Diabetic Renal Injury Induced in Experimental Rats-Role of Curcuminoids as Probable Therapeutic Agent

Abstract

Abstract-Background: Renal injury may develop in uncontrolled diabetic manifestations, mostly attributed to increased oxidative stress and release of pro-inflammatory mediators and finally leading to diabetic complications. Methods: Curcumenoids which have anti-oxidant and anti-inflammatory properties were tested in alloxan-induced hyperglycemia in rats on oxidative stress, gene expression of tumor necrosis factor-α (TNF-α) and transforming growth factor-β1 (TGF-β1), in relation to microalbuminuria and renal function. Results: We found that the onset of microalbuminuria preceded the increase in serum glucose after alloxan administration. Gene expression of TNF-α and TGF-β1 showed a gradual increase after one and two weeks of alloxan administration as compared to the normal group. Curcumenoids administration decreased gene expression of TNF-α and TGF-β1 in kidneys, serum-glucose, fructosamine, urea, creatinine, C-reactive protein, malondialdehyde, urinary microalbumin and total protein. Histological examination of kidney tissues showed significant improvement in Curcumenoids-treated rats as compared to untreated diabetic rats. Conclusions: Curcumenoids modulated renal injury of alloxan-induced diabetic rats as revealed by observed biochemical data. This may refer to it as therapeutic candidate for treatment of diabetic renal injury and clinical trials are mostly requested.

Anti-Diabetic and Reno-Protective Effect of the Ethanolic Extract of Solanum Indicum in Alloxan-Induced Diabetic Rats

“…ESI and glibenclamide prevent the change in urine output, protein and creatinine. (13) Results of renoprotective activity are summarised in Table 2, Table 3, Table 4 respectively. Table 2: Effect of ESI on Urine Volume (mL/6 hrs.)…”