Diagnosis and Management of First Case of COVID-19 in Canada: Lessons Applied From SARS-CoV-1

Marchand-Sénécal, Xavier; Kozak, Rob; Mubareka, Samira; Salt, Natasha; Gubbay, Jonathan B.; Eshaghi, Alireza; Allen, Vanessa; Li, Yan; Bastien, Natalie; Gilmour, Matthew W.; Ozaldin, Omar; Leis, Jerome A

doi:10.1093/cid/ciaa227

Cited by 129 publications

(101 citation statements)

References 11 publications

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“…A case report describing the first case of Canada showed that the patient had symptoms of hemoptysis on days 2 through 6 along with fever and non-productive cough on presentation [24]. Lillie et al presented a case where symptom onset started with fever, which then progressed to sore throat and dry cough followed by diffuse myalgia.…”

Section: Clinical Signs/symptomsmentioning

confidence: 99%

COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective

et al. 2020

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Coronavirus disease 2019 caused infection in 168,000 cases worldwide in about 148 countries and killed more than 6,610 people around the world as of March 16, 2020, as per the World Health Organization (WHO). Compared to severe acute respiratory syndrome and Middle East respiratory syndrome, there is the rapid transmission, long incubation period, and disease containment is becoming extremely difficult. The main aim of this systematic review is to provide a comprehensive clinical summary of all the available data from high-quality research articles relevant to the epidemiology, demographics, trends in hospitalization and outcomes, clinical signs and symptoms, diagnostic methods and treatment methods of COVID-19, thus increasing awareness in health care providers. We also discussed various preventive measures to combat COVID-19 effectively. A systematic and protocol-driven approach is needed to contain this disease, which was declared as a global pandemic on March 11, 2020, by the WHO. Literature Search MethodsWe conducted a systematic search of published articles from PubMed, google scholar databases and in-press literature from google search engine through snowballing. There were two independent reviewers, each focusing on COVID-19, novel coronavirus (nCoV), SARS and MERS, and third independent reviewer to resolve any conflicting article of interest. We used the keywords as mentioned above and after stringent exclusion criteria, a total of 58 articles, including reports from the trusted newspapers and websites. Most of the articles were single case reports, multiple case studies and systematic reviews (11 retrospective studies, one meta-analysis, three systematic reviews, six case series, five case reports, five newspapers, 24 science research articles, and rest 3 reference's from official websites). EpidemiologyThe initial cases were strongly associated with the Huanan seafood market, in which exotic animals were sold for food [3]. According to Lu et al, the virus (termed SARS-CoV-2) shares 88% sequence identity to two coronaviruses found in bats, bat-

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Section: Clinical Signs/symptomsmentioning

confidence: 99%

COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective

et al. 2020

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“…1 Although there are numerous case series and commentaries regarding the natural course of the pandemic, there is a relative paucity of data specific to the ED context. [3][4][5][6][7] Given that the number of new COVID-19 cases is likely to wax and wane in response to dynamic public health policies, it remains imperative that ED clinicians have regular, real-time and locally relevant information to inform patient care.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and clinical features of emergency department patients with suspected COVID‐19: Initial results from the COVID‐19 Emergency Department Quality Improvement Project (COVED‐1)

O’Reilly

Mitchell

Rajiv

et al. 2020

Emerg Medicine Australasia

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“…When assessing patients with deteriorating conditions, it has been noted that CRP is significantly raised and albumin is low(31). While no clear guidelines exist on the evaluation of response to supportive treatment, a study by Cascella et al has suggested that laboratory evaluation of samples from patients should demonstrate viral clearance prior to discharging from observation in the form of two negative respiratory tract specimens taken at least 24 hours apart(66,67).…”

mentioning

confidence: 99%

Evidence based management guideline for the COVID-19 pandemic - Review article

Nicola

O’Neill

Sohrabi

et al. 2020

International Journal of Surgery

368

306

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COVID-19 has now been declared a pandemic. To date, COVID-19 has affected over 944,181 people worldwide, resulting in over 47,312 reported deaths. Numerous preventative strategies and non-pharmaceutical interventions have been employed to mitigate the spread of disease including careful infection control, the isolation of patients, and social distancing. Management is predominantly focused on the provision of supportive care, with oxygen therapy representing the major treatment intervention. Medical therapy involving corticosteroids and antivirals have also been encouraged as part of critical management schemes. However, there is at present no specific antiviral recommended for the treatment of COVID-19, and no vaccine is currently available. Despite the strategic implementation of these measures, the number of new reported cases continues to rise at a profoundly alarming rate. As new findings emerge, there is an urgent need for up-to-date management guidelines. In response to this call, we review what is currently known regarding the management of COVID-19, and offer an evidence-based review of current practice.

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Diagnosis and Management of First Case of COVID-19 in Canada: Lessons Applied From SARS-CoV-1

Cited by 129 publications

References 11 publications

COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective

COVID-19, Modern Pandemic: A Systematic Review From Front-Line Health Care Providers’ Perspective

Epidemiology and clinical features of emergency department patients with suspected COVID‐19: Initial results from the COVID‐19 Emergency Department Quality Improvement Project (COVED‐1)

Evidence based management guideline for the COVID-19 pandemic - Review article

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