Diagnosis of colonic amebiasis and coexisting signet-ring cell carcinoma in intestinal biopsy

Grosse, A

doi:10.3748/wjg.v22.i36.8234

Cited by 9 publications

(6 citation statements)

References 22 publications

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“…The upregulation of LAMC2 contributes to the prognosis and metastasis of ESCC [23]. Amebiasis was recently reported in a patient diagnosed with colonic amebiasis and signet-ring cell carcinoma of the ileocecal valve [24]. In the African community, it was reported that 4 patients developed esophageal cancer from the chronic tract, and there was a strong association between chronic infection with gastrointestinal schistosomiasis and amebiasis and the likelihood of developing tumors [18].…”

Section: Discussionmentioning

confidence: 99%

SPP1 and FN1 associated with progression and prognosis of esophageal cancer identified by integrated expression profiles analysis

Wang

Pang

et al. 2020

Med Sci Monit

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Background: Esophageal cancer is a malignant tumor with a complex pathogenesis and a poor 5-year survival rate, which encourages researchers to explore its molecular mechanisms deeper to improve the prognosis. Material/Methods: DEGs were from 4 Gene Expression Omnibus (GEO) databases (GSE92396, GSE20347, GSE23400, and GSE45168) including 87 esophageal tumor samples and 84 normal samples. We performed Gene Ontology (GO) analysis, Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Protein-Protein interaction (PPI) analysis, and GeneMANIA to identify the DEGs. Gene set enrichment analysis (GSEA) and Kaplan-Meier survival analyses were performed. Results: There was an overlapping subset consisting of 120 DEGs that was present in all esophageal tumor samples. The DEGs were enriched in extracellular matrix (ECM)-receptor interaction, as well as focal adhesion and transcriptional mis-regulation in cancer. The 2 most crucial regulatory pathways in esophageal cancer were the amebiasis pathway and the PI3K-Akt signaling pathway. Secreted phosphoprotein 1 (SPP1) and fibronectin 1 (FN1) were selected and verified in an independent cohort and samples using the TCGA and GTEx projects. Gene set enrichment analysis (GSEA) showed that proteasome and nucleotide excision repair were 2 most differentially enriched pathways in the SPP1 high-expression phenotype, and ECM-receptor interaction and focal adhesion in FN1 high-expression phenotype. Kaplan-Meier survival analysis showed that SPP1 and FN1 were significantly positively related to overall survival and had the potential to predict patient relapse. Conclusions: Our analysis is the first to show that SPP1 and FN1 might work as biological markers of progression and prognosis in esophageal carcinoma (ESCA).

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Section: Discussionmentioning

confidence: 99%

SPP1 and FN1 associated with progression and prognosis of esophageal cancer identified by integrated expression profiles analysis

Wang

Pang

et al. 2020

Med Sci Monit

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“…Colonic amoebiasis has been commonly demonstrated to mimic colon carcinoma (28–30). A rare case of colonic amoebiasis was identified to coexist with signet-ring cell carcinoma (31). All of these results support the hypothesis that PRKCA may contribute to the metastases of melanoma.…”

Section: Discussionmentioning

confidence: 99%

Identification of key candidate genes involved in melanoma metastasis

Chen

Shi

et al. 2019

Mol Med Report

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Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray dataset GSE8401 from the Gene Expression Omnibus database, which included 52 biopsy specimens from patients with melanoma metastasis and 31 biopsy specimens from patients with primary melanoma, differentially expressed genes (DEGs) were identified, subsequent to data preprocessing with the affy package, followed by Gene Ontology and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses. A protein-protein interaction (PPI) network was constructed. Mutated genes were analyzed with 80 mutated cases with melanoma from The Cancer Genome Atlas. The overall survival of key candidate DEGs, which were within a filtering of degree >30 criteria in the PPI network and involved three or more KEGG signaling pathways, and genes with a high mutation frequency were delineated. The expression analysis of key candidate DEGs, mutant genes and their associated genes were performed on UALCAN. Of the 1,187 DEGs obtained, 505 were upregulated and 682 were downregulated. ‘Extracellular exosome’ processes, the ‘amoebiasis’ pathway, the ‘ECM-receptor interaction’ pathway and the ‘focal adhesion’ signaling pathway were significantly enriched and identified as important processes or signaling pathways. The overall survival analysis of phosphoinositide-3-kinase regulator subunit 3 ( PIK3R3 ), centromere protein M ( CENPM ), aurora kinase A ( AURKA ), laminin subunit α 1 ( LAMA1 ), proliferating cell nuclear antigen ( PCNA ), adenylate cyclase 1 ( ADCY1 ), BUB1 mitotic checkpoint serine/threonine kinase ( BUB1 ), NDC80 kinetochore complex component ( NDC80 ) and protein kinase C α ( PRKCA ) in DEGs was statistically significant. Mutation gene analysis identified that BRCA1-associated protein 1 ( BAP1 ) had a higher mutation frequency and survival analysis, and its associated genes in the BAP1 -associated PPI network, including ASXL transcriptional regulator 1 ( ASXL1 ), proteasome 26S subunit, non-ATPase 3 ( PSMD3 ), proteasome 26S subunit, non ATPase 11 ( PSMD11 ) and ubiquitin C ( UBC ), were statistically significantly associated with the overall survival of patients with melanoma. The expression levels of PRKCA, BUB1, BAP1 and ASXL1 were significantly different between primary melanoma and metastatic melanoma. Based on the present study, ‘extracellular exosome’ processes, ‘amoebiasis’ pathways, ‘ECM-receptor interaction’ pathways and ‘focal adhesion’ signaling pathways may be important in the formation of metastases from melanoma. Th...

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“…The diagnosis of FAC, in these cases, was determined postoperatively based on the pathological examination of extracted specimens or a postoperative endoscopic biopsy (Table 1 ). The clinical symptoms of amoebic colitis can range from mild diarrhea, abdominal cramps, and right-lower quadrant tenderness, to severe abdominal cramps, fever, and mucoid or bloody diarrhea [ 30 ]. The differential diagnosis of a diarrheal illness with bloody stool also includes a probable infection by Shigella , Salmonella , Campylobacter species and enteroinvasive and enterohemorrhagic Escherichia coli .…”

Section: Discussionmentioning

confidence: 99%

Lethal multiple colon necrosis and perforation due to fulminant amoebic colitis: a surgical case report and literature review

et al. 2021

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Background Amoebiasis caused by the protozoan species Entamoeba histolytica rarely develops into fulminant amoebic colitis (FAC), but when it does, it shows an aggressive clinical course including colonic perforation, necrotizing colitis, and high mortality. Surgical treatment for FAC patients should be carried out urgently. However, even after surgery, the mortality rate can be 40–50%. Although FAC is one of the most unfavorable surgical diseases with a poor prognosis, there are a few reports on the perioperative diagnosis and management of FAC based on autopsy findings. We herein report the surgical case of a 64-year-old man who developed multiple colon necrosis and perforation due to FAC. A detailed autopsy revealed FAC as the cause of death. Additionally, we reviewed the existing literature on FAC patients who underwent surgery and followed their perioperative diagnosis and management. Case presentation A 64-year-old man presented with anorexia, diarrhea, and altered consciousness on arrival to our hospital. Computed tomography revealed a large mass in the upper right lobe of his lung, and the patient was admitted for close investigation. Bloody diarrhea, lower abdominal pain, and hypotension were observed soon after admission. Urgent abdominal contrast-enhanced computed tomography scan revealed extensive intestinal ischemia, intestinal pneumatosis, and free intra-abdominal gas. The preoperative diagnosis was bowel necrosis and perforation with intussusception of the small intestinal tumor. Emergency subtotal colectomy and enterectomy were performed soon after the contrast-enhanced computed tomography. He was taken to an intensive care unit after surgery. However, he could not recover from sepsis and died with disseminated intravascular coagulation and multiple organ failure on the 10th-day post-surgery. A histopathological examination of the resected colon showed transmural necrosis and massive amoebae invasion. He was diagnosed with FAC. An autopsy revealed that he had developed pulmonary large cell carcinoma with small intestinal metastasis. The death was caused by intestinal ischemia, necrosis and the perforation of the residual bowel caused by amoebae invasion. Conclusions Since FAC is a lethal disease with a high mortality rate and antibiotic therapies except metronidazole are ineffective, preoperative serological testing and perioperative metronidazole therapy in FAC patients can dramatically improve their survival rates.

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Diagnosis of colonic amebiasis and coexisting signet-ring cell carcinoma in intestinal biopsy

Cited by 9 publications

References 22 publications

SPP1 and FN1 associated with progression and prognosis of esophageal cancer identified by integrated expression profiles analysis

SPP1 and FN1 associated with progression and prognosis of esophageal cancer identified by integrated expression profiles analysis

Identification of key candidate genes involved in melanoma metastasis

Lethal multiple colon necrosis and perforation due to fulminant amoebic colitis: a surgical case report and literature review

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