Diagnosis and Clinical Course of Ulcerative Gastroduodenal Lesion Associated With Ulcerative Colitis: Possible Relationship With Pouchitis

Abstract

In more than half of the post-proctocolectomy patients, UGDL was related to the occurrence of pouchitis. The existence of characteristic UGDL must be taken into account in the diagnosis and treatment of UC, and UGDL is possibly related to the occurrence of pouchitis.

Two Cases of Diffuse Duodenitis Associated with Ulcerative Colitis

“…UC-associated diffuse duodenitis is characterized by duodenal lesions that closely resemble UC lesions in the colon in both the endoscopic and pathological findings [1–3, 5]. UC-associated diffuse duodenitis is often seen in the bulb and/or the descending and/or the horizontal portion of the duodenum, and endoscopic findings show multiple erosions, aphthae (multiple white spots surrounded by a red halo), ulcers, and granular changes that are similar in appearance to colonic lesions of UC.…”

“…These reports described gastritis or diffuse duodenitis that resembled colonic lesions of UC in both the endoscopic and pathological findings. Recently, some case series and case-control studies reported that gastroduodenal involvement in UC may be more frequent than previously estimated [5–8]. The occurrence of gastrointestinal involvement in UC has been attracting attention because such lesions could potentially open a new window for studying the etiology and pathogenesis of UC.…”

Comparison of Small Bowel Lesions Using Capsule Endoscopy in Ulcerative Colitis and Crohn’s Disease: A Single-Center Retrospective Analysis

“…The presence of gastroduodenal lesions [5-10] and small bowel lesions [11-15] in UC has been reported in recent years, with an incidence of 4.7–7.6% [8, 9] for gastroduodenal lesions and 36–57% [13, 14] for small bowel lesions. Our study similarly found an incidence of 27.8% for small bowel lesions in UC, lending further support to the idea that such lesions are not uncommon in UC.…”

Ulcerative colitis with gastric and duodenal involvement

“…Gastroduodenal involvement is more frequent in young people (1,3), and is related with low doses of corticoids, recurrent pouchitis (7.4% of the cases) and more serious forms of presentation (active pancolitis, 6.2%) (1,2).…”