Diagnosis of Leishmania infection in a nonendemic area of South America

Abstract

American tegumentary leishmaniasis is the generic name for a variety of cutaneous and mucocutaneous presentations of parasitosis caused by several species of the genus Leishmania. This is a widespread infection in the American continent, from the South of the United States to the North of Argentina. We herein describe the management of a patient with American tegumentary leishmaniasis in Mendoza, Argentina, a nonendemic area of South America, whose diagnosis and treatment were significantly delayed, because the patient did not report a recent history of travel to any known endemic areas. This case stresses the need for training health-care professionals in the diagnosis and treatment of not only endemic parasitosis within their work zones but also nonendemic parasitosis.

Windows into Canine Leishmaniasis: From Veterinary Diagnosis to Promising<em> In Vitro </em>Models to Target Parasite-Secreted Lipid Bound Vesicles

“…Therefore, new protocols are needed to achieve a better efficacy in the prevention and clinical treatment, and they can include the relation of lipids released from parasites [1]. Different types of laboratory tests are available to diagnose parasitic infections, like conventional methods considered as gold standards and serological [48][49][50]. Several molecular diagnostic tools to detect parasites and new strains have been developed in the last decades [48][49][50].…”

“…Different types of laboratory tests are available to diagnose parasitic infections, like conventional methods considered as gold standards and serological [48][49][50]. Several molecular diagnostic tools to detect parasites and new strains have been developed in the last decades [48][49][50]. Accurate diagnosis of zoonotic infections collaborates with the work of medical scientists, policy makers and public health officials planning to prevent the dissemination of these diseases and establishing a world-wide network of surveillance for the coinfection of parasitic infections [49,50].…”

Network-Based Approaches Reveal Potential Therapeutic Targets for Host-Directed Antileishmanial Therapy Driving Drug Repurposing

“…The use of minocycline in the treatment of malaria has shown a decrease in T-cell-mediated brain inflammation and a reduction in gene expression independent of the antiparasitic property ( 73 ). Nonetheless, a more recent study reported that a patient diagnosed with leishmaniasis was treated with minocycline ( 74 ). However, the treatment was stopped shortly after and nonconclusive results were obtained.…”

Leishmaniasis in the Argentine Republic: Temporal and geographical distribution from 2013 to 2017

“…They are factors that trigger changes in the dynamics of the vector's dispersal, contributing to new establishments of the disease. For these reasons, provinces outside the endemic area of leishmaniasis have reported confirmed cases [36].…”