariate cox regression analysis Results In the clinical data of gastric cancer patients in NHANES database, in the three models constructed, there were differences between the history of diabetes and the prognosis of gastric cancer patients (p < 0.05). In the clinical data of gastric cancer patients in the first affiliated hospital of anhui medical university, there were differences between diabetes and gastric cancer prognosis in univariate and multivariate cox regression analysis (p < 0.05). Conclusions By analyzing the clinical data of gastric cancer patients in NHANES database and the First Affiliated Hospital of Anhui Medical University, we found that diabetes is a risk prognostic factor for gastric cancer.

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Two-dimensional polymeric cobalt phthalocyanine synthesized by microwave irradiation and its use for continuous glucose monitoring

Jeon,

You,

et al. 2023

Korean J. Chem. Eng.

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Diabetes mellitus and risk of breast cancer: a large-scale, prospective, population-based study

Cited by 8 publications

References 33 publications

Molecular Effect of Variants in Toll-like Receptor 4 Gene in Saudi Patients with Type 2 Diabetes Mellitus

Molecular Effect of Variants in Toll-like Receptor 4 Gene in Saudi Patients with Type 2 Diabetes Mellitus

Exploring the impact of diabetes on the prognosis of gastric cancer patients based on the survival data of gastric cancer patients in NHANES database and the survival data of Chinese gastric cancer patients

Two-dimensional polymeric cobalt phthalocyanine synthesized by microwave irradiation and its use for continuous glucose monitoring

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